This phase 2 clinical noninferiority trial compared 4 doses of postoperative osocimab, a monoclonal antibody against factor XI, vs enoxaparin and apixiban on venous thromboembolism incidence among patients undergoing knee replacement.
This randomized trial compares the effect of a counseling intervention to promote consumption of 7 or more daily vegetable servings vs an educational control on time to PSA- and biopsy-defined cancer progression in men with early-stage prostate cancer.
This cohort study compares functional outcomes, including sexual and bowel function and urinary incontinence, associated with active surveillance, surgery, or radiation therapy 5 years after treatment.
This cohort study uses data from state health care databases to determine the incidence and timing of infectious complications following cochlear implant surgery among patients in 5 US states between 2006 and 2016.
This study uses electronic health record (EHR) data to evaluate differences in central line–associated bloodstream infection (CLABSI) rates by how central line days are counted: once a day at a fixed time for all patients; a sampling-based approximation; or a validated electronic count.
This study uses publicly available and FDA data to describe changes in drug testing laws and standards, the use of new FDA approval programs and standards, changes in the role and authority of the FDA, and changes in the number of drugs the FDA has approved from 1983 to 2018.
This Viewpoint discusses the reality that most decisions about treatment for incapacitated patients involve surrogate assessments of patients’ past values at their baseline health, and it proposes that more ethical and informed decision-making would help surrogates consider the degree to which their loved one might be able to adapt to and value a future health state at what is a higher level of disability.
This Viewpoint discusses 2 forces that can lead to the decline in competency in medicine over time, deterioration in ability with age and decrease in opportunities for maintenance and self-improvement, includes considerations that may be helpful to addressing competency decline.
In this narrative medicine essay, a resident physician shares the story of a young Haitian woman with cancer whose survival was threatened with deportation for having missed her residency application deadline and of his role in advocating for her care with US citizenship and immigration services.
This JAMA Performance Improvement article reports the methods and outcomes of a cognitive screening program implemented at a US hospital to assess medical staff aged 70 years or older for clinical competency every 2 years as a requirement for reappointment.
This JAMA Insights Clinical Update reviews current practice for managing mild traumatic brain injury, which includes monitoring symptom resolution, counseling on return to activity, and timely specialty referral.
This Medical News article discusses a recent study of federal and state legislation restricting high-capacity ammunition-feeding devices.
This JAMA Patient Page describes the causes, symptoms, diagnosis, and treatment of periorbital and orbital cellulitis.