This randomized trial compares the effects of vitamin D3 vs placebo on time to severe exacerbation in children with asthma and low vitamin D levels.
This open-label randomized trial compares the effect of a genotype-guided oral P2Y12 inhibitor selection strategy vs conventional clopidogrel prescribing on 12-month ischemic outcomes after percutaneous coronary intervention (PCI) in CYP2C19*2/CYP2C19*3 loss-of-function allele carriers with acute coronary syndromes and stable cardiovascular disease.
This cross-sectional study compares the accuracy of plasma tau phosphorylated at threonine 217 (P-tau217) levels vs other plasma-, MRI-, CSF-, and PET-based markers for distinguishing Alzheimer from other neurodegenerative diseases in 3 cohorts in Arizona, Sweden, and Columbia with or at risk for dementia.
This study examines the incidence of and risk factors for venous and arterial thrombosis in patients hospitalized with COVID-19 in 4 New York City hospitals.
This study uses diabetes registry data to compare the frequency of diabetic ketoacidosis (DKA) in children and adolescents at time of type 1 diabetes diagnosis in Germany during the first 2 months of the coronavirus disease 2019 (COVID-19) pandemic vs the same time period in 2018 and 2019.
This study uses simulated patient calls to a random sample of US residential addiction treatment facilities to investigate the availability of opioid agonist treatment (buprenorphine-naloxone) and nonpharmacologic therapies (eg, CBT) for opioid use disorder, and differences by for-profit vs nonprofit center status.
In this Viewpoint directors of the NIH and NIDDK summarize the agency’s 2020-2030 Strategic Plan for NIH Nutrition Research, a roadmap to establish a science of nutrition as a means to prevent and treat illness and to develop actionable, evidence-based dietary recommendations across cultures and settings.
This Viewpoint discusses the practice of using patient race as a variable in algorithms to determine kidney function and suggests that estimating tools be developed that are equally precise but exclude race as a factor.
This Viewpoint discusses the possibility that survivors of severe COVID-19 will experience persistent symptoms similar to those of post-sepsis syndrome and reviews best practices for promoting recovery from intensive care illness, including referral to physical and occupational therapy, medication optimization, and structured exercise.
This Viewpoint discusses ongoing harassment and threats against US public health officials who propose or take steps to protect communities from coronavirus disease 2019 (COVID-19) and it proposes possible responses, including a call to elected leaders to implement protection of the officials from illegal harassment, assault, and violence.
This Viewpoint summarizes federal, provincial, and regional responses to the COVID-19 pandemic in Canada and explores reasons for differences in pandemic outcomes in Canada and the US.
In this narrative medicine essay, a medical student describes her experience growing up with a leg prosthesis and requiring orthopedic procedures to maintain her limb growth and describes reactions to her disability from uncomprehending peers and mentors in her medical training.
This narrative review discusses what is currently known about the pathophysiology, epidemiology, diagnosis, management, prognosis, and prevention of coronavirus disease 2019 (COVID-19).
This JAMA Insights Clinical Update reviews the epidemiology, clinical manifestations, classification, diagnosis, prevention, and approved and investigational treatment of age-related macular degeneration in older adults.
A 61-year-old woman with a history of hypertension presented for evaluation of exertional left calf discomfort. Her lower extremity systolic blood pressure and ankle-brachial index (ABI) measures declined after treadmill testing. What would you do next?
This Medical News article discusses the circuitous path Carl Allamby, MD, traveled from auto repair shop owner to emergency medicine resident.
This JAMA Live Highlights feature provides comments about the coronavirus 2019 pandemic from experts in clinical medicine, public health, and health policy expressed during livestream interviews with JAMA Network Editor in Chief Howard Bauchner, MD.
This JAMA Patient Page describes LASIK, a type of laser surgery that corrects blurry vision usually treated with eyeglasses, and summarizes who can benefit and the procedure’s risks.
This JAMA Patient Page provides an overview of COVID-19 transmission, symptoms, diagnosis, disease course, and treatment.
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