This randomized clinical trial compares the effect of intraoperative ventilation with low vs conventional tidal volume (6 vs 10 mL/kg predicted body weight) on pulmonary complications in the first 7 postoperative days among patients undergoing major surgery lasting longer than 2 hours.
This population epidemiology study estimates associations of school closures in the US and the timing of those closures in March 2020 with change in daily coronavirus disease 2019 (COVID-19) incidence and mortality through the first week of May, accounting for other contemporaneous public health interventions.
This retrospective study compared the rate of ischemic stroke or transient ischemic attack among Olmstead County, Minnesota, residents with vs without new-onset postoperative atrial fibrillation after undergoing noncardiac surgery.
This seroprevalence survey study describes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity among health care workers at a New York City–based health system by age, sex, race, county of residence, and prior PCR-confirmed viral exposure.
This pharmacoepidemiology study uses Scandinavian birth registry data to estimate the association between modafinil use during early pregnancy and major congenital malformations among infants born in Norway and Sweden between 2005-2006 and 2016-2017.
This Viewpoint summarizes recommendations made in a National Academies of Sciences, Engineering, and Medicine report about how to safely reopen and operate elementary and secondary schools for the 2020-2021 school year, which emphasizes the need for partnerships with public health officials and community leaders, and for transparent communication of risks and rewards that will result from every policy decision.
This Viewpoint describes how the COVID-19 pandemic has made more obvious the work-life imbalance inherent in the practice of medicine and how the moment offers the profession the chance to recalibrate gender role stereotypes that have traditionally disadvantaged the careers of women physicians and researchers.
This Viewpoint proposes legal and policy options for promoting universal face mask wearing in the US and, recognizing the limits of state-by-state implementation, proposes strengthening the authority, independence, and funding of the CDC to enact responses to this and future comparable public health emergencies.
This Viewpoint uses US News & World Report’s annual hospital rankings to discuss how such efforts typically disadvantage hospitals caring for patients of lower socioeconomic status (SES) in regions with poorer population health, and argues for transparent and accurate ratings methods that use patient-centric quality measures and account for population SES.
This Viewpoint attributes improved understanding of the role of autoantibodies and B-cell activity in MS pathogenesis and the development of effective therapies to the ability of physician-scientists to bring clinical insights to laboratory research and it emphasizes the importance of supporting and encouraging these investigators to reinvigorate science at the bedside.
In this narrative medicine essay a father recalls the traumatic death of his healthy young son and the steps he and his family took to overcome their guilt, repair their relationships, and honor the boy’s life.
Precis This narrative review summarizes the efficacy and safety of bariatric surgery, mainly sleeve gastrectomy and the Roux-en-Y procedure, in assisting weight loss and in patients with type 2 diabetes and other obesity-related comorbidities.
This JAMA Insights Clinical Update reviews long-term complications of bariatric surgery, including GERD, gallstones, hypoglycemia, substance use disorder, and vitamin and other nutritional deficiencies, and proposes a schedule of testing and management strategies for each.
This Medical Letter review summarizes evidence supporting the use of rimegepant (Nurtec), a small-molecule calcitonin gene-related peptide receptor antagonist, for acute treatment of migraine with or without aura in adults.
This Medical News article discusses efforts to ensure participation of racial and ethnic minorities in clinical trials of COVID-19 vaccines.
This JAMA Patient Page explains who should undergo gastric sleeve procedure, a type of obesity surgery; how to prepare for it; and what to expect afterward.