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February 2020 - July 1883




February 4, 2020, Vol 323, No. 5, Pages 399-486

In This Issue of JAMA

Audio Highlights

Abstract Full Text
free access online only has audio
JAMA. 2020;323(5):e200007. doi:10.1001/jama.2020.0007
Original Investigation

Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinical Trials

Abstract Full Text
JAMA. 2020;323(5):432-443. doi:10.1001/jama.2019.22450

Because intravenous (IV) iron can induce hypophosphatemia, the 2 clinical trials in this report directly compare the effects of 2 IV iron formulations, iron isomaltoside (now known as ferric derisomaltose) and ferric carboxymaltose, on phosphate levels in patients with iron-deficiency anemia unresponsive to oral iron.

Association Between Neurological Disorders and Death by Suicide in Denmark

Abstract Full Text
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JAMA. 2020;323(5):444-454. doi:10.1001/jama.2019.21834

This population epidemiology study uses Danish registry data to examine associations between neurological disorders and higher suicide rates from 1980 through 2016.

Association of Home Noninvasive Positive Pressure Ventilation With Clinical Outcomes in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA. 2020;323(5):455-465. doi:10.1001/jama.2019.22343

This meta-analysis of trials and observational studies evaluates the association of the use of home noninvasive positive pressure ventilation (NIPPV) via home mechanical ventilator (HMV) and bilevel positive airway pressure (BPAP) devices with clinical outcomes and adverse events in patients with chronic obstructive pulmonary disease (COPD) and hypercapnia.

Preliminary Communication

Caring for the Critically Ill Patient

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;323(5):423-431. doi:10.1001/jama.2019.22176

This randomized clinical trial compares the effects of treatment with intravenous vitamin C, hydrocortisone, and thiamine compared with intravenous hydrocortisone alone on duration of time alive and free of vasopressor use over 7 days in patients with septic shock.

Research Letter

Self-reported Marijuana Use in Electronic Cigarettes Among US Youth, 2017 to 2018

Abstract Full Text
JAMA. 2020;323(5):473-474. doi:10.1001/jama.2019.19571

This population epidemiology study uses data from the National Youth Tobacco Survey to assess trends in self-reported use of marijuana in electronic cigarettes among US middle school and high school students from 2017 to 2018.

Trends in Reported Marijuana Vaping Among US Adolescents, 2017-2019

Abstract Full Text
JAMA. 2020;323(5):475-476. doi:10.1001/jama.2019.20185

This national survey study uses Monitoring the Future data to characterize trends in the prevalence of marijuana vaping in 2017, 2018, and 2019 among 8th, 10th, and 12th graders.


Billing Quality Is Medical Quality

Abstract Full Text
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JAMA. 2020;323(5):409-410. doi:10.1001/jama.2019.19648

This Viewpoint discusses the adverse effects on patients of low billing quality (such as extremes in billing practices, pricing, and collection tactics), and proposes a 5-item rating system benchmarking billing quality to reduce financial harms and barriers to care, and improve health care quality and patient outcomes.

Evaluating the Potential Role of Social Media in Preventive Health Care

Abstract Full Text
JAMA. 2020;323(5):411-412. doi:10.1001/jama.2019.21084

In this Viewpoint, Raina Merchant uses the 2019 launch of Facebook’s Preventive Health tool, which makes preventive health recommendations based on user age and sex, to discuss the role of social media in influencing health behaviors, reaching vulnerable populations, and advancing public health.

Scientific Discovery and the Future of Medicine

Toward a Speech Neuroprosthesis

Abstract Full Text
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JAMA. 2020;323(5):413-414. doi:10.1001/jama.2019.19813

This Viewpoint describes principles underlying early brain-computer interfaces (BCIs) designed to read electrical brain signals, analyze how brain activity patterns contribute to vocal tract movements, and reproduce the sound patterns as speech toward the goal of restoring paralyzed individuals’ natural rate of communication and quality of life.

A Prescription for Longevity in the 21st Century: Renewing Purpose, Building and Sustaining Social Engagement, and Embracing a Positive Lifestyle

Abstract Full Text
JAMA. 2020;323(5):415-416. doi:10.1001/jama.2019.21087

This Viewpoint considers how physicians can help patients align health span with life span given trends toward increased longevity and emphasizes the importance of a sense of purpose, social engagement, and lifestyle choices to improve outcomes of morbidity, mortality, and quality of life.

A Piece of My Mind

The Power of a Healing Lie

Abstract Full Text
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JAMA. 2020;323(5):417-418. doi:10.1001/jama.2020.0001

In this narrative medicine essay, an Asian American hospital chaplain reviews the film The Farewell, which tells the story of a Chinese family taking elaborate measures to hide a cancer diagnosis from the family matriarch, and compares it to her own professional and personal experience.


Lack of Benefit of High-Dose Vitamin C, Thiamine, and Hydrocortisone Combination for Patients With Sepsis

Abstract Full Text
JAMA. 2020;323(5):419-420. doi:10.1001/jama.2019.22438

Home Noninvasive Ventilation for Patients With Chronic Obstructive Pulmonary Disease and Chronic Respiratory Failure

Abstract Full Text
JAMA. 2020;323(5):421-422. doi:10.1001/jama.2019.22484
JAMA Guide to Statistics and Methods

Using Propensity Score Methods to Create Target Populations in Observational Clinical Research

Abstract Full Text
JAMA. 2020;323(5):466-467. doi:10.1001/jama.2019.21558

This JAMA Guide to Statistics and Methods reviews how propensity score methods can be used with observational data to mimic comparison populations in a randomized trial and account for differences that might lead to biased conclusions.

JAMA Clinical Guidelines Synopsis

Human Papillomavirus Vaccination for Adults: Updated Recommendations of the Advisory Committee on Immunization Practices (ACIP)

Abstract Full Text
JAMA. 2020;323(5):468-469. doi:10.1001/jama.2019.18411

This JAMA Clinical Guidelines Synopsis summarizes the Advisory Committee on Immunization Practices’ 2019 updated recommendations for human papillomavirus vaccination for adults.

From The Medical Letter on Drugs and Therapeutics

Drugs for Some Common Eye Disorders

Abstract Full Text
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JAMA. 2020;323(5):470-471. doi:10.1001/jama.2019.20663

This Medical Letter review summarizes drugs available for the treatment of bacterial conjunctivitis and dry eye disease, including detail on formulations, dosage, and cost.

Medical News & Perspectives

Backlash Over Meat Dietary Recommendations Raises Questions About Corporate Ties to Nutrition Scientists

Abstract Full Text
JAMA. 2020;323(5):401-404. doi:10.1001/jama.2019.21441

This Medical News story examines the outcry over a recently published guideline that found insufficient evidence to recommend eating less red meat.

News From the Food and Drug Administration

Another Targeted Therapy for ERBB2-Positive Breast Cancer

Abstract Full Text
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JAMA. 2020;323(5):408. doi:10.1001/jama.2020.0222

New Migraine Drug Gains Approval

Abstract Full Text
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JAMA. 2020;323(5):408. doi:10.1001/jama.2020.0081

FDA’s New Effort to Improve Compounded Drug Quality

Abstract Full Text
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JAMA. 2020;323(5):408. doi:10.1001/jama.2020.0223
The JAMA Forum

Food Insecurity and a Threatened Safety Net

Abstract Full Text
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JAMA. 2020;323(5):406-407. doi:10.1001/jama.2019.22150
Bench to Bedside

DNA Prime Editing: A New CRISPR-Based Method to Correct Most Disease-Causing Mutations

Abstract Full Text
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JAMA. 2020;323(5):405-406. doi:10.1001/jama.2019.21827
Poetry and Medicine

To Make a Living

Abstract Full Text
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JAMA. 2020;323(5):481. doi:10.1001/jama.2019.21423
JAMA Revisited

Life, Death—and Bacteria

Abstract Full Text
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JAMA. 2020;323(5):482. doi:10.1001/jama.2019.13290
JAMA Patient Page

Causes of Memory Loss in Elderly Persons

Abstract Full Text
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JAMA. 2020;323(5):486. doi:10.1001/jama.2019.17421

This JAMA Patient Page describes different possible causes of memory loss, including neurodegenerative dementias and other conditions that may be reversible or permanent.

Comment & Response

HIPAA in the Era of Data Sharing

Abstract Full Text
JAMA. 2020;323(5):476-477. doi:10.1001/jama.2019.19645

HIPAA in the Era of Data Sharing—Reply

Abstract Full Text
JAMA. 2020;323(5):477. doi:10.1001/jama.2019.19655

Herd Protection Against Oral HPV Infection

Abstract Full Text
JAMA. 2020;323(5):477-478. doi:10.1001/jama.2019.19724

Herd Protection Against Oral HPV Infection—Reply

Abstract Full Text
JAMA. 2020;323(5):478. doi:10.1001/jama.2019.19727

Measuring Clinical Importance in a Trial of Interventions for Mixed Urinary Incontinence

Abstract Full Text
JAMA. 2020;323(5):479. doi:10.1001/jama.2019.19730

Measuring Clinical Importance in a Trial of Interventions for Mixed Urinary Incontinence—Reply

Abstract Full Text
JAMA. 2020;323(5):479. doi:10.1001/jama.2019.19733

Incorrect Data and Omitted Explanation for a Calculation

Abstract Full Text
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JAMA. 2020;323(5):480. doi:10.1001/jama.2019.20931

Incorrect Patient Numbers Reported in Tables

Abstract Full Text
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JAMA. 2020;323(5):480. doi:10.1001/jama.2019.21742

Incorrect Bars in Graph Showing Gene Mutations

Abstract Full Text
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JAMA. 2020;323(5):480. doi:10.1001/jama.2019.21753
JAMA Masthead


Abstract Full Text
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JAMA. 2020;323(5):399-400. doi:10.1001/jama.2019.13283