This open-label randomized trial compares the effect of remdesivir (5 or 10 days) vs standard care on clinical status 11 days after treatment initiation among patients with confirmed SARS-CoV-2 infection hospitalized with moderate pneumonia (room air oxygen saturation >94%).
This study of adult patients with out-of-hospital cardiac arrest compares rates of survival to hospital discharge for those receiving EMS transport vs continued on-scene resuscitation .
This cohort study evaluates IgG antibody concentrations in preterm infants after administration of combination diphtheria–tetanus toxoids–acellular pertussis–inactivated poliomyelitis–Haemophilus influenza type b–and hepatitis B (DTaP-IPV-Hib-HepB) and pneumococcal conjugate vaccines.
This study describes the point prevalence of polymerase chain reaction tests positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among residents of a sample of Connecticut nursing homes in the first half of May 2020.
This study evaluates COVID-19 case rates between high- and low-performing nursing homes based on CMS quality measures.
This survey study assesses US pediatrician practices and office policies in response to parents who either refuse primary vaccinations or request to spread out individual vaccines in the primary series.
This Special Communication summarizes consensus recommendations from the World Brain Death project, an international collaborative created to establish minimum standards for diagnosing brain death/death by neurologic criteria (BD/DNC) in children and adults across a broad range of settings and clinical circumstances.
In this Viewpoint, the NIH director and acting chief of staff discuss how Henrietta Lacks’ cervical cancer cells (HeLa) were used without her consent to create an immortal cell line used widely in modern medical research, and argue for development of policies to prevent unauthorized use of biological specimens to prevent the same thing from happening again.
In this Viewpoint, CDC scientists discuss the public health urgency of increasing influenza vaccination uptake early in the 2020-2021 season to ameliorate the threat to patients and hospitals of overlapping outbreaks, and urges clinicians to strongly recommend the vaccine and administer it to patients whenever and wherever possible.
This Viewpoint discusses the importance of studying coronavirus disease 2019 (COVID-19) vaccine candidates in prisoners, and proposes a framework for considering how to include them safely, ethically, and without coercion in future phase 3 vaccine trials.
This Viewpoint discusses the ways medical schools adapted to the coronavirus disease 2019 (COVID-19) pandemic, allowing students to be part of the public health response, adapting curricula to educational opportunities, and modernizing means of instruction without losing time or compromising standards.
This Viewpoint challenges US hospital claims that government funding to train physicians is necessary to offset costs, maintain physician supply, and keep costs low for other payers, and proposes reforms to use the monies to target known problems, such as geographic disparities in physician workforce and inadequate primary care and public health physician supply.
This Viewpoint discusses ways that evidence-based laws can address health disparities and halt the documented reduction of life expectancy across socioeconomic groups in the US, including through regulation of hazardous products, behavioral economic incentives, wage increases, and provision of public benefits.
In this narrative medicine essay, a psychologist recounts how she found her voice through writing and in patient care advocacy and research and how she helped her son, who has Schwartz-Jampel syndrome, find his voice when young, but now he is taking over his own narrative as a young adult.
This JAMA Guide to Statistics and Methods explains the differences between risk ratios and odds ratios and when each is the more appropriate statistic to estimate measures of effect or association in research findings.
This Medical News article examines the pros and cons of national medical licensure as physicians have grappled with seeing out-of-state patients via telemedicine during the coronavirus disease 2019 pandemic.
This JAMA Patient Page explains the current definition of brain death, characteristic causes, and the conditions under which the diagnosis can be made.
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