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October 2020 - July 1883




September 15, 2020, Vol 324, No. 11, Pages 1019-1116

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2020;324(11):e200037. doi:10.1001/jama.2020.0037
Original Investigation

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;324(11):1048-1057. doi:10.1001/jama.2020.16349

This open-label randomized trial compares the effect of remdesivir (5 or 10 days) vs standard care on clinical status 11 days after treatment initiation among patients with confirmed SARS-CoV-2 infection hospitalized with moderate pneumonia (room air oxygen saturation >94%).

Association of Intra-arrest Transport vs Continued On-Scene Resuscitation With Survival to Hospital Discharge Among Patients With Out-of-Hospital Cardiac Arrest

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JAMA. 2020;324(11):1058-1067. doi:10.1001/jama.2020.14185

This study of adult patients with out-of-hospital cardiac arrest compares rates of survival to hospital discharge for those receiving EMS transport vs continued on-scene resuscitation .

Association of Routine Infant Vaccinations With Antibody Levels Among Preterm Infants

Abstract Full Text
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JAMA. 2020;324(11):1068-1077. doi:10.1001/jama.2020.12316

This cohort study evaluates IgG antibody concentrations in preterm infants after administration of combination diphtheria–tetanus toxoids–acellular pertussis–inactivated poliomyelitis–Haemophilus influenza type b–and hepatitis B (DTaP-IPV-Hib-HepB) and pneumococcal conjugate vaccines.

Research Letter

Point Prevalence Testing of Residents for SARS-CoV-2 in a Subset of Connecticut Nursing Homes

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JAMA. 2020;324(11):1101-1103. doi:10.1001/jama.2020.14984

This study describes the point prevalence of polymerase chain reaction tests positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among residents of a sample of Connecticut nursing homes in the first half of May 2020.

Association of Nursing Home Ratings on Health Inspections, Quality of Care, and Nurse Staffing With COVID-19 Cases

Abstract Full Text
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JAMA. 2020;324(11):1103-1105. doi:10.1001/jama.2020.14709

This study evaluates COVID-19 case rates between high- and low-performing nursing homes based on CMS quality measures.

Policies Among US Pediatricians for Dismissing Patients for Delaying or Refusing Vaccination

Abstract Full Text
JAMA. 2020;324(11):1105-1107. doi:10.1001/jama.2020.10658

This survey study assesses US pediatrician practices and office policies in response to parents who either refuse primary vaccinations or request to spread out individual vaccines in the primary series.

Special Communication

Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project

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JAMA. 2020;324(11):1078-1097. doi:10.1001/jama.2020.11586

This Special Communication summarizes consensus recommendations from the World Brain Death project, an international collaborative created to establish minimum standards for diagnosing brain death/death by neurologic criteria (BD/DNC) in children and adults across a broad range of settings and clinical circumstances.


Recognition of Research Participants’ Need for Autonomy: Remembering the Legacy of Henrietta Lacks

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JAMA. 2020;324(11):1027-1028. doi:10.1001/jama.2020.15936

In this Viewpoint, the NIH director and acting chief of staff discuss how Henrietta Lacks’ cervical cancer cells (HeLa) were used without her consent to create an immortal cell line used widely in modern medical research, and argue for development of policies to prevent unauthorized use of biological specimens to prevent the same thing from happening again.

Addressing Influenza Vaccination Disparities During the COVID-19 Pandemic

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JAMA. 2020;324(11):1029-1030. doi:10.1001/jama.2020.15845

In this Viewpoint, CDC scientists discuss the public health urgency of increasing influenza vaccination uptake early in the 2020-2021 season to ameliorate the threat to patients and hospitals of overlapping outbreaks, and urges clinicians to strongly recommend the vaccine and administer it to patients whenever and wherever possible.

Ethical Considerations for COVID-19 Vaccine Trials in Correctional Facilities

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JAMA. 2020;324(11):1031-1032. doi:10.1001/jama.2020.15589

This Viewpoint discusses the importance of studying coronavirus disease 2019 (COVID-19) vaccine candidates in prisoners, and proposes a framework for considering how to include them safely, ethically, and without coercion in future phase 3 vaccine trials.

The Transformational Effects of COVID-19 on Medical Education

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JAMA. 2020;324(11):1033-1034. doi:10.1001/jama.2020.14136

This Viewpoint discusses the ways medical schools adapted to the coronavirus disease 2019 (COVID-19) pandemic, allowing students to be part of the public health response, adapting curricula to educational opportunities, and modernizing means of instruction without losing time or compromising standards.

Moving the Financing of Graduate Medical Education Into the 21st Century

Abstract Full Text
JAMA. 2020;324(11):1035-1036. doi:10.1001/jama.2020.15480

This Viewpoint challenges US hospital claims that government funding to train physicians is necessary to offset costs, maintain physician supply, and keep costs low for other payers, and proposes reforms to use the monies to target known problems, such as geographic disparities in physician workforce and inadequate primary care and public health physician supply.

Legal Interventions to Address US Reductions in Life Expectancy

Abstract Full Text
JAMA. 2020;324(11):1037-1038. doi:10.1001/jama.2020.7715

This Viewpoint discusses ways that evidence-based laws can address health disparities and halt the documented reduction of life expectancy across socioeconomic groups in the US, including through regulation of hazardous products, behavioral economic incentives, wage increases, and provision of public benefits.

A Piece of My Mind

Finding His Voice

Abstract Full Text
JAMA. 2020;324(11):1039-1040. doi:10.1001/jama.2020.16334

In this narrative medicine essay, a psychologist recounts how she found her voice through writing and in patient care advocacy and research and how she helped her son, who has Schwartz-Jampel syndrome, find his voice when young, but now he is taking over his own narrative as a young adult.


Efficacy of Remdesivir in COVID-19

Abstract Full Text
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JAMA. 2020;324(11):1041-1042. doi:10.1001/jama.2020.16337

Challenging the “Scoop and Run” Model for Management of Out-of-Hospital Cardiac Arrest

Abstract Full Text
JAMA. 2020;324(11):1043-1044. doi:10.1001/jama.2020.9245

Brain Death—Moving Beyond Consistency in the Diagnostic Criteria

Abstract Full Text
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JAMA. 2020;324(11):1045-1047. doi:10.1001/jama.2020.11665
JAMA Guide to Statistics and Methods

Estimating Risk Ratios and Risk Differences: Alternatives to Odds Ratios

Abstract Full Text
JAMA. 2020;324(11):1098-1099. doi:10.1001/jama.2020.12698

This JAMA Guide to Statistics and Methods explains the differences between risk ratios and odds ratios and when each is the more appropriate statistic to estimate measures of effect or association in research findings.

Medical News & Perspectives

Telehealth Success Spurs a Call for Greater Post–COVID-19 License Portability

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JAMA. 2020;324(11):1021-1022. doi:10.1001/jama.2020.9142

This Medical News article examines the pros and cons of national medical licensure as physicians have grappled with seeing out-of-state patients via telemedicine during the coronavirus disease 2019 pandemic.

News From the Food and Drug Administration

CBD Drug Is Approved for a Third Form of Epilepsy

Abstract Full Text
JAMA. 2020;324(11):1026. doi:10.1001/jama.2020.16782

Phasing Out Potentially Hazardous Food Packaging

Abstract Full Text
JAMA. 2020;324(11):1026. doi:10.1001/jama.2020.16505

Oral Drug Approved for Spinal Muscular Atrophy

Abstract Full Text
JAMA. 2020;324(11):1026. doi:10.1001/jama.2020.16783
The JAMA Forum

New Rules for the Pandemic Era

Abstract Full Text
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JAMA. 2020;324(11):1023-1024. doi:10.1001/jama.2020.15526
Global Health

Nearly Half of Dementia Cases Could Be Prevented or Delayed

Abstract Full Text
JAMA. 2020;324(11):1025. doi:10.1001/jama.2020.16210

Interest in Global COVID-19 Vaccine Alliance Grows

Abstract Full Text
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JAMA. 2020;324(11):1025. doi:10.1001/jama.2020.16966

Routine Vaccinations Decline During Pandemic

Abstract Full Text
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JAMA. 2020;324(11):1025. doi:10.1001/jama.2020.16968
Poetry and Medicine


Abstract Full Text
JAMA. 2020;324(11):1112. doi:10.1001/jama.2020.5898
JAMA Revisited

Occultism and Insanity

Abstract Full Text
JAMA. 2020;324(11):1113. doi:10.1001/jama.2019.13620
JAMA Patient Page

Brain Death

Abstract Full Text
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JAMA. 2020;324(11):1116. doi:10.1001/jama.2020.15898

This JAMA Patient Page explains the current definition of brain death, characteristic causes, and the conditions under which the diagnosis can be made.

Comment & Response

Preemptive Therapy vs Antiviral Prophylaxis in Cytomegalovirus-Seronegative Liver Transplant Recipients With Seropositive Donors

Abstract Full Text
JAMA. 2020;324(11):1107-1108. doi:10.1001/jama.2020.11862

Preemptive Therapy vs Antiviral Prophylaxis in Cytomegalovirus-Seronegative Liver Transplant Recipients With Seropositive Donors—Reply

Abstract Full Text
JAMA. 2020;324(11):1108-1109. doi:10.1001/jama.2020.11865

Pharmacological Treatments for Tinnitus

Abstract Full Text
JAMA. 2020;324(11):1109. doi:10.1001/jama.2020.11851

Pharmacological Treatments for Tinnitus—Reply

Abstract Full Text
JAMA. 2020;324(11):1109-1110. doi:10.1001/jama.2020.11868

Benefits of Treating Obstructive Sleep Apnea

Abstract Full Text
JAMA. 2020;324(11):1110. doi:10.1001/jama.2020.11848

Benefits of Treating Obstructive Sleep Apnea—Reply

Abstract Full Text
JAMA. 2020;324(11):1110-1111. doi:10.1001/jama.2020.11856

Incorrect Axis Alignment in Figure

Abstract Full Text
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JAMA. 2020;324(11):1111. doi:10.1001/jama.2020.16387
JAMA Masthead


Abstract Full Text
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JAMA. 2020;324(11):1019-1020. doi:10.1001/jama.2019.13613