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March 2023 - July 1883




August 25, 2020, Vol 324, No. 8, Pages 725-816

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2020;324(8):e200034. doi:10.1001/jama.2020.0034
Original Investigation

Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial

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JAMA. 2020;324(8):752-760. doi:10.1001/jama.2020.12384

This randomized trial compares the effects of vitamin D3 vs placebo on time to severe exacerbation in children with asthma and low vitamin D levels.

Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy on Ischemic Outcomes After Percutaneous Coronary Intervention: The TAILOR-PCI Randomized Clinical Trial

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JAMA. 2020;324(8):761-771. doi:10.1001/jama.2020.12443

This open-label randomized trial compares the effect of a genotype-guided oral P2Y12 inhibitor selection strategy vs conventional clopidogrel prescribing on 12-month ischemic outcomes after percutaneous coronary intervention (PCI) in CYP2C19*2/CYP2C19*3 loss-of-function allele carriers with acute coronary syndromes and stable cardiovascular disease.

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

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JAMA. 2020;324(8):772-781. doi:10.1001/jama.2020.12134

This cross-sectional study compares the accuracy of plasma tau phosphorylated at threonine 217 (P-tau217) levels vs other plasma-, MRI-, CSF-, and PET-based markers for distinguishing Alzheimer from other neurodegenerative diseases in 3 cohorts in Arizona, Sweden, and Columbia with or at risk for dementia.

Research Letter

Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System

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JAMA. 2020;324(8):799-801. doi:10.1001/jama.2020.13372

This study examines the incidence of and risk factors for venous and arterial thrombosis in patients hospitalized with COVID-19 in 4 New York City hospitals.

Ketoacidosis in Children and Adolescents With Newly Diagnosed Type 1 Diabetes During the COVID-19 Pandemic in Germany

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JAMA. 2020;324(8):801-804. doi:10.1001/jama.2020.13445

This study uses diabetes registry data to compare the frequency of diabetic ketoacidosis (DKA) in children and adolescents at time of type 1 diabetes diagnosis in Germany during the first 2 months of the coronavirus disease 2019 (COVID-19) pandemic vs the same time period in 2018 and 2019.

Therapies Offered at Residential Addiction Treatment Programs in the United States

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JAMA. 2020;324(8):804-806. doi:10.1001/jama.2020.8969

This study uses simulated patient calls to a random sample of US residential addiction treatment facilities to investigate the availability of opioid agonist treatment (buprenorphine-naloxone) and nonpharmacologic therapies (eg, CBT) for opioid use disorder, and differences by for-profit vs nonprofit center status.


Precision Nutrition—the Answer to “What to Eat to Stay Healthy”

Abstract Full Text
JAMA. 2020;324(8):735-736. doi:10.1001/jama.2020.13601

In this Viewpoint directors of the NIH and NIDDK summarize the agency’s 2020-2030 Strategic Plan for NIH Nutrition Research, a roadmap to establish a science of nutrition as a means to prevent and treat illness and to develop actionable, evidence-based dietary recommendations across cultures and settings.

Black Kidney Function Matters: Use or Misuse of Race?

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JAMA. 2020;324(8):737-738. doi:10.1001/jama.2020.13378

This Viewpoint discusses the practice of using patient race as a variable in algorithms to determine kidney function and suggests that estimating tools be developed that are equally precise but exclude race as a factor.

Recovery From Severe COVID-19: Leveraging the Lessons of Survival From Sepsis

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JAMA. 2020;324(8):739-740. doi:10.1001/jama.2020.14103

This Viewpoint discusses the possibility that survivors of severe COVID-19 will experience persistent symptoms similar to those of post-sepsis syndrome and reviews best practices for promoting recovery from intensive care illness, including referral to physical and occupational therapy, medication optimization, and structured exercise.

Attacks on Public Health Officials During COVID-19

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JAMA. 2020;324(8):741-742. doi:10.1001/jama.2020.14423

This Viewpoint discusses ongoing harassment and threats against US public health officials who propose or take steps to protect communities from coronavirus disease 2019 (COVID-19) and it proposes possible responses, including a call to elected leaders to implement protection of the officials from illegal harassment, assault, and violence.

COVID-19 in Canada: Experience and Response

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JAMA. 2020;324(8):743-744. doi:10.1001/jama.2020.14033

This Viewpoint summarizes federal, provincial, and regional responses to the COVID-19 pandemic in Canada and explores reasons for differences in pandemic outcomes in Canada and the US.

A Piece of My Mind

Growing Pains

Abstract Full Text
JAMA. 2020;324(8):745-746. doi:10.1001/jama.2020.13442

In this narrative medicine essay, a medical student describes her experience growing up with a leg prosthesis and requiring orthopedic procedures to maintain her limb growth and describes reactions to her disability from uncomprehending peers and mentors in her medical training.


CYP2C19 Genotyping to Guide Antiplatelet Therapy After Percutaneous Coronary Interventions: One Size Rarely Fits All

Abstract Full Text
JAMA. 2020;324(8):747-749. doi:10.1001/jama.2020.13094

Serosurveillance and the COVID-19 Epidemic in the US: Undetected, Uncertain, and Out of Control

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JAMA. 2020;324(8):749-751. doi:10.1001/jama.2020.14017

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review

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JAMA. 2020;324(8):782-793. doi:10.1001/jama.2020.12839

This narrative review discusses what is currently known about the pathophysiology, epidemiology, diagnosis, management, prognosis, and prevention of coronavirus disease 2019 (COVID-19).

JAMA Insights

Current Perspective on Age-Related Macular Degeneration

Abstract Full Text
JAMA. 2020;324(8):794-795. doi:10.1001/jama.2020.5576

This JAMA Insights Clinical Update reviews the epidemiology, clinical manifestations, classification, diagnosis, prevention, and approved and investigational treatment of age-related macular degeneration in older adults.

JAMA Diagnostic Test Interpretation

Postexercise Ankle-Brachial Index Testing

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JAMA. 2020;324(8):796-797. doi:10.1001/jama.2020.10164

A 61-year-old woman with a history of hypertension presented for evaluation of exertional left calf discomfort. Her lower extremity systolic blood pressure and ankle-brachial index (ABI) measures declined after treadmill testing. What would you do next?

Medical News & Perspectives

From Auto Mechanic to Emergency Medicine Resident: Inspiring Young Blacks to Become Physicians

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JAMA. 2020;324(8):727-729. doi:10.1001/jama.2020.14306

This Medical News article discusses the circuitous path Carl Allamby, MD, traveled from auto repair shop owner to emergency medicine resident.

JAMA Live Highlights

Experts Discuss COVID-19—Remdesivir, Vaccines, and More

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JAMA. 2020;324(8):730-731. doi:10.1001/jama.2020.15067

This JAMA Live Highlights feature provides comments about the coronavirus 2019 pandemic from experts in clinical medicine, public health, and health policy expressed during livestream interviews with JAMA Network Editor in Chief Howard Bauchner, MD.

News From the Centers for Disease Control and Prevention

Football-Related Head Injuries Decline Among Children and Teens

Abstract Full Text
JAMA. 2020;324(8):734. doi:10.1001/jama.2020.14163

Lung Diseases Affecting US Workers Cost Billions Annually

Abstract Full Text
JAMA. 2020;324(8):734. doi:10.1001/jama.2020.14764
Clinical Trials Update

Elagolix Reduces Fibroid-Related Heavy Menstrual Bleeding Long-term

Abstract Full Text
JAMA. 2020;324(8):733. doi:10.1001/jama.2020.13960

Aspirin Fails to Prevent Depression in Older Adults

Abstract Full Text
JAMA. 2020;324(8):733. doi:10.1001/jama.2020.14802

Shorter Resident Shifts May Not Improve Patient Safety

Abstract Full Text
JAMA. 2020;324(8):733. doi:10.1001/jama.2020.14803

Mailings, Phone Calls Increase Post-MI Cardiac Rehabilitation

Abstract Full Text
JAMA. 2020;324(8):733. doi:10.1001/jama.2020.14805

Aspirin Protects Against Colorectal Cancer in Lynch Syndrome

Abstract Full Text
JAMA. 2020;324(8):733. doi:10.1001/jama.2020.14804
Health Agencies Update

Household Composition May Explain COVID-19 Racial/Ethnic Disparities

Abstract Full Text
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JAMA. 2020;324(8):732. doi:10.1001/jama.2020.14375

Difficult to Determine Herd Immunity Threshold for COVID-19

Abstract Full Text
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JAMA. 2020;324(8):732. doi:10.1001/jama.2020.14778

Streetlights May Keep Teens Up at Night, Affecting Mental Health

Abstract Full Text
JAMA. 2020;324(8):732. doi:10.1001/jama.2020.14785
Poetry and Medicine

A Song Sung Sweet to Greet the Dead

Abstract Full Text
JAMA. 2020;324(8):810. doi:10.1001/jama.2020.6795
JAMA Revisited

Renaudot and the First French Newspaper and Medical Journal

Abstract Full Text
JAMA. 2020;324(8):811. doi:10.1001/jama.2019.13587
JAMA Patient Page

What Is LASIK Eye Surgery?

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JAMA. 2020;324(8):815. doi:10.1001/jama.2020.1286

This JAMA Patient Page describes LASIK, a type of laser surgery that corrects blurry vision usually treated with eyeglasses, and summarizes who can benefit and the procedure’s risks.

What Is COVID-19?

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JAMA. 2020;324(8):816. doi:10.1001/jama.2020.12984

This JAMA Patient Page provides an overview of COVID-19 transmission, symptoms, diagnosis, disease course, and treatment.

Comment & Response

Reducing Intraoperative Hypotension Using a Machine Learning–Derived Early Warning System

Abstract Full Text
JAMA. 2020;324(8):806-807. doi:10.1001/jama.2020.9049

Reducing Intraoperative Hypotension Using a Machine Learning–Derived Early Warning System—Reply

Abstract Full Text
JAMA. 2020;324(8):807-808. doi:10.1001/jama.2020.9064

Drug Shortages and Group Purchasing Organizations

Abstract Full Text
JAMA. 2020;324(8):808-809. doi:10.1001/jama.2020.9055

Drug Shortages and Group Purchasing Organizations—Reply

Abstract Full Text
JAMA. 2020;324(8):809. doi:10.1001/jama.2020.9058
JAMA Masthead


Abstract Full Text
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JAMA. 2020;324(8):725-726. doi:10.1001/jama.2019.13580