This randomized clinical trial compares the effect of combination hydrocortisone, ascorbic acid, and thiamine (the HAT or Marik protocol) vs placebo on SOFA score–measured organ injury at 72 hours in patients with septic shock.
This randomized clinical trial compares the effect of a collaborative care model that integrates management of depression and enhanced diabetes care on depressive symptoms and HbA1c, SBP, and LDL cholesterol measures among individuals with depression and diabetes in India.
This case series describes rare putative X-chromosomal loss-of-function variants associated with impaired peripheral mononuclear blood cell interferon signaling in 4 young male patients hospitalized with severe coronavirus disease 2019 (COVID-19) in the Netherlands.
This study describes SARS-CoV-2 PCR test positivity among health care workers before, during, and after implementation of a policy requiring universal masking of all health care workers and patients in a large health care system in Massachusetts.
This study compares pregnancy outcomes, including rates of stillbirth (fetal death ≥24 weeks’ gestation), preterm and cesarean delivery, and neonatal unit admission in the months preceding vs during the 2020 COVID-19 pandemic at a London university hospital.
This pharmacoepidemiology study uses Medicare data to estimate US prescription fills for antidepressants, anxiolytics, antipsychotics, opioids, and antiepileptics among community-dwelling older adults with dementia in 2014-2015, and identifies the most commonly prescribed medications.
This 2020 US Preventive Services Task Force Recommendation Statement recommends behavioral counseling to prevent sexually transmitted infections (STIs) for all sexually active adolescents and for adults at increased risk for STIs (B recommendation).
This systematic review to support the 2020 US Preventive Services Task Force Recommendation Statement on behavioral counseling interventions to prevent sexually transmitted infections (STIs) summarizes published evidence on the benefits and harms of behavioral counseling interventions in adolescents and adults at increased risk for the infections.
Anticipating widespread global use of dexamethasone for COVID-19 in the wake of RECOVERY trial findings, this Viewpoint summarizes the theoretical risk of triggering Strongyloides hyperinfection/dissemination syndrome in people with asymptomatic strongyloidiasis, and proposes an algorithm to for assessing and managing the risk in outpatient and hospital settings.
This Viewpoint discusses the role of observational study designs and data in the rapid stand-up of an evidence base for managing the COVID-19 pandemic, proposing ways to position observational research as a foundation for rapid follow-on randomized evaluation without premature overinterpretation of its findings.
This Viewpoint describes indications and proper clinical use and interpretation of exome sequencing, explaining that the testing is not diagnostic in itself but requires correlation with patients’ history and presentation in the context of a comprehensive clinical evaluation.
This Viewpoint summarizes recommendations from a 2020 National Academies of Sciences, Engineering, and Medicine (NASEM) report on transforming the infrastructure, funding, and methods of public health emergency preparedness and response (PHEPR) research to ensure it is grounded in the best science about what works where, why, and for whom.
This Viewpoint discusses genome-wide sequencing (GWS) as a potential pathway not only to personalized medicine but also to population health, and proposes 5 dimensions health care organizations might consider when deciding on markers to screen for as they move toward genomic approaches to caring for their patient populations.
In this narrative medicine essay, an emergency department physician faces her daily dread of donning PPE during the COVID-19 pandemic by recalling her grandfather’s gear when diving into Idaho mine shafts and compares his heroism fighting for miners’ rights to safety and wonders what he would think of calling health care workers on the frontlines heroes.
This JAMA Guide to Statistics and Methods summarizes latent class analysis, a statistical technique that estimates the probability of patients belonging to a discrete group that shares specific combinations of observed variables, and explains how the technique is used and can be interpreted in observational research.
This Medical News article discusses the mental and physical effects of infection-control lockdowns on nursing home residents during the novel coronavirus pandemic.
This JAMA Patient Page reviews the 2020 US Preventive Services Task Force’s recommendation in favor of behavioral counseling to reduce sexually transmitted infections (STIs) for all sexually active adolescents and for adults at increased risk of STIs (B recommendation).
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