This study used pooled cohort data to estimate the association between CT-assessed dysanapsis—a mismatch between airway tree caliber and lung size—and incident COPD in adults aged 60 years and older.
This cohort study uses Women’s Health Study data to compare the association of migraine with aura vs other major vascular risk factors (diabetes, hypertension, dyslipidemia, smoking, BMI, CVD family history) with incidence of cardiovascular disease.
This meta-analysis uses individual participant data from diagnostic accuracy studies to estimate the accuracy of the Patient Health Questionnaire–2 (PHQ-2) alone and combined with the PHQ-9 for detecting major depression.
This population epidemiology study characterizes trends in polymerase chain reaction (PCR) test positivity for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Washington State and the Seattle area between March 1 and April 16, 2020, before and after statewide physical distancing guidelines and stay-at-home orders.
This case series describes the proportion of awake, nonintubated inpatients with COVID-19 and hypoxemic respiratory failure requiring oxygen supplementation whose Pao2 increased ≥20% with prone positioning, and their respiratory status after resuming supine positioning.
This study measured respiratory parameters of 15 non-ICU patients before, during, and after receiving noninvasive ventilation in the prone position.
This cohort study compares rates of coronavirus PCR test positivity among Israelis with symptoms suspicious for COVID-19 who did and did not receive BCG vaccination as part of routine childhood immunization in the early 1980s.
This study uses 3D body scanner measurements of US Air Force recruits to compare ideal body proportions represented by Leonardo da Vinci’s Vitruvian Man with contemporary body proportions in young adult men and women.
This 2020 US Preventive Services Task Force Recommendation Statement recommends screening for unhealthy drug use in adults 18 years or older when services for diagnosis, treatment, and care can be offered or referred (B recommendation) and concludes that evidence is insufficient to assess the balance of benefits and harms of screening for unhealthy drug use in adolescents (I statement).
This systematic review to support the 2020 US Preventive Services Task Force Recommendation Statement on screening for unhealthy drug use including nonmedical use of prescription drugs in adolescents and adults summarizes published evidence on the benefits and harms of primary care–based screening.
This Viewpoint explains the ethical basis for implementing immunity-based licensing—certification of coronavirus immunity as a basis for permitting public activities—and anticipates challenges to effective implementing such a system, and potential solutions.
This Viewpoint explains the ethics of implementing licensing or certification of coronavirus immunity as basis for permitting public activities, anticipates challenges to effectively implementing such a system, and proposes potential policy solutions.
This Viewpoint describes what is currently known about the immune response to coronavirus disease 2019 (COVID-19), highlights important gaps in knowledge, and identifies opportunities for future research.
This Viewpoint discusses the need for population COVID-19 PCR and antibody surveys to better understand where communities are on the continuum of COVID-19 incidence and prevalence, to determine the effectiveness of mitigation strategies, and to plan for future mitigation strategies and development of vaccines and therapeutics.
This Viewpoint discusses the 2 most common categories of testing to diagnose SARS-CoV-2—real-time PCR to identify viral RNA and serological diagnosis of IgG and IgM antibodies to assess immune response—and estimates time intervals for test positivity by specimen source to help clinicians interpret results relative to symptom onset.
This Viewpoint discusses the prospect that face shields might be more effective than face masks at reducing community SARS-CoV-2 transmission and calls for rapid adoption of face shield-wearing by the public as an infection control strategy.
This Viewpoint proposes that universal respiratory precautions in the operating room—use of respirators with face masks and eye protection—could protect staff from possible coronavirus disease 2019 (COVID-19) infection and facilitate resumption of elective surgeries canceled during the first wave of the pandemic.
This Viewpoint discusses considerations that might lead physicians to change their practice based on RCTs reporting non–statistically significant differences in primary outcomes, including trial methodology, totality of evidence, cost, invasiveness, and labor-intensiveness of the interventions being compared.
This Viewpoint discusses the clinical implications of the US Centers for Disease Control and Prevention’s (CDC’s) 2020 recommendation to screen all adults for hepatitis C virus (HCV) infection at least once and pregnant women during each pregnancy, including the need to offer substance use disorder referral and testing protocols for diagnosing perinatal HCV infection in newborns.
In this narrative medicine essay, a medical student describes 3 patient deaths whose care she was involved in and expresses her hopes that what she learned will ground her professional course in compassion and patient care.
This JAMA Insights Clinical Update discusses the pathophysiology of SARS-CoV-2–related respiratory failure, distinguishing unique L and H phenotypes and their implications for ventilator strategies and settings.
This JAMA Clinical Guidelines Synopsis summarizes the American Gastroenterological Association Institute’s 2018 guideline on initial management of acute pancreatitis.
This Medical News feature describes an international effort to compile data about ventilated patients with COVID-19.
This Medical News article is an interview with the University of New Mexico’s Eileen Barrett, MD, MPH, about the pandemic’s mental toll on health care workers—and how they and their employers can safeguard their emotional well-being.
This Arts and Medicine feature draws lessons from Sophocles’ classic tragedies Oedipus Rex and Oedipus at Colonus about the limits of medicine and the importance of community in the midst of the coronavirus (COVID-19) pandemic.
This JAMA Patient Page summarizes the US Preventive Services Task Force’s 2020 recommendations on screening for unhealthy drug use in adults and adolescents.