This randomized trial compares the effects of hydroxychloroquine vs placebo on clinical status at 14 days (home, requiring noninvasive or invasive ventilation or extracorporeal membrane oxygenation, hospitalized, died) among adults hospitalized with coronavirus disease 2019 (COVID-19).
This crossover randomized clinical trial evaluated driving test performance of healthy young adult volunteers after vaporized consumption of cannabis (Δ9-tetrahydrocannabinol [THC] and cannabidiol [CBD]) vs placebo.
This case-control study uses national hospital and immunization records in Portugal to estimates the difference in incidence of invasive group B meningococcal disease among children and adolescents who were immunized vs not immunized with 4CMenB, a 4-component meningococcus group B vaccine licensed in 2013.
This study uses IBM MarketScan database data to describe trends in zolpidem and low-dose trazodone dispensing among adults with employer-sponsored insurance or Medicare supplemental plans between 2011 and 2018, before and after a 2017 clinical practice guideline discouraged trazodone use for insomnia.
In this Viewpoint, Fauci and NIAID colleagues review leading candidates for treatment of mild to moderate coronavirus disease 2019 (COVID-19) to prevent disease progression and longer-term complications, including emerging antiviral drugs, immune-modulating agents, and antibody-based therapies, and the challenges of developing randomized trials to rapidly evaluate the safety and efficacy of each.
This Viewpoint discusses questions about clinical indication, supply, distribution, and cost and coverage that will need to be resolved if monoclonal antibodies are be granted Emergency Use Authorization or licensure and become available as treatment for COVID-19.
This Viewpoint proposes criteria for more effective COVID-19 testing strategies to manage population transmission, including use of rapid antigen tests and self-administered nasal and salivary tests, emphasizing that more effective testing alone cannot control the pandemic without continued public health interventions, such as mask wearing, physical distancing, and avoidance of large gatherings.
This Viewpoint reviews the rare incidence of nosocomial SARS-CoV-2 infection and discusses ways it can be minimized, including use of surgical masks, proper ventilation, physical distancing, eye protection, regular testing, and the availability of sick leave for health care workers.
This Viewpoint looks at the range of medical and public health issues that could be adversely affected by appointment of Justice Amy Coney Barrett to the US Supreme Court, including weakening or elimination of the Affordable Care Act, Medicaid work requirements that could reduce eligibility, and reduced reproductive rights and governmental public health emergency powers.
In this narrative medicine essay a medical student recalls discovering the power of meaningful palliative care, contrasting patients’ relief from suffering through caring and comfort with her father’s awful experience of pain and neglect in his closing days.
This narrative review summarizes the etiologies of pediatric hearing loss, screening strategies for identifying it early, consequences of delayed diagnosis, and diagnosis and management of the condition, with a detailed discussion of criteria for choice of hearing devices to remediate hearing impairment.
This JAMA Insights Clinical Update discusses evidence for the efficacy and safety of gastric balloon systems for weight loss, and their clinical indications as part of a multidisciplinary approach to weight management in patients who are not candidates for bariatric surgery.
This JAMA Clinical Guidelines Synopsis summarizes the US Multi-Society Task Force on Colorectal Cancer’s 2020 recommendations for follow-up after colonoscopy and polypectomy.
This Medical News article discusses the health implications of severe acute respiratory syndrome coronavirus 2 infection among young and middle-aged adults.
This Medical News feature discusses research into how cannabidiol and tetrahydrocannabinol affect driving performance.
This JAMA Patient Page describes the 3 surgical techniques used to divert urine away from the bladder as a part of surgical treatment of bladder cancer.