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October 2020 - July 1883

Decade

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Issue

August 18, 2020, Vol 324, No. 7, Pages 617-718

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2020;324(7):e200033. doi:10.1001/jama.2020.0033
Original Investigation

Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial

Abstract Full Text
JAMA. 2020;324(7):642-650. doi:10.1001/jama.2020.11946

This randomized clinical trial compares the effect of combination hydrocortisone, ascorbic acid, and thiamine (the HAT or Marik protocol) vs placebo on SOFA score–measured organ injury at 72 hours in patients with septic shock.

Effect of a Collaborative Care Model on Depressive Symptoms and Glycated Hemoglobin, Blood Pressure, and Serum Cholesterol Among Patients With Depression and Diabetes in India: The INDEPENDENT Randomized Clinical Trial

Abstract Full Text
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JAMA. 2020;324(7):651-662. doi:10.1001/jama.2020.11747

This randomized clinical trial compares the effect of a collaborative care model that integrates management of depression and enhanced diabetes care on depressive symptoms and HbA1c, SBP, and LDL cholesterol measures among individuals with depression and diabetes in India.

Preliminary Communication

Presence of Genetic Variants Among Young Men With Severe COVID-19

Abstract Full Text
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JAMA. 2020;324(7):663-673. doi:10.1001/jama.2020.13719

This case series describes rare putative X-chromosomal loss-of-function variants associated with impaired peripheral mononuclear blood cell interferon signaling in 4 young male patients hospitalized with severe coronavirus disease 2019 (COVID-19) in the Netherlands.

Research Letter

Association Between Universal Masking in a Health Care System and SARS-CoV-2 Positivity Among Health Care Workers

Abstract Full Text
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JAMA. 2020;324(7):703-704. doi:10.1001/jama.2020.12897

This study describes SARS-CoV-2 PCR test positivity among health care workers before, during, and after implementation of a policy requiring universal masking of all health care workers and patients in a large health care system in Massachusetts.

Change in the Incidence of Stillbirth and Preterm Delivery During the COVID-19 Pandemic

Abstract Full Text
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JAMA. 2020;324(7):705-706. doi:10.1001/jama.2020.12746

This study compares pregnancy outcomes, including rates of stillbirth (fetal death ≥24 weeks’ gestation), preterm and cesarean delivery, and neonatal unit admission in the months preceding vs during the 2020 COVID-19 pandemic at a London university hospital.

Prevalence of Psychotropic and Opioid Prescription Fills Among Community-Dwelling Older Adults With Dementia in the US

Abstract Full Text
JAMA. 2020;324(7):706-708. doi:10.1001/jama.2020.8519

This pharmacoepidemiology study uses Medicare data to estimate US prescription fills for antidepressants, anxiolytics, antipsychotics, opioids, and antiepileptics among community-dwelling older adults with dementia in 2014-2015, and identifies the most commonly prescribed medications.

US Preventive Services Task Force

Recommendation Statement

Behavioral Counseling Interventions to Prevent Sexually Transmitted Infections: US Preventive Services Task Force Recommendation Statement

Abstract Full Text
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JAMA. 2020;324(7):674-681. doi:10.1001/jama.2020.13095

This 2020 US Preventive Services Task Force Recommendation Statement recommends behavioral counseling to prevent sexually transmitted infections (STIs) for all sexually active adolescents and for adults at increased risk for STIs (B recommendation).

Evidence Report

Behavioral Counseling Interventions to Prevent Sexually Transmitted Infections: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Abstract Full Text
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JAMA. 2020;324(7):682-699. doi:10.1001/jama.2020.10371

This systematic review to support the 2020 US Preventive Services Task Force Recommendation Statement on behavioral counseling interventions to prevent sexually transmitted infections (STIs) summarizes published evidence on the benefits and harms of behavioral counseling interventions in adolescents and adults at increased risk for the infections.

Viewpoint

COVID-19 and Dexamethasone: A Potential Strategy to Avoid Steroid-Related Strongyloides Hyperinfection

Abstract Full Text
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JAMA. 2020;324(7):623-624. doi:10.1001/jama.2020.13170

Anticipating widespread global use of dexamethasone for COVID-19 in the wake of RECOVERY trial findings, this Viewpoint summarizes the theoretical risk of triggering Strongyloides hyperinfection/dissemination syndrome in people with asymptomatic strongyloidiasis, and proposes an algorithm to for assessing and managing the risk in outpatient and hospital settings.

Weighing the Benefits and Risks of Proliferating Observational Treatment Assessments: Observational Cacophony, Randomized Harmony

Abstract Full Text
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JAMA. 2020;324(7):625-626. doi:10.1001/jama.2020.13319

This Viewpoint discusses the role of observational study designs and data in the rapid stand-up of an evidence base for managing the COVID-19 pandemic, proposing ways to position observational research as a foundation for rapid follow-on randomized evaluation without premature overinterpretation of its findings.

Exome Sequencing and Clinical Diagnosis

Abstract Full Text
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JAMA. 2020;324(7):627-628. doi:10.1001/jama.2020.11126

This Viewpoint describes indications and proper clinical use and interpretation of exome sequencing, explaining that the testing is not diagnostic in itself but requires correlation with patients’ history and presentation in the context of a comprehensive clinical evaluation.

Evidence-Based Practice for Public Health Emergency Preparedness and Response: Recommendations From a National Academies of Sciences, Engineering, and Medicine Report

Abstract Full Text
JAMA. 2020;324(7):629-630. doi:10.1001/jama.2020.12901

This Viewpoint summarizes recommendations from a 2020 National Academies of Sciences, Engineering, and Medicine (NASEM) report on transforming the infrastructure, funding, and methods of public health emergency preparedness and response (PHEPR) research to ensure it is grounded in the best science about what works where, why, and for whom.

Integrating Personalized Medicine With Population Health Management: The Path Forward

Abstract Full Text
JAMA. 2020;324(7):631-632. doi:10.1001/jama.2020.1406

This Viewpoint discusses genome-wide sequencing (GWS) as a potential pathway not only to personalized medicine but also to population health, and proposes 5 dimensions health care organizations might consider when deciding on markers to screen for as they move toward genomic approaches to caring for their patient populations.

A Piece of My Mind

Dressing Up

Abstract Full Text
JAMA. 2020;324(7):633-634. doi:10.1001/jama.2020.12779

In this narrative medicine essay, an emergency department physician faces her daily dread of donning PPE during the COVID-19 pandemic by recalling her grandfather’s gear when diving into Idaho mine shafts and compares his heroism fighting for miners’ rights to safety and wonders what he would think of calling health care workers on the frontlines heroes.

Editorial

Universal Masking to Prevent SARS-CoV-2 Transmission—The Time Is Now

Abstract Full Text
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JAMA. 2020;324(7):635-637. doi:10.1001/jama.2020.13107

Molecular Underpinnings of Severe Coronavirus Disease 2019

Abstract Full Text
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JAMA. 2020;324(7):638-639. doi:10.1001/jama.2020.14015

Behavioral Counseling for Sexually Transmitted Infection Risk Reduction

Abstract Full Text
JAMA. 2020;324(7):640-641. doi:10.1001/jama.2020.12324
JAMA Guide to Statistics and Methods

Using Latent Class Analysis to Identify Hidden Clinical Phenotypes

Abstract Full Text
JAMA. 2020;324(7):700-701. doi:10.1001/jama.2020.2278

This JAMA Guide to Statistics and Methods summarizes latent class analysis, a statistical technique that estimates the probability of patients belonging to a discrete group that shares specific combinations of observed variables, and explains how the technique is used and can be interpreted in observational research.

Medical News & Perspectives

Social Isolation—the Other COVID-19 Threat in Nursing Homes

Abstract Full Text
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JAMA. 2020;324(7):619-620. doi:10.1001/jama.2020.13484

This Medical News article discusses the mental and physical effects of infection-control lockdowns on nursing home residents during the novel coronavirus pandemic.

News From the Food and Drug Administration

Outpatient Treatment Option for Patients With Blood Cancer

Abstract Full Text
JAMA. 2020;324(7):622. doi:10.1001/jama.2020.14427

First Tobacco Product Receives “Reduced Exposure” Authorization

Abstract Full Text
JAMA. 2020;324(7):622. doi:10.1001/jama.2020.13907

A Plan to Use Modern Data Tools to Fight Foodborne Illness

Abstract Full Text
JAMA. 2020;324(7):622. doi:10.1001/jama.2020.14428
Global Health

Long-Acting PrEP Shows Promise

Abstract Full Text
JAMA. 2020;324(7):621. doi:10.1001/jama.2020.13412

Customized Injection Guidelines Reduce Nurses’ Errors

Abstract Full Text
JAMA. 2020;324(7):621. doi:10.1001/jama.2020.14432

Surge in Child Abuse, Harm During COVID-19 Pandemic Reported

Abstract Full Text
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JAMA. 2020;324(7):621. doi:10.1001/jama.2020.14433
Poetry and Medicine

To My Wasted Eggs

Abstract Full Text
JAMA. 2020;324(7):713. doi:10.1001/jama.2020.3687
JAMA Revisited

The Death of Huxley

Abstract Full Text
JAMA. 2020;324(7):714. doi:10.1001/jama.2019.13576

Professor Huxley

Abstract Full Text
JAMA. 2020;324(7):714. doi:10.1001/jama.2020.10959
JAMA Patient Page

Behavioral Counseling to Reduce Sexually Transmitted Infections

Abstract Full Text
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JAMA. 2020;324(7):718. doi:10.1001/jama.2020.12570

This JAMA Patient Page reviews the 2020 US Preventive Services Task Force’s recommendation in favor of behavioral counseling to reduce sexually transmitted infections (STIs) for all sexually active adolescents and for adults at increased risk of STIs (B recommendation).

Comment & Response

Uncemented vs Cemented Hemiarthroplasty for Hip Fracture

Abstract Full Text
JAMA. 2020;324(7):709-710. doi:10.1001/jama.2020.9061

Uncemented vs Cemented Hemiarthroplasty for Hip Fracture—Reply

Abstract Full Text
JAMA. 2020;324(7):710-711. doi:10.1001/jama.2020.9067

Physicians and Social Determinants of Health

Abstract Full Text
JAMA. 2020;324(7):711. doi:10.1001/jama.2020.9052

Physicians and Social Determinants of Health—Reply

Abstract Full Text
JAMA. 2020;324(7):711. doi:10.1001/jama.2020.9072
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2020;324(7):617-618. doi:10.1001/jama.2019.13569
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