This randomized trial compares the effects of intravenous interferon β-1a vs placebo on 28-day mortality and on ventilator-free days in patients with moderate to severe acute respiratory distress syndrome (ARDS).
This study uses registry data to compare risk of in-hospital mortality and major bleeding among patients with acute coronary syndrome and cardiogenic shock managed with an intravascular microaxial left ventricular assist device (LVAD) vs intra-aortic balloon pulsation (IABP).
This randomized trial compares the accuracy of screening with abbreviated breast magnetic resonance imaging (MRI) vs digital breast tomosynthesis (DBT) on invasive breast cancer detection rates in women with dense breasts.
This study uses SECURE-PCI trial data to compare the effects of periprocedural loading doses of atorvastatin vs placebo on major adverse cardiac events (MACE) 12 months after randomization in patients with acute coronary syndrome (ACS) and planned invasive management.
This 2020 Recommendation Statement from the US Preventive Services Task Force concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for cognitive impairment in adults 65 years or older (I statement).
This systematic review to support the 2020 US Preventive Services Task Force Recommendation Statement on screening for cognitive impairment in older adults summarizes published evidence on the benefits and harms of cognitive impairment screening and treatment in adults 65 years or older.
This Viewpoint discusses the challenge prior medication authorization procedures presents for patients, physicians, and practices, and it proposes principles to guide “prior auth” reform, including focusing the procedures on the initial intended purpose of managing use of high-cost drugs that have equivalent lower-cost alternatives, protecting the continuity of medication for patients, and being transparent, efficient, and fair in their requirements.
In this Viewpoint, Berwick and colleagues review the evolution of prior authorization (“prior auth”) into a process where insurers deny previously approved coverage, patients receive surprise bills, and clinicians spend time appealing charges, and propose the introduction of legal provisions that make authorization decisions binding and absolve patients, clinicians, and organization of financial responsibility for previously approved services.
In this Viewpoint Anthony Fauci and colleagues review the emergence of pathogenic human coronaviruses (SARS-Cov and MERS-CoV) as background for discussing a rapidly spreading novel coronavirus (2019-nCoV) identified in 2019 in China and the public health strategies necessary to contain the threat.
In this Viewpoint, Gostin and colleagues review the emerging novel coronavirus (2019-nCoV) outbreak, discuss the public health benefits and risks of the Chinese government’s large city quarantines, and call for WHO leadership to coordinate a global coordinated response that could contain this and prevent similar future outbreaks.
In this narrative medicine essay, an internist traces the vicissitudes of hope and despair during his wife’s long battle with breast cancer and highlights how encouraging words from nontreating physicians serve as branches of hope that communicate an unpredictable prognosis.
This Medical News feature discusses “street medicine,” the practice of caring for unsheltered homeless individuals.
This JAMA Patient Page describes recent US Preventive Services Task Force recommendations on screening for cognitive impairments in older adults.