This randomized clinical trial compares the effects of incisional negative pressure wound therapy vs standard wound dressing on deep surgical site infection (SSI) at 30 days among patients undergoing surgery for major trauma–related lower limb fractures.
This randomized trial compares the effect of combining standard antibiotic therapy (intravenous vancomycin or daptomycin) with an antistaphylococcal β-lactam (intravenous flucloxacillin, cloxacillin, or cefazolin) vs standard therapy alone on a composite outcome of mortality, bacteremia, relapse, or treatment failure in adults with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia.
This study uses claims data from a large US health insurer to describe the proportion of times patients who had undergone elective surgery at in-network facilities with in-network primary surgeons received out-of-network bills between 2012 and 2017.
This study uses a random survey of US hospice agencies to estimate rates of confirmed and suspected cases of medication diversion away from patients in hospice and association of diversion rates with agency characteristics and state opioid death rates.
This study uses National Surveys on Drug Use and Health data to characterize trends in heroin use, heroin use disorder, and heroin injection overall and by age, race, and geographic region.
This Viewpoint proposes an early result match program for applicants to postgraduate training programs, much like early decision programs at undergraduate colleges, as a means to address the rise in number of residency applications and to ensure better fit between trainees and programs.
This Viewpoint uses the framework of exploitation, an unequal sharing of benefits and harms between parties in an agreement, to highlight the ethical risks inherent in data-sharing partnerships between health systems and for-profit technology companies and to explore potential strategies for addressing those risks.
This Viewpoint proposes principles of security, transparency, and privacy to guide data-sharing agreements between clinical organizations and digital technology companies as both seek electronic health record (EHR) data to grow their business and improve health care delivery and outcomes.
This Viewpoint summarizes the 2019 AI in Healthcare report from the National Academy of Medicine (NAM), which reviews best practices for AI development, adoption, and maintenance and urges prioritization of equity, inclusion, and human rights in AI health system implementation.
In this narrative medicine essay, a general pediatrics resident recalls the doubt and fear surrounding her high school diagnosis of ideopathic bone marrow suppression syndrome, her slow journey to recovery, and her how her family and physicians who cared for her nurtured her ambition to become a pediatric oncologist.
This narrative review summarizes the clinical manifestations of Parkinson disease, proposes an algorithm for diagnosing and classifying subtypes of the disease, and discusses pharmacologic and nonpharmacologic approaches for managing its most troublesome signs and symptoms including tremor, dyskinesias, gait disturbance, and cognitive impairment.
This JAMA Insights Clinical Update reviews recent evidence favoring use of inhaled corticosteroids (ICS)in all patients with asthma, regardless of frequency, and summarizes the SMART (single maintenance and reliever therapy) treatment approach, which uses an inhaler combining ICS and formoterol for control and relief of symptoms, and differences between SMART and symptom-driven therapy.
This JAMA Insights Clinical Update reviews management of asthma exacerbations, including the use of inhaled corticosteroids (ICS), azithromycin, magnesium sulfate, and nebulized bronchodilators vs metered-dose inhalers (MDIs), and discusses the potential future role of benralizumab and other biological therapies.
This Medical News article discusses new international recommendations for female testosterone therapy.
This JAMA Patient Page describes use of preparations of the cannabis plant to treat medical conditions, the strength of evidence supporting such use, and the risks involved.
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