This randomized trial compares the effects of convalescent plasma therapy with standard care vs standard care alone on time to clinical improvement among patients with severe or life-threatening COVID-19 disease in China.
This randomized clinical trial compares the effects of vitamin D₃ supplementation vs placebo on depression risk and mood scores in men and women aged 50 years or older.
This study uses Medicare data to estimate mortality differences for common medical conditions (pneumonia, heart failure, chronic obstructive pulmonary disease, urinary tract infection, others) at US critical access vs non–critical access hospitals between 2007 and 2017 with vs without adjustment for discharge diagnosis counts to assess the extent to which coding practices rather than illness severity might account for observed mortality differences.
This study uses Medicare’s Nursing Home Compare and a university long-term care database to compare census, admissions, discharges, and mortality at skilled nursing facilities (SNFs) in 3 metropolitan areas during March-May 2020 vs March-May 2019.
This study uses data from the National Center for Health Statistics to estimate excess deaths (ie, the difference between observed and expected deaths) in the US and the District of Columbia in the early weeks of the COVID-19 pandemic.
This study uses simulated patient phone calls to a random selection of US urgent care clinics (UCCs) to describe the proportion that offer membership programs with access to discounted visits for recurring fees and the characteristics (affiliations, accreditations, population income) and fees and charges of those that do.
In the context of the Black Lives Matter movement, this Viewpoint considers the demand that academic medicine address its own structural racism, and concludes on the basis of its history, culture, role, and influence that the institution can, should, and must make racial justice a part of its work and mission.
This Viewpoint discusses the mechanisms of the 5 leading COVID-19 vaccine candidates—2 messenger RNA vaccines, 1 recombinant VSV vector product, and 2 replication-defective adenovirus vector approaches—and emphasizes the need to demonstrate safety as well as efficacy to facilitate broad uptake by the public.
This Viewpoint lists 4 safeguards policy makers should consider before release of a COVID-19 vaccine, including ensuring effectiveness through clinical trials, providing evidence of safety, requiring informed consent before vaccination, and establishing comprehensive adverse effects monitoring systems.
This Viewpoint discusses physical and epidemiological evidence supporting droplet vs aerosol transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and concludes on balance that aerosol transmission seems unlikely to be the dominant mode of coronavirus disease 2019 (COVID-19) spread.
This Viewpoint uses the example of rapid changes to public reporting on the efficacy of hydroxychloroquine and remdesivir for COVID-19 to illustrate how misinformation damages the public’s trust in science and medicine, and urges accuracy and circumspection in news reports of developments in the pandemic.
This Viewpoint discusses how COVID-19–related policy decisions lead to trade-offs between medical, economic, social, and psychological outcomes, and emphasizes the need to account for deaths associated with unemployment and depression when estimating excess mortality.
This Viewpoint discusses halting progress in legislative and policy attempts to make access to high-quality mental health and substance use disorders service equal to that for medical-surgical services and prospects for further regulation of insurance to achieve the goal.
This Viewpoint discusses differences that complicate cross-country comparisons of health and social services and proposes a framework for assessing the appropriateness of those comparisons to help researchers improve their investigations and help readers critically appraise them.
In this narrative medicine essay, a urology fellow offers 5 actions the medical community should take to eliminate racial injustice and health disparities in the United States.
This narrative review summarizes the epidemiology, pathophysiology, diagnosis, management, and prognosis of heart failure with reduced ejection fraction.
This Medical Letter review describes how tafamidis prevents transthyretin protein complexes from disocciating into amyloid fibrils, and its recent approval in 2 different formulations (Vyndaqel and Vyndamax) for treatment of adults with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM).
This Medical News article is an interview with Chicago public health legend and retired physician Linda Rae Murray, MD, MPH, an adjunct assistant professor at the University of Illinois at Chicago School of Public Health and a past president of the American Public Health Association.
This JAMA Patient Page describes the possible benefits of convalescent plasma transfusion in the treatment of COVID-19 as well as plasma donation eligibility criteria.
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