This randomized trial evaluates the effect of levothyroxine vs placebo on left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction and subclinical hypothyroidism.
This case series describes the clinical and laboratory characteristics of children hospitalized in England from March to May 2020 who met criteria for pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS), and compares syndrome characteristics with historical cases of Kawasaki disease (KD), KD shock syndrome, and toxic shock syndrome (TSS).
This survey study assesses US public attitudes about practices used by health care institutions to encourage philanthropic donations from grateful patients.
This case series describes clinical characteristics, treatment, and outcomes of 17 previously healthy SARS-CoV-2–infected children and adolescents with an inflammatory phenotype overlapping with but distinct from Kawasaki disease and toxic shock syndrome admitted to a New York City hospital in late April and early May 2020.
This cohort study estimates associations between mode of delivery (vaginal vs cesarean delivery) and maternal and neonatal birth outcomes among SARS-CoV-2–infected women giving birth in Spain.
This study uses publicly available FDA.gov data to characterize trends in the US Food and Drug Administration’s use of Risk Evaluation and Mitigation Strategy (REMS) programs between 2008 and 2019 and to describe the number and classes of medications included, the strategies deployed, and the risks the program was intended to mitigate.
In this Viewpoint, Berwick emphasizes that moral commitment to others, expressed through working for universal health coverage, criminal justice, and housing policy reform, climate change intervention, and more, is necessary if society is to meaningfully address adverse social determinants of health and reduce health inequalities.
This Viewpoint discusses the inequalities underlying the preferential spread of COVID-19 and of economic hardship in lower-income communities of color in the US, and sees the national protests in support of the Black Lives Matter movement as a natural consequence of those inequities and an opportunity to change the systems that create them.
This Viewpoint reviews proposed legislation to address health disparities the COVID-19 pandemic has exposed and calls for reform and redesign of the US health care system and society to address inequities that affect persons of color and other vulnerable groups.
This Viewpoint highlights the structural drivers of disadvantage and poverty that are antecedents of health inequity in the COVID-19 pandemic and proposes proportionately structural changes to how health and medical education systems operate to advance the health of individuals, communities, and their surrounding environments.
This Viewpoint discusses the necessity and prospects for health care reform in the wake of the coronavirus disease 2019 (COVID-19) pandemic, reviewing policy options to fund universal coverage, incentivize efficiencies, and reduce political opposition to change.
In this Viewpoint, John Ioannidis and colleagues discuss the proliferation of undervalidated or unvalidated clinical prediction models (CPMs) and propose an open-source repository where risk prediction scores could be updated in real time and validated as a means to facilitate identification of best-performing and reduce creation of duplicate or unhelpful models.
This Viewpoint examines whether alternative payment models are a success according to the lack of significant findings by individual demonstration projects on the one hand and the plateau of overall health care spending as a share of the gross domestic product (GDP) on the other.
This Viewpoint considers whether viral infection contributes to Alzheimer disease.
This Viewpoint discusses safety concerns surrounding unproven and unregulated regenerative medicine products—typically bone marrow, fat, placental, or umbilical cord stem cells proposed as therapies—and offers guidance about how to evaluate if the therapies meet basic Food and Drug Administration requirements for investigational agents.
In this narrative medicine essay, a primary care physician finds little solace in his medical training while caring for his 2 young daughters as a stay-at-home dad.
This narrative review summarizes evidence that addresses commonly asked questions about cardiovascular risk assessment prior to noncardiac surgery, such as the role of preoperative stress testing and medication to reduce surgical risk and the need to discontinue anticoagulants.
This JAMA Insights Clinical Update reviews indications for use of medications for primary prevention of breast cancer and the comparative effectiveness and adverse effects of selective estrogen receptor modulators (tamoxifen, raloxifene) and aromatase inhibitors (anastrozole, exemestane) for this purpose.
This Medical News article discusses Latin America’s critical shortages of medical supplies including personal protective equipment and ventilators during the coronavirus disease 2019 pandemic.
In this Medical News article, Anthony Fauci, MD, the country’s top infectious diseases expert, discusses the latest on COVID-19 and memories of a friend from another pandemic.
This JAMA Patient Page describes the indications for use of medications to reduce breast cancer risk and the benefits and risks of the 2 major drug classes, SERMs (tamoxifen, raloxifene) and aromatase inhibitors (anastrozole, exemestane).
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