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August 2022 - July 1883




December 8, 2020, Vol 324, No. 22, Pages 2238-2334

In This Issue of JAMA

Audio Highlights

Abstract Full Text
free access online only has audio
JAMA. 2020;324(22):e200048. doi:10.1001/jama.2020.0048
Original Investigation

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;324(22):2268-2280. doi:10.1001/jama.2020.22258

This randomized trial examines the effects on cardiovascular outcomes of a carboxylic acid formulation of EPA and DHA (omega-3 CA) with documented favorable effects on lipid and inflammatory markers in patients with atherogenic dyslipidemia and high cardiovascular risk.

Effect of Co-trimoxazole (Trimethoprim-Sulfamethoxazole) vs Placebo on Death, Lung Transplant, or Hospital Admission in Patients With Moderate and Severe Idiopathic Pulmonary Fibrosis: The EME-TIPAC Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;324(22):2282-2291. doi:10.1001/jama.2020.22960

This randomized clinical trial compares the effects of co-trimoxazole (trimethoprim-sulfamethoxazole [TMP-SMX]) vs placebo on time to death, lung transplant, or hospital admission in patients with moderate or severe idiopathic pulmonary fibrosis (IPF).

Preliminary Communication

Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;324(22):2292-2300. doi:10.1001/jama.2020.22760

This randomized trial compares the effects of fluvoxamine, a selective serotonin reuptake inhibitor with immunomodulatory effects vs placebo on a composite of dyspnea or pneumonia and oxygen desaturation among adult outpatients with polymerase chain reaction–confirmed mild coronavirus disease 2019 (COVID-19) illness.

Research Letter

Peripheral Oxygen Saturation in Older Persons Wearing Nonmedical Face Masks in Community Settings

Abstract Full Text
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JAMA. 2020;324(22):2323-2324. doi:10.1001/jama.2020.21905

This study describes changes in portable oximeter–measured peripheral oxygen saturation (Spo2 or O2sat) in older adults before, during, and after wearing a 3-layer plane-shaped disposable nonmedical face mask widely used to protect against COVID-19.

Neurodevelopmental Outcomes at Age 5 Years After Prophylactic Early High-Dose Recombinant Human Erythropoietin for Neuroprotection in Very Preterm Infants

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JAMA. 2020;324(22):2324-2327. doi:10.1001/jama.2020.19395

This study reports 5-year neurodevelopmental outcomes for Swiss children born before 32 weeks’ gestation and randomized at birth to receive early high-dose recombinant human erythropoietin (rhEpo) vs placebo.

Special Communication

Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program

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JAMA. 2020;324(22):2301-2317. doi:10.1001/jama.2020.21974

This guideline summarizes updated recommendations for management of asthma in adolescents and adults, focusing on evidence for use of inhaled corticosteroids (ICSs), add-on long-acting muscarinic antagonists (LAMAs), fractional exhaled nitric oxide (FeNO) testing, indoor allergen mitigation, immunotherapy, and evidence against use of bronchial thermoplasty.


A Proposed Framework and Timeline of the Spectrum of Disease Due to SARS-CoV-2 Infection: Illness Beyond Acute Infection and Public Health Implications

Abstract Full Text
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JAMA. 2020;324(22):2251-2252. doi:10.1001/jama.2020.22717

This Viewpoint uses clinical observations of the natural course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to propose 3 phases of illness: acute infection (what people commonly refer to with the COVID-19 designation); postacute hyperinflammatory illness (referred to clinically as multisystem inflammatory syndrome); and late inflammatory sequelae, manifest as enduring cardiac, neurological, and psychological symptoms.

Older Adults and the Mental Health Effects of COVID-19

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JAMA. 2020;324(22):2253-2254. doi:10.1001/jama.2020.21753

This Viewpoint summarizes evidence suggesting that, counter to expectation, older adults as a group may be more resilient to the anxiety, depression, and stress-related mental health disorders characteristic of younger populations during the COVID-19 pandemic.

Science Denial and COVID Conspiracy Theories: Potential Neurological Mechanisms and Possible Responses

Abstract Full Text
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JAMA. 2020;324(22):2255-2256. doi:10.1001/jama.2020.21332

This Viewpoint discusses possible parallels between the distortion in sensory information and faulty monitoring of ideas characteristic of some patients with neurodegenerative diseases (dementia with Lewy bodies and Capgras syndrome, frontotemporal dementia) and the creation and maintenance of false conspiratorial beliefs about the COVID-19 pandemic in healthy populations that has hobbled an effective national response in the US.

COVID-19, Decarceration, and the Role of Clinicians, Health Systems, and Payers: A Report From the National Academy of Sciences, Engineering, and Medicine

Abstract Full Text
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JAMA. 2020;324(22):2257-2258. doi:10.1001/jama.2020.22109

This Viewpoint summarizes a National Academy of Sciences, Engineering, and Medicine (NASEM) consensus panel report recommending ways to reduce populations in prisons and jails as a means to mitigate SARS-CoV-2 transmission and the roles clinicians, health systems, and insurers can play in in process.

Improving Care for Heart Failure With Reduced Ejection Fraction—A Potential Polypill-Based Strategy

Abstract Full Text
JAMA. 2020;324(22):2259-2260. doi:10.1001/jama.2020.21395

This Viewpoint proposes that a polypill combination of a β-blocker, renin angiotensin inhibitor, mineralocorticoid receptor antagonist, and sodium-glucose cotransporter 2 inhibitor might be the most efficient way to deliver guideline-directed HFrEF therapy, and proposes a research roadmap to design and evaluate the pill and implementation strategies for getting it to patients.

A Piece of My Mind


Abstract Full Text
JAMA. 2020;324(22):2261. doi:10.1001/jama.2020.23077

In this narrative medicine essay, a senior faculty investigator describes common reactions to her visible disability and calls for recruitment of a diverse workforce into academic medicine’s workforce and leadership positions to normalize physical differences immaterial to the pursuit of outstanding science and patient care.


Effects of Omega-3 Fatty Acids on Major Adverse Cardiovascular Events: What Matters Most: the Drug, the Dose, or the Placebo?

Abstract Full Text
JAMA. 2020;324(22):2262-2264. doi:10.1001/jama.2020.22387

Evolving Strategies for Long-term Asthma Management

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JAMA. 2020;324(22):2265-2267. doi:10.1001/jama.2020.16895
JAMA Insights

Clinical Update

Preparing for the 2020-2021 Influenza Season

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JAMA. 2020;324(22):2318-2319. doi:10.1001/jama.2020.21849

This JAMA Insights Clinical Update discusses the importance of established influenza prevention and control measures, including influenza vaccination and antiviral treatment, as the Global North enters its first influenza season in the COVID-19 pandemic.

JAMA Diagnostic Test Interpretation

Urinary Magnesium in the Evaluation of Hypomagnesemia

Abstract Full Text
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JAMA. 2020;324(22):2320-2321. doi:10.1001/jama.2020.18400

A 63-year-old woman with type 2 diabetes was referred for refractory hypomagnesemia (1.4 mg/dL; low normal, 1.8 mg/dL). Her medications included liraglutide, metformin, lisinopril, and magnesium oxide (400 mg twice daily). A recent hemoglobin A1c level was 10.8%, and her urinary magnesium was 117 mg. How do you interpret the urine level, and what would you do next?

Editor's Note

Do Omega-3 Fatty Acids Benefit Health?

Abstract Full Text
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JAMA. 2020;324(22):2280-2281. doi:10.1001/jama.2020.22898

COVID-19 Infection—Preventing Clinical Deterioration

Abstract Full Text
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JAMA. 2020;324(22):2300. doi:10.1001/jama.2020.21720
Medical News & Perspectives

Looking to Long-term Survivors for Improved Pancreatic Cancer Treatment

Abstract Full Text
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JAMA. 2020;324(22):2242-2244. doi:10.1001/jama.2020.21717

This Medical News article examines how studying the characteristics of long-term pancreatic cancer survivors might improve treatment and boost survival for others who have the disease

The JAMA Forum

Four COVID-19 Lessons for Achieving Health Equity

Abstract Full Text
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JAMA. 2020;324(22):2245-2246. doi:10.1001/jama.2020.23553
News From the Centers for Disease Control and Prevention

Supplement Use Is Common Among Children and Adolescents

Abstract Full Text
JAMA. 2020;324(22):2248. doi:10.1001/jama.2020.23283

Pulmonary Fungal Infections Affect Patients With COVID-19

Abstract Full Text
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JAMA. 2020;324(22):2248. doi:10.1001/jama.2020.22914
Biotech Innovations

Using Smartwatch Data to Detect COVID-19 Cases Early

Abstract Full Text
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JAMA. 2020;324(22):2247. doi:10.1001/jama.2020.23696

Long-acting Cabotegravir Shot Prevents HIV Among Women

Abstract Full Text
JAMA. 2020;324(22):2247. doi:10.1001/jama.2020.23330

Neurodegenerative Dementias Are Differentiated on PET Scans

Abstract Full Text
JAMA. 2020;324(22):2247. doi:10.1001/jama.2020.23698
The Arts and Medicine

Let Me Not Be Mad—My Story of Unraveling Minds: Neuropsychiatric Self-portrait in a Convex Mirror

Abstract Full Text
JAMA. 2020;324(22):2240-2241. doi:10.1001/jama.2020.20884

This Arts and Medicine feature reviews a memoir by a pseudonymous UK neuropsychologist who, through creative telling of case histories, questions the boundaries between doctor and patient, brain and mind, language and thought, and well and unwell.

Poetry and Medicine

Notes on Perimenopause

Abstract Full Text
JAMA. 2020;324(22):2329. doi:10.1001/jama.2020.17442
JAMA Revisited

The Fly in Court

Abstract Full Text
JAMA. 2020;324(22):2330. doi:10.1001/jama.2019.13741

A Supreme Court’s Pronouncement Against the Fly

Abstract Full Text
JAMA. 2020;324(22):2330. doi:10.1001/jama.2020.21562
JAMA Patient Page

High-risk Groups for Influenza Complications

Abstract Full Text
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JAMA. 2020;324(22):2334. doi:10.1001/jama.2020.21869

This JAMA Patient Page describes the groups of people who are at high risk of complications from influenza infection, how to reduce risk through vaccination, and steps high-risk people should take if they develop influenza symptoms.

Comment & Response

Intravenous Acetaminophen in Postoperative Patients

Abstract Full Text
JAMA. 2020;324(22):2327. doi:10.1001/jama.2020.21462

Intravenous Acetaminophen in Postoperative Patients—Reply

Abstract Full Text
JAMA. 2020;324(22):2327. doi:10.1001/jama.2020.21470

Coding Errors in Study of Factors Associated With SARS-CoV-2 Antibodies in Health Care Personnel

Abstract Full Text
JAMA. 2020;324(22):2328. doi:10.1001/jama.2020.20994

Data Inaccuracies in Text and Tables

Abstract Full Text
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JAMA. 2020;324(22):2328. doi:10.1001/jama.2020.22507
JAMA Masthead


Abstract Full Text
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JAMA. 2020;324(22):2238-2239. doi:10.1001/jama.2019.13734