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September 2021 - July 1883

Decade

Year

Issue

December 1, 2020, Vol 324, No. 21, Pages 2131-2222

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2020;324(21):e200047. doi:10.1001/jama.2020.0047
Original Investigation

Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;324(21):2165-2176. doi:10.1001/jama.2020.22240

This randomized trial compares the effects of hydroxychloroquine vs placebo on clinical status at 14 days (home, requiring noninvasive or invasive ventilation or extracorporeal membrane oxygenation, hospitalized, died) among adults hospitalized with coronavirus disease 2019 (COVID-19).

Effect of Cannabidiol and Δ9-Tetrahydrocannabinol on Driving Performance: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;324(21):2177-2186. doi:10.1001/jama.2020.21218

This crossover randomized clinical trial evaluated driving test performance of healthy young adult volunteers after vaporized consumption of cannabis (Δ9-tetrahydrocannabinol [THC] and cannabidiol [CBD]) vs placebo.

Association of Use of a Meningococcus Group B Vaccine With Group B Invasive Meningococcal Disease Among Children in Portugal

Abstract Full Text
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JAMA. 2020;324(21):2187-2194. doi:10.1001/jama.2020.20449

This case-control study uses national hospital and immunization records in Portugal to estimates the difference in incidence of invasive group B meningococcal disease among children and adolescents who were immunized vs not immunized with 4CMenB, a 4-component meningococcus group B vaccine licensed in 2013.

Research Letter

Trends in Dispensing of Zolpidem and Low-Dose Trazodone Among Commercially Insured Adults in the United States, 2011-2018

Abstract Full Text
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JAMA. 2020;324(21):2211-2213. doi:10.1001/jama.2020.19224

This study uses IBM MarketScan database data to describe trends in zolpidem and low-dose trazodone dispensing among adults with employer-sponsored insurance or Medicare supplemental plans between 2011 and 2018, before and after a 2017 clinical practice guideline discouraged trazodone use for insomnia.

Viewpoint

Therapy for Early COVID-19: A Critical Need

Abstract Full Text
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JAMA. 2020;324(21):2149-2150. doi:10.1001/jama.2020.22813

In this Viewpoint, Fauci and NIAID colleagues review leading candidates for treatment of mild to moderate coronavirus disease 2019 (COVID-19) to prevent disease progression and longer-term complications, including emerging antiviral drugs, immune-modulating agents, and antibody-based therapies, and the challenges of developing randomized trials to rapidly evaluate the safety and efficacy of each.

The Challenges Ahead With Monoclonal Antibodies: From Authorization to Access

Abstract Full Text
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JAMA. 2020;324(21):2151-2152. doi:10.1001/jama.2020.21872

This Viewpoint discusses questions about clinical indication, supply, distribution, and cost and coverage that will need to be resolved if monoclonal antibodies are be granted Emergency Use Authorization or licensure and become available as treatment for COVID-19.

The Need for More and Better Testing for COVID-19

Abstract Full Text
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JAMA. 2020;324(21):2153-2154. doi:10.1001/jama.2020.21694

This Viewpoint proposes criteria for more effective COVID-19 testing strategies to manage population transmission, including use of rapid antigen tests and self-administered nasal and salivary tests, emphasizing that more effective testing alone cannot control the pandemic without continued public health interventions, such as mask wearing, physical distancing, and avoidance of large gatherings.

Hospital-Acquired SARS-CoV-2 Infection: Lessons for Public Health

Abstract Full Text
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JAMA. 2020;324(21):2155-2156. doi:10.1001/jama.2020.21399

This Viewpoint reviews the rare incidence of nosocomial SARS-CoV-2 infection and discusses ways it can be minimized, including use of surgical masks, proper ventilation, physical distancing, eye protection, regular testing, and the availability of sick leave for health care workers.

Health Policy in the Supreme Court and a New Conservative Majority

Abstract Full Text
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JAMA. 2020;324(21):2157-2158. doi:10.1001/jama.2020.21987

This Viewpoint looks at the range of medical and public health issues that could be adversely affected by appointment of Justice Amy Coney Barrett to the US Supreme Court, including weakening or elimination of the Affordable Care Act, Medicaid work requirements that could reduce eligibility, and reduced reproductive rights and governmental public health emergency powers.

A Piece of My Mind

Always More to Be Done

Abstract Full Text
JAMA. 2020;324(21):2159-2160. doi:10.1001/jama.2020.22783

In this narrative medicine essay a medical student recalls discovering the power of meaningful palliative care, contrasting patients’ relief from suffering through caring and comfort with her father’s awful experience of pain and neglect in his closing days.

Editorial

Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science

Abstract Full Text
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JAMA. 2020;324(21):2161-2162. doi:10.1001/jama.2020.22389

Cannabis and Impaired Driving

Abstract Full Text
JAMA. 2020;324(21):2163-2164. doi:10.1001/jama.2020.18544
Review

Hearing Loss in Children: A Review

Abstract Full Text
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JAMA. 2020;324(21):2195-2205. doi:10.1001/jama.2020.17647

This narrative review summarizes the etiologies of pediatric hearing loss, screening strategies for identifying it early, consequences of delayed diagnosis, and diagnosis and management of the condition, with a detailed discussion of criteria for choice of hearing devices to remediate hearing impairment.

JAMA Insights

Clinical Update

Gastric Balloons for Weight Loss in 2020

Abstract Full Text
JAMA. 2020;324(21):2206-2207. doi:10.1001/jama.2020.14862

This JAMA Insights Clinical Update discusses evidence for the efficacy and safety of gastric balloon systems for weight loss, and their clinical indications as part of a multidisciplinary approach to weight management in patients who are not candidates for bariatric surgery.

JAMA Clinical Guidelines Synopsis

Recommendations for Follow-up Colonoscopy After Polypectomy

Abstract Full Text
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JAMA. 2020;324(21):2208-2209. doi:10.1001/jama.2020.15001

This JAMA Clinical Guidelines Synopsis summarizes the US Multi-Society Task Force on Colorectal Cancer’s 2020 recommendations for follow-up after colonoscopy and polypectomy.

Medical News & Perspectives

Younger Adults Caught in COVID-19 Crosshairs as Demographics Shift

Abstract Full Text
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JAMA. 2020;324(21):2141-2143. doi:10.1001/jama.2020.21913

This Medical News article discusses the health implications of severe acute respiratory syndrome coronavirus 2 infection among young and middle-aged adults.

Driving Under the Influence of CBD or THC—Is There a Difference?

Abstract Full Text
has audio
JAMA. 2020;324(21):2144-2145. doi:10.1001/jama.2020.22181

This Medical News feature discusses research into how cannabidiol and tetrahydrocannabinol affect driving performance.

News From the Food and Drug Administration

Essential Medicines Identified for Future Public Health Emergencies

Abstract Full Text
JAMA. 2020;324(21):2147. doi:10.1001/jama.2020.23157

New Partnership Aims to Intercept Illegal Drugs and Devices

Abstract Full Text
JAMA. 2020;324(21):2147. doi:10.1001/jama.2020.22864

Ivermectin Lotion for Head Lice No Longer Needs a Prescription

Abstract Full Text
JAMA. 2020;324(21):2147. doi:10.1001/jama.2020.23159
Bench to Bedside

How Targeting Fat Cells’ Estrogen Receptors Could Fight Obesity

Abstract Full Text
JAMA. 2020;324(21):2146. doi:10.1001/jama.2020.22148
Poetry and Medicine

Life Review

Abstract Full Text
JAMA. 2020;324(21):2217. doi:10.1001/jama.2020.17389
JAMA Revisited

The Right to Strike

Abstract Full Text
JAMA. 2020;324(21):2218. doi:10.1001/jama.2019.13730
JAMA Patient Page

Urinary Diversion

Abstract Full Text
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JAMA. 2020;324(21):2222. doi:10.1001/jama.2020.17604

This JAMA Patient Page describes the 3 surgical techniques used to divert urine away from the bladder as a part of surgical treatment of bladder cancer.

Comment & Response

Prejudices of a Referenced Philosopher

Abstract Full Text
JAMA. 2020;324(21):2213-2214. doi:10.1001/jama.2020.20083

Prejudices of a Referenced Philosopher—Reply

Abstract Full Text
JAMA. 2020;324(21):2214. doi:10.1001/jama.2020.20086

Developments in Heart Failure With Reduced Ejection Fraction

Abstract Full Text
JAMA. 2020;324(21):2214-2215. doi:10.1001/jama.2020.20542

Developments in Heart Failure With Reduced Ejection Fraction

Abstract Full Text
JAMA. 2020;324(21):2215. doi:10.1001/jama.2020.20545

Developments in Heart Failure With Reduced Ejection Fraction—Reply

Abstract Full Text
JAMA. 2020;324(21):2215-2216. doi:10.1001/jama.2020.20548
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2020;324(21):2131-2132. doi:10.1001/jama.2019.13723
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