This randomized trial compares the effect of intravenous acetaminophen vs placebo on duration of hypoxemia during the initial 48 postoperative hours among patients undergoing colorectal and other abdominal surgeries.
This national survey study assesses the dietary quality of lunch for students participating in the National School Lunch Program (NSLP) before and after implementation of the Healthy, Hunger-Free Kids Act, which, in 2012, aligned school lunch nutrition standards with the 2010 Dietary Guidelines for Americans.
This study reports 20-year breast cancer incidence among participants in Women’s Health Initiative (WHI) trials randomized to conjugated equine estrogen (CEE) alone or with medroxyprogesterone acetate vs placebo.
This study uses 2018 national survey data to characterize the proportion of essential workers in the US overall and living in economically vulnerable households, defined as income <$40 000 or at least 1 member uninsured or older than age 65.
This cross-sectional study investigates associations of residential building characteristics and markers of neighborhood socioeconomic status (SES) with screen-detected SARS-CoV-2 prevalence among pregnant women delivering in 2 New York City hospitals.
This study characterizes the trends in rates of SARS-CoV-2 positive test results among individuals in the Baltimore–Washington, DC area by self-reported race/ethnicity.
This study uses national pharmacy claims data to describes trends in prescriptions for HIV preexposure prophylaxis (PrEP) overall and by specialty between 2012 and 2018.
This Viewpoint proposes creation of state-level central lotteries for allocating drugs like remdesivir to hospitalized patients with COVID-19, which, if paired with demographic and outcome registry data, would enable equitable treatment allocation and facilitate actionable intelligence about the drugs’ treatment effectiveness through a natural experiment.
This Viewpoint argues that the FDA’s Emergency Use Authorization (EUA) of remdesivir missed important opportunities to mandate further study of the drug’s safety and efficacy and to require fair drug pricing, and proposes modifications to create a patient registry with required data entry for any prescription and to allow government negotiations to achieve a reasonable drug price based on shared risk-taking.
This Viewpoint discusses deficiencies in existing approaches to measuring health care quality and safety exposed by the coronavirus disease 2019 (COVID-19) pandemic and proposes process improvements, including reducing the need for manual data extraction, reducing delays between measures and reporting, and better standardizing the measures.
This Viewpoint proposes policy responses to boost influenza vaccination uptake and reduce the anticipated morbidity and mortality of an influenza–COVID-19 co-epidemic in fall 2020.
This Viewpoint reviews common cognitive biases that led health centers and the public to favor patient- over population health–oriented policy responses to the initial COVID-19 pandemic, and proposes messaging to better articulate the rationale for more effective population health responses.
This Viewpoint discusses the rationale for centralizing high-risk surgical procedures—referring patients to medical centers with more experienced surgeons to improve outcomes—and considers alternative strategies less likely to inconvenience patients and more likely to improve surgical safety with fewer trade-offs.
This Viewpoint summarizes evidence about the effects of intermittent fasting on chronic disease markers and considers potential concerns about fasting as a strategy for weight management and glycemic control in people with type 2 diabetes.
In the context of loosening criteria allowing veterans cared for within the Veterans Health Administration (VHA) health system to seek and receive nonurgent care in community settings, this Viewpoint discusses comparative access and timeliness, quality, and costs associated with the VHA vs outside facility care, and potential ramifications for the US Department of Veterans Affairs (VA) budget.
In this narrative medicine essay, an internist notes the irony of being able to go to the bedside of her dying mother and lie in her bed holding her through the night to awaken to her recovering mother only to be again banished from her.
This JAMA Guide to Statistics and Methods explains the use of regression discontinuity analysis on observational data—the difference in effect estimate between regression analyses using an exposure variable above and beneath a threshold of interest—to distinguish changes attributable to an intervention from background ecological or secular changes.
This JAMA Clinical Insights article reviews the epidemiology, diagnosis, treatment, and prevention of hepatitis A infection given an upward trend in the incidence of the disease since 2016 in the US.
A 23-year-old woman had pain, color changes, and ischemic ulcerations of the fingertips of both hands. History and examination revealed eye and mouth dryness, mild dysphagia, and dilated nailfold capillaries; antinuclear antibodies were positive (≥1:640) in a composite nuclear and nucleolar fine speckled staining pattern, as were anti-Ro52, anti-Ro60, and anti–Scl-70 antibodies. What is the diagnosis and what would you do next?
This Medical News article discusses the financial and logistical impact of COVID-19 on medical practices.
This Arts and Medicine feature discusses the ongoing relevance of Sinclair Lewis’ 1925 novel Arrowsmith to unresolved questions of research, treatment, prevention, and mitigation of the 2020 COVID-19 pandemic.
This JAMA Patient Page reviews some of the actions bytanders, first responders, and medical personnel can take at the scene of a trauma (eg, car crash, gunshot, drowning) to stabilize a patient for transportation to a trauma center hospital.
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