This randomized trial compares the effect of the oral soluble guanylate cyclase stimulator vericiguat (15 vs 10 mg/d) vs placebo on change in disease-specific physical function at 24 weeks among patients with HFpEF.
This randomized trial compares the safety and effect of the oral soluble guanylate cyclase stimulator praliciguat on functional capacity (peak V̇o2) at 8 weeks among patients with HFpEF.
This cancer epidemiology study characterizes lifetime cervical cancer screening prevalence in low- and middle-income countries overall and by region; per capita gross domestic product; and patient rurality, education, and household wealth.
This study updates a previous report of the estimated number of excess deaths in the US during the coronavirus disease 2019 (COVID-19) pandemic through August 1, 2020, and describes causes of those deaths and temporal relationships with state lifting of coronavirus restrictions.
This study compares levels of tumor necrosis factor α, IL-6, and IL-8 in critically ill patients with coronavirus disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution of cytokine storm to COVID-19 pathophysiology.
This cross-sectional study used nasal epithelium collected in 2015-2018 to compare expression of TMPRSS2, a facilitator of SARS-CoV-2 viral entry and spread, among Asian, Black, Latino, and White patients as well as patients of mixed race/ethnicity within a New York City health system.
This combination evidence-based and consensus clinical guideline presents recommendations and statements of good practice for the medical care of adults with Down syndrome, including screening, diagnosis, and treatment of behavioral health conditions, dementia, diabetes, cardiovascular disease, obesity, osteoporosis, atlantoaxial instability, hypothyroidism, and celiac disease.
This Viewpoint discusses ways the COVID-19 pandemic has compounded existing health, human rights, and economic disparities in communities of color and proposes a program of restorative justice in response, comprising investments in education and housing, reforms in lending practices and criminal justice, and more.
This Viewpoint discusses the mental health consequences of the coronavirus disease 2019 (COVID-19) pandemic and emphasizes the importance of developing a public health strategy to manage the waves of grief, posttraumatic stress disorder, opioid use, and other mental health consequences of coronavirus-related death and disruption.
In this Viewpoint, 2 Harvard economists estimate the cumulative financial costs of the COVID-19 pandemic in the US to date from lost domestic output and health reduction at more than $16 trillion, as a way to put the lesser costs of public health measures, such as population testing, contact tracing, and isolation, in perspective.
In this Viewpoint, the chair of the 2020 Lasker Medical Research Awards reflects on the history of the award program and its recipients as a stand-in for the 2020 awards, which are not being given because of the coronavirus disease 2019 (COVID-19) pandemic, and anticipates the most important research leading to COVID-19 treatment and control will be candidates for future recognition.
This Viewpoint discusses the emerging apparent association between COVID-19 and heart failure with preserved ejection fraction (HFpEF), and speculates on the pathophysiology and shared risk factors that may underlie the association and the possibility that SARS-CoV-2 infection may unmask or exacerbate existing HFpEF.
In this narrative medicine essay, a critical care pediatrician tells the story of knitting needle puncture in a 3-year-old boy’s chest that barely missed his main pulmonary artery, and wonders at the seemingly random difference between his operable injury and the alternative, seemingly equally probable fatal outcome.
This JAMA Insights review summarizes 2020 consensus guidelines on management of minimally abnormal cervical cancer screening results, including no abnormal pathology, atypical squamous cells of undetermined significance (ASCUS), and low-grade squamous intraepithelial lesion (LSIL) with and without positive high-risk HPV testing.
This Medical Letter review summarizes evidence about the safety and efficacy of over-the-counter melatonin-containing products as sleep aids for insomnia in children, and their role relative to standard nonpharmacological treatments.
This Medical News article discusses the right of people with dementia to vote.
This JAMA Patient Page explains palliative care and its role in the care of people living with Parkinson disease.
This JAMA Patient Page explains the role of esophageal surgery in the management of esophageal cancer and the differences between minimally invasive (laparoscopic and robotic) vs open approaches.
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