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October 2021 - July 1883

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Issue

October 27, 2020, Vol 324, No. 16, Pages 1589-1690

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2020;324(16):e200042. doi:10.1001/jama.2020.0042
Original Investigation

Effect of Catheter Ablation With Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation: The VENUS Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;324(16):1620-1628. doi:10.1001/jama.2020.16195

This randomized trial compares the effect of transcatheter pulmonary vein isolation during catheter ablation with vs without ethanol infusion into the vein of Marshall, an embryologic remnant of the left superior vena cava implicated in atrial fibrillation pathogenesis, on freedom from atrial arrhythmia at 12 months.

Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;324(16):1629-1639. doi:10.1001/jama.2020.18618

This randomized clinical trial compares the effect of regional citrate vs systemic heparin anticoagulation on dialysis filter life span and 90-day mortality among critically ill adults with acute kidney injury (AKI) receiving continuous kidney replacement therapy.

Association of Ticagrelor vs Clopidogrel With Net Adverse Clinical Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Abstract Full Text
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JAMA. 2020;324(16):1640-1650. doi:10.1001/jama.2020.16167

This cohort study compares net risk for ischemic vs hemorrhagic events at 12 months among patients treated with ticagrelor vs clopidogrel during and after percutaneous coronary intervention (PCI) management of acute coronary syndrome (ACS).

Research Letter

Nonfatal Opioid Overdoses at an Urban Emergency Department During the COVID-19 Pandemic

Abstract Full Text
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JAMA. 2020;324(16):1673-1674. doi:10.1001/jama.2020.17477

This study compares the numbers of nonfatal, unintentional opioid-related opioid overdoses presenting to a US urban emergency department during the early months of the coronavirus disease 2019 (COVID-19) pandemic (March-June 2020) vs 2019, overall and by age, race/ethnicity, and insurance status.

Analysis of Drug Test Results Before and After the US Declaration of a National Emergency Concerning the COVID-19 Outbreak

Abstract Full Text
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JAMA. 2020;324(16):1674-1677. doi:10.1001/jama.2020.17694

This substance use epidemiology study uses a commercial urine drug testing (UDT) service’s data to compare UDT results for cocaine, fentanyl, heroin, and methamphetamine before vs after US declaration of coronavirus disease 2019 (COVID-19) as a national emergency among patients diagnosed with or at risk of substance use disorders.

Change in Donor Characteristics and Antibodies to SARS-CoV-2 in Donated Blood in the US, June-August 2020

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JAMA. 2020;324(16):1677-1679. doi:10.1001/jama.2020.18598

This study describes changes in blood donor demographics and seroreactivity after testing of blood donations for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies began and was publicized in the US in mid-June 2020.

Special Communication

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society–USA Panel

Abstract Full Text
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JAMA. 2020;324(16):1651-1669. doi:10.1001/jama.2020.17025

This guideline from the International Antiviral (formerly AIDS) Society–USA updates practice recommendations for managing HIV infection including when to initiate antiviral therapy, how to monitor patients’ response, when to change antiviral regimens, and use of preexposure prophylaxis (PrEP) to prevent infection in those at risk.

Viewpoint

Fairly Prioritizing Groups for Access to COVID-19 Vaccines

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JAMA. 2020;324(16):1601-1602. doi:10.1001/jama.2020.18513

This Viewpoint proposes that ethical principles of preventing harm, helping disadvantaged populations, and achieving equal treatment should guide COVID-19 vaccine distribution, supporting initial allocation to health care workers, people in high-risk occupations and housing, and those with high-risk medical conditions.

De-adopting Low-Value Care: Evidence, Eminence, and Economics

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JAMA. 2020;324(16):1603-1604. doi:10.1001/jama.2020.17534

This Viewpoint proposes that varying combinations of evidence, physician influence, and economics guide the continuation or de-adoption of low-value health services and can help organize and prioritize policy initiatives to drive down the prevalence of wasteful care.

Extreme Wildfires—A Growing Population Health and Planetary Problem

Abstract Full Text
JAMA. 2020;324(16):1605-1606. doi:10.1001/jama.2020.19334

This Viewpoint uses findings from a June 2019 National Academies of Sciences, Engineering, and Medicine (NASEM) workshop report and subsequent data to summarize known environmental and health effects of extreme wildfires, emphasizing their differential adverse effects on low-income, non–English-speaking, and other vulnerable communities.

Revisiting the Roles of Primary Care Clinicians in Genetic Medicine

Abstract Full Text
JAMA. 2020;324(16):1607-1608. doi:10.1001/jama.2020.18745

This Viewpoint describes 4 approaches for primary care clinicians to incorporate genetics care into their practices, and the systems-level interventions needed to operationalize them, including collecting a family history, initiating genomic testing and diagnostic workup, referral to genetics subspecialists, and monitoring disease surveillance.

Nutrient Warnings on Unhealthy Foods

Abstract Full Text
JAMA. 2020;324(16):1609-1610. doi:10.1001/jama.2020.18941

This Viewpoint argues for inclusion of simply worded nutrition warnings on foods with excessive levels of sugar, sodium, and saturated fat, discussing international experience with the practice and its potential to incentivize healthier food products and reduce health inequities.

A Piece of My Mind

Out of the Park

Abstract Full Text
JAMA. 2020;324(16):1611-1612. doi:10.1001/jama.2020.20407

In this narrative medicine essay, a surgical oncologist describes the erosion of her confidence when patients and colleagues question her abilities or ignore her contributions based on her diminutive stature and sex and suggests that colleagues offer encouragement and praise to help stay further damage.

Editorial

Net Adverse Clinical Events With Antiplatelet Therapy in Acute Coronary Syndromes

Abstract Full Text
JAMA. 2020;324(16):1613-1615. doi:10.1001/jama.2020.16238

The Opioid Epidemic During the COVID-19 Pandemic

Abstract Full Text
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JAMA. 2020;324(16):1615-1617. doi:10.1001/jama.2020.18543

Sophisticated Purchasing of Pharmaceuticals: Learning From Other Countries

Abstract Full Text
JAMA. 2020;324(16):1617-1619. doi:10.1001/jama.2020.15072
JAMA Guide to Statistics and Methods

Worst-Rank Score Methods—A Nonparametric Approach to Informatively Missing Data

Abstract Full Text
JAMA. 2020;324(16):1670-1671. doi:10.1001/jama.2020.7709

This JAMA Guide to Statistics and Methods explains worst-rank score methods, a nonparametric statistical technique that assigns worst-case outcomes for patients with missing data to account for missingness that may reflect an adverse change in patient status (informative rather than random missingness).

Medical News & Perspectives

Telephone Visits Surge During the Pandemic, but Will They Last?

Abstract Full Text
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JAMA. 2020;324(16):1593-1595. doi:10.1001/jama.2020.17201

This Medical News article describes the use of telephone visits to deliver care during the pandemic.

The JAMA Forum

Financial Stability as a Goal of Payment Reform—A Lesson From COVID-19

Abstract Full Text
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JAMA. 2020;324(16):1596-1597. doi:10.1001/jama.2020.18343
News From the Centers for Disease Control and Prevention

Health Care Worker SARS-CoV-2 Infection Is Flying Under the Radar

Abstract Full Text
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JAMA. 2020;324(16):1600. doi:10.1001/jama.2020.19554

Shifting Hydroxychloroquine Patterns Raise Concern

Abstract Full Text
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JAMA. 2020;324(16):1600. doi:10.1001/jama.2020.20311
Clinical Trials Update

Vitamin D and Calcium Prevent Recurrent Vertigo

Abstract Full Text
JAMA. 2020;324(16):1599. doi:10.1001/jama.2020.18695

No Mortality Differences Among Localized Prostate Cancer Treatments

Abstract Full Text
JAMA. 2020;324(16):1599. doi:10.1001/jama.2020.20644

Daily Aspirin Increases Gastrointestinal Bleeding Among Older Adults

Abstract Full Text
JAMA. 2020;324(16):1599. doi:10.1001/jama.2020.20645

Colchicine Reduces Cardiovascular Events in Chronic Coronary Disease

Abstract Full Text
JAMA. 2020;324(16):1599. doi:10.1001/jama.2020.20646

Continuing Prednisone Offers Stable Rheumatoid Arthritis Control

Abstract Full Text
JAMA. 2020;324(16):1599. doi:10.1001/jama.2020.20647
Health Agencies Update

Substance Use Disorder Linked to Higher COVID-19 Risk

Abstract Full Text
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JAMA. 2020;324(16):1598. doi:10.1001/jama.2020.19686

US Drug Use Survey Uncovers Both Promising and Concerning Trends

Abstract Full Text
JAMA. 2020;324(16):1598. doi:10.1001/jama.2020.20622

Rising Rates of ED Visits for Suicidal Ideation, Suicide Attempt

Abstract Full Text
JAMA. 2020;324(16):1598. doi:10.1001/jama.2020.20623
The Arts and Medicine

Trains and Outer Space—The Unique Worlds Within Autism

Abstract Full Text
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JAMA. 2020;324(16):1591-1592. doi:10.1001/jama.2020.19051

This Arts and Medicine feature presents “Outer Space”, a neo-punk song written, played, and produced by a practicing neurogenetics psychiatrist to honor the brilliance of people with autism spectrum disorder and their families.

Poetry and Medicine

Palliative Care Consult

Abstract Full Text
JAMA. 2020;324(16):1684. doi:10.1001/jama.2020.12148
JAMA Revisited
JAMA Patient Page

Carotid Artery Stenting

Abstract Full Text
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JAMA. 2020;324(16):1690. doi:10.1001/jama.2020.10426

This JAMA Patient Page describes the use of the carotid artery stenting procedure to reduce the risk of stroke in patients with carotid artery atherosclerosis.

Comment & Response

Evaluating Non–Statistically Significant Results From Trials in Practice

Abstract Full Text
JAMA. 2020;324(16):1679. doi:10.1001/jama.2020.15645

Evaluating Non–Statistically Significant Results From Trials in Practice

Abstract Full Text
JAMA. 2020;324(16):1679-1680. doi:10.1001/jama.2020.15648

Evaluating Non–Statistically Significant Results From Trials in Practice—Reply

Abstract Full Text
JAMA. 2020;324(16):1680. doi:10.1001/jama.2020.15657

Polysocial Risk Scores for Assessing Social Determinants of Health

Abstract Full Text
JAMA. 2020;324(16):1680-1681. doi:10.1001/jama.2020.15699

Polysocial Risk Scores for Assessing Social Determinants of Health—Reply

Abstract Full Text
JAMA. 2020;324(16):1681-1682. doi:10.1001/jama.2020.15702

Deprescribing Antihypertensive Medication in Elderly Adults

Abstract Full Text
JAMA. 2020;324(16):1682. doi:10.1001/jama.2020.16438

Deprescribing Antihypertensive Medication in Elderly Adults—Reply

Abstract Full Text
JAMA. 2020;324(16):1682-1683. doi:10.1001/jama.2020.16441
Correction

Error in Table

Abstract Full Text
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JAMA. 2020;324(16):1683. doi:10.1001/jama.2020.20143
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2020;324(16):1589-1590. doi:10.1001/jama.2019.13668
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