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January 2021 - July 1883




November 17, 2020, Vol 324, No. 19, Pages 1925-2006

In This Issue of JAMA

Audio Highlights

Abstract Full Text
free access online only has audio
JAMA. 2020;324(19):e200045. doi:10.1001/jama.2020.0045
Original Investigation

Effect of an Emergency Department Care Bundle on 30-Day Hospital Discharge and Survival Among Elderly Patients With Acute Heart Failure: The ELISABETH Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;324(19):1948-1956. doi:10.1001/jama.2020.19378

This unblinded cluster randomized trial compares the effects of an emergency department (ED)–based comprehensive, guideline-recommended care bundle vs usual care on the number of days alive and out of the hospital at 30 days in older patients with acute heart failure cared for at French hospitals.

Detection of Pathogenic Variants With Germline Genetic Testing Using Deep Learning vs Standard Methods in Patients With Prostate Cancer and Melanoma

Abstract Full Text
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JAMA. 2020;324(19):1957-1969. doi:10.1001/jama.2020.20457

This study compares pathogenic variant detection accuracy in cancer-disposition genes of prostate cancer and melanoma cohort biopsy samples using deep learning vs standard genetic analysis methods.

Association of Childhood Lead Exposure With MRI Measurements of Structural Brain Integrity in Midlife

Abstract Full Text
JAMA. 2020;324(19):1970-1979. doi:10.1001/jama.2020.19998

This study examines the association of blood lead levels in childhood with MRI measures of brain integrity as well as cognitive function assessments at age 45 years in a New Zealand birth cohort.

Research Letter

Financial Penalties Imposed on Large Pharmaceutical Firms for Illegal Activities

Abstract Full Text
JAMA. 2020;324(19):1995-1997. doi:10.1001/jama.2020.18740

This study describes financial penalties levied on pharmaceutical companies for illegal activities by type of activity and dollar value between 2003 and 2016.


Preventing the Spread of SARS-CoV-2 With Masks and Other “Low-tech” Interventions

Abstract Full Text
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JAMA. 2020;324(19):1935-1936. doi:10.1001/jama.2020.21946

In this Viewpoint, Anthony Fauci and colleagues at NIAID emphasize the continued importance of low-tech public health practices, such as wearing masks, limiting large gatherings, hand washing, and physical distancing, to help control the COVID-19 pandemic even after safe and effective vaccines become available until distribution and uptake of vaccines confer herd immunity on a population level.

Postapproval Vaccine Safety Surveillance for COVID-19 Vaccines in the US

Abstract Full Text
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JAMA. 2020;324(19):1937-1938. doi:10.1001/jama.2020.19692

This Viewpoint reviews systems in place to monitor postlicensure vaccine safety, and recommends harmonizing end points and protocols across vaccine trials and surveillance systems to enable timely identification and reliable evaluation of potential adverse events.

Postlicensure Evaluation of COVID-19 Vaccines

Abstract Full Text
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JAMA. 2020;324(19):1939-1940. doi:10.1001/jama.2020.19328

This Viewpoint explains the “test-negative” modified case-control design commonly used for evaluating vaccine effectiveness, describes why it may be lead to biased estimates of COVID-19 vaccine effectiveness in patients with severe illness more likely to test negative, and proposes potential approaches to correcting the bias, including incorporation of clinical assessment of cases.

Heritable Human Genome Editing: The International Commission Report

Abstract Full Text
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JAMA. 2020;324(19):1941-1942. doi:10.1001/jama.2020.19059

This Viewpoint summarizes the report of the International Commission on the Clinical Use of Human Germline Genome Editing sponsored by the US National Academy of Medicine and the UK Royal Society, enumerating technical, regulatory, and ethical standards that need to be met before HHGE can be used on human embryos.

A Piece of My Mind

Shear Forces

Abstract Full Text
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JAMA. 2020;324(19):1943-1944. doi:10.1001/jama.2020.21746

In this narrative medicine essay, an internist shares how the COVID-19 pandemic disrupted the work-life balance she had attained and how the metaphor of aortic dissection—shear forces tearing arterial layers apart, managed with blood pressure—gave her a means to imagine how to reduce the opposing forces in her life on the way toward equilibrium.


Bioinformatics, Sequencing Accuracy, and the Credibility of Clinical Genomics

Abstract Full Text
JAMA. 2020;324(19):1945-1947. doi:10.1001/jama.2020.19939

Bladder Cancer: A Review

Abstract Full Text
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JAMA. 2020;324(19):1980-1991. doi:10.1001/jama.2020.17598

This narrative review summarizes recent advances in the diagnosis and management of bladder cancer, including updates on its epidemiology, pathophysiology, molecular biology, and developments in surgical procedures and targeted treatments.

JAMA Clinical Challenge

Dyschromic Nails, Exertional Dyspnea, and Lower Extremity Edema

Abstract Full Text
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JAMA. 2020;324(19):1992-1993. doi:10.1001/jama.2020.14648

A 70-year-old man with a 2-year history of nasal congestion, rhinorrhea, and chronic cough developed yellow discoloration and thickening of his fingernails and toenails and progressive exertional dyspnea and edema of both lower extremities. ANA was positive (1:160, nucleolar pattern), a chest radiograph was unrevealing, and sinus CT showed bilateral maxillary and posterior ethmoidal sinusitis. What is the diagnosis and what would you do next?

Medical News & Perspectives

Nursing Homes’ Next Test—Vaccinating Workers Against COVID-19

Abstract Full Text
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JAMA. 2020;324(19):1928-1930. doi:10.1001/jama.2020.21354

This story examines the potential roadblocks to vaccinating millions of long-term care workers against COVID-19, a task that is considered to be a critical step in protecting vulnerable nursing home residents.

News From the Food and Drug Administration

Breast Implant Manufacturers Get Labeling Guidance

Abstract Full Text
JAMA. 2020;324(19):1934. doi:10.1001/jama.2020.22066

FDA Expands Food Safety Collaboration With Mexico

Abstract Full Text
JAMA. 2020;324(19):1934. doi:10.1001/jama.2020.21458

Warning Concerns Respirator Decontamination System

Abstract Full Text
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JAMA. 2020;324(19):1934. doi:10.1001/jama.2020.22068
The JAMA Forum

To Truly Build the Affordable Care Act Into Universal Coverage, More Creativity Is Needed

Abstract Full Text
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JAMA. 2020;324(19):1931-1932. doi:10.1001/jama.2020.21609
Global Health

Dried Blood Spots May Offer Route to Wider Antibody Testing

Abstract Full Text
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JAMA. 2020;324(19):1933. doi:10.1001/jama.2020.21109

Partnership to Make 120 Million COVID-19 Rapid Tests Available

Abstract Full Text
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JAMA. 2020;324(19):1933. doi:10.1001/jama.2020.22082

Global Mental Health Services Are Collapsing as Demand Grows

Abstract Full Text
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JAMA. 2020;324(19):1933. doi:10.1001/jama.2020.22085
Poetry and Medicine


Abstract Full Text
JAMA. 2020;324(19):2001. doi:10.1001/jama.2020.14356
JAMA Revisited
JAMA Patient Page

Bladder Cancer

Abstract Full Text
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JAMA. 2020;324(19):2006. doi:10.1001/jama.2020.17601

This JAMA Patient Page summarizes treatment options for early, invasive, and advanced bladder cancer.

Comment & Response

Assessing Alternative Payment Models

Abstract Full Text
JAMA. 2020;324(19):1997-1998. doi:10.1001/jama.2020.19006

Assessing Alternative Payment Models—Reply

Abstract Full Text
JAMA. 2020;324(19):1998. doi:10.1001/jama.2020.19021

Testing Clinical Prediction Models

Abstract Full Text
JAMA. 2020;324(19):1998-1999. doi:10.1001/jama.2020.19392

Testing Clinical Prediction Models

Abstract Full Text
JAMA. 2020;324(19):1999-2000. doi:10.1001/jama.2020.19389

Testing Clinical Prediction Models—Reply

Abstract Full Text
JAMA. 2020;324(19):2000. doi:10.1001/jama.2020.19413
JAMA Masthead


Abstract Full Text
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JAMA. 2020;324(19):1925-1926. doi:10.1001/jama.2019.13701