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May 2022 - July 1883

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March 16, 2021, Vol 325, No. 11, Pages 1025-1118

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;325(11):e2017845. doi:10.1001/jama.2020.17845
Original Investigation

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(11):1053-1060. doi:10.1001/jama.2020.26848

This randomized trial compares the effects of a single 200 000-IU dose of vitamin D3 vs placebo on length of stay in patients hospitalized with moderate to severe COVID-19.

Effect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on Incident Atrial Fibrillation: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(11):1061-1073. doi:10.1001/jama.2021.1489

This 2 × 2 factorial trial compares the effects of omega-3 fatty acids (460 mg/d of EPA and 380 mg/d of DHA) vs placebo, vitamin D₃ vs placebo, both, or neither on risk of incident atrial fibrillation (AF) among adults aged 50 years or older over a median of more than 5 years of treatment.

Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19

Abstract Full Text
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JAMA. 2021;325(11):1074-1087. doi:10.1001/jama.2021.2091

This case series uses national coronavirus disease 2019 (COVID-19) registry data to describe the epidemiology, clinical characteristics, complications, and hospital and postdischarge outcomes of pediatric patients with multisystem inflammatory syndrome in children (MIS-C) and to compare each in patients with severe COVID-19.

Research Letter

Telehealth Use Among Safety-Net Organizations in California During the COVID-19 Pandemic

Abstract Full Text
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JAMA. 2021;325(11):1106-1107. doi:10.1001/jama.2021.0282

This study describes trends in use of in-person, telephone, and video primary care and behavioral health visits to California Federally Qualified Health Centers from 2019 to August 2020 before and during the coronavirus disease 2019 (COVID-19) pandemic.

Alcohol-Related Deaths in Poland During a Period of Weakening Alcohol Control Measures

Abstract Full Text
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JAMA. 2021;325(11):1108-1109. doi:10.1001/jama.2020.25879

This population epidemiology study describes trends in overall and age- and sex-specific alcohol-related deaths in Poland between 2002 and 2017, following the weakening in 2001 of policy measures designed to reduce alchohol consumption.

Viewpoint

Health Policy

Improving Health Among Rural Residents in the US

Abstract Full Text
JAMA. 2021;325(11):1033-1034. doi:10.1001/jama.2020.26372

This Viewpoint summarizes health care challenges faced by US rural residents and suggests how administrative strategies, such as ensuring rural representation in policy development and implementation, and legislative strategies, such as ensuring rural broadband access, could help achieve health equity for residents in rural areas.

Health Policy

Improving the Health of the American Indian and Alaska Native Population

Abstract Full Text
JAMA. 2021;325(11):1035-1036. doi:10.1001/jama.2021.0521

This Viewpoint reviews evidence of poor health outcomes experienced by American Indian/Alaska Native persons owing to structural disadvantage and proposes an aggressive agenda to improve their health and well-being by addressing social determinants of health, improving access to and quality of care, and improving data availability and transparency.

SARS-CoV-2 Variants of Concern in the United States—Challenges and Opportunities

Abstract Full Text
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JAMA. 2021;325(11):1037-1038. doi:10.1001/jama.2021.2294

This Viewpoint from directors at the CDC and NIH describes measures that federal agencies are taking to rapidly characterize emerging coronavirus variants and monitor their implications for national pandemic response and control, including assessment of ongoing effectiveness of current diagnostics, therapeutics, and vaccines.

COVID-19 Vaccination in Pregnant and Lactating Women

Abstract Full Text
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JAMA. 2021;325(11):1039-1040. doi:10.1001/jama.2021.1658

This Viewpoint discusses the need for shared decision-making when counseling pregnant and nursing women about the unstudied benefits and risks COVID-19 vaccination, calling for rigorously designed studies with real-time, proactive data collection to establish evidence as quickly as possible about coronavirus vaccine safety in mothers and their infants.

Involving Pregnant Individuals in Clinical Research on COVID-19 Vaccines

Abstract Full Text
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JAMA. 2021;325(11):1041-1042. doi:10.1001/jama.2021.1865

This Viewpoint from the National Institute of Child Health and Human Development emphasizes the need to use existing data sources and develop partnerships, infrastructure, and ethical and regulatory standards to generate data about the safety and efficacy of COVID-19 vaccination in pregnant individuals.

Scientific Discovery and the Future of Medicine

New Insights Into Plaque Erosion as a Mechanism of Acute Coronary Syndromes

Abstract Full Text
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JAMA. 2021;325(11):1043-1044. doi:10.1001/jama.2021.0069

This Viewpoint summarizes the pathophysiology and clinical features of atherosclerotic plaque erosion as an underlying mechanism of acute coronary syndromes (ACS) distinct from plaque rupture and reviews evidence that antithrombotic therapy without PCI and stenting may be optimal treatment.

A Piece of My Mind

Somebody’s Sunshine

Abstract Full Text
JAMA. 2021;325(11):1045-1046. doi:10.1001/jama.2021.1549

In this narrative medicine essay a geriatrics fellow describes the experience of preparing for and meeting her foster son and discusses her feelings of uncertainties that (mostly) melt away when sharing her new child's photo with a colleague the day after bringing him home.

Editorial

Vitamin D3 to Treat COVID-19: Different Disease, Same Answer

Abstract Full Text
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JAMA. 2021;325(11):1047-1048. doi:10.1001/jama.2020.26850

The Reporting of Race and Ethnicity in Medical and Science Journals: Comments Invited

Abstract Full Text
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JAMA. 2021;325(11):1049-1052. doi:10.1001/jama.2021.2104
Review

Diagnosis and Management of Transient Ischemic Attack and Acute Ischemic Stroke: A Review

Abstract Full Text
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JAMA. 2021;325(11):1088-1098. doi:10.1001/jama.2020.26867

This narrative review provides an update on management of transient ischemic attack (TIA) and acute ischemic stroke, emphasizing advances in use of dual antiplatelet therapy and fibrinolysis vs mechanical thrombectomy for secondary and tertiary prevention.

JAMA Insights

Women's Health

Pregnancy, Postpartum Care, and COVID-19 Vaccination in 2021

Abstract Full Text
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JAMA. 2021;325(11):1099-1100. doi:10.1001/jama.2021.1683

This JAMA Insights review summarizes the epidemiology of SARS-CoV-2 infection in pregnant and lactating women, its effects on perinatal outcomes, and compiles guidance from the CDC, FDA, and obstetrics-gynecology specialty organizations on the safety of coronavirus vaccines during pregnancy and while breastfeeding.

Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021

Abstract Full Text
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JAMA. 2021;325(11):1101-1102. doi:10.1001/jama.2021.1967

This JAMA Insights review provides clinical details of anaphylactic reactions reported to and verified by the CDC in the first month of use of the Pfizer-BioNTech and Moderna COVID-19 vaccines in the US, December 14, 2020-January 18, 2021.

JAMA Clinical Challenge

Pruritic Rash and Diarrhea

Abstract Full Text
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JAMA. 2021;325(11):1103-1104. doi:10.1001/jama.2020.24066

An 82-year-old woman reported 2 months of diarrhea and 2 weeks of pruritic rash on her extremities as well as a recent left radius fracture; she was malnourished but most laboratory parameters were normal except mild hyponatremia and levels of copper and zinc well below normal. What is the diagnosis and what would you do next?

Editor's Note

Omega-3 Fatty Acids and Atrial Fibrillation

Abstract Full Text
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JAMA. 2021;325(11):1063. doi:10.1001/jama.2021.2909
Medical News & Perspectives

Quick Uptakes

Pregnant People’s Paradox—Excluded From Vaccine Trials Despite Having a Higher Risk of COVID-19 Complications

Abstract Full Text
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JAMA. 2021;325(11):1027-1028. doi:10.1001/jama.2021.2264

This Medical News Quick Uptake discusses the evidence in favor of administering COVID-19 vaccines to pregnant individuals.

News From the Food and Drug Administration

CAR-T Therapy Is Approved for Non-Hodgkin Lymphoma

Abstract Full Text
JAMA. 2021;325(11):1032. doi:10.1001/jama.2021.3004

Device Uses Electrical Stimulation to Control Snoring

Abstract Full Text
JAMA. 2021;325(11):1032. doi:10.1001/jama.2021.2622

Helping Manufacturers Navigate Novel Coronavirus Variants

Abstract Full Text
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JAMA. 2021;325(11):1032. doi:10.1001/jama.2021.3006
The JAMA Forum

2020 Revealed How Poorly the US Was Prepared for COVID-19—and Future Pandemics

Abstract Full Text
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JAMA. 2021;325(11):1029-1030. doi:10.1001/jama.2021.1046
Global Health

Saving Tens of Thousands of Lives by Cutting Air Pollution

Abstract Full Text
JAMA. 2021;325(11):1031. doi:10.1001/jama.2021.2292

Most Patients Hospitalized With COVID-19 Have Lasting Symptoms

Abstract Full Text
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JAMA. 2021;325(11):1031. doi:10.1001/jama.2021.2974

New WHO Guideline for Treating Chronic Pain in Children

Abstract Full Text
JAMA. 2021;325(11):1031. doi:10.1001/jama.2021.2976
Poetry and Medicine

A Fib

Abstract Full Text
JAMA. 2021;325(11):1114. doi:10.1001/jama.2020.25268
JAMA Revisited

The Achievement of the Army Medical Department in the World War

Abstract Full Text
JAMA. 2021;325(11):1115. doi:10.1001/jama.2020.17846
JAMA Patient Page

Spontaneous Bacterial Peritonitis

Abstract Full Text
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JAMA. 2021;325(11):1118. doi:10.1001/jama.2020.10292

This JAMA Patient Page explains the causes, symptoms, diagnosis, and treatment of spontaneous bacterial peritonitis, an infection of fluid (ascites) that accumulates in the abdomen in liver disease and other conditions.

Comment & Response

Algorithm to Evaluate Abnormal Liver Function Tests in Liver Transplant Patients

Abstract Full Text
JAMA. 2021;325(11):1109-1110. doi:10.1001/jama.2021.0162

Algorithm to Evaluate Abnormal Liver Function Tests in Liver Transplant Patients—Reply

Abstract Full Text
JAMA. 2021;325(11):1110. doi:10.1001/jama.2021.0165

Evaluation of a Strength-Training Program on Clinical Outcomes in Older Adults

Abstract Full Text
JAMA. 2021;325(11):1110-1111. doi:10.1001/jama.2021.0337

Evaluation of a Strength-Training Program on Clinical Outcomes in Older Adults

Abstract Full Text
JAMA. 2021;325(11):1111. doi:10.1001/jama.2021.0298

Evaluation of a Strength-Training Program on Clinical Outcomes in Older Adults

Abstract Full Text
JAMA. 2021;325(11):1111-1112. doi:10.1001/jama.2021.0301

Evaluation of a Strength-Training Program on Clinical Outcomes in Older Adults—Reply

Abstract Full Text
JAMA. 2021;325(11):1112-1113. doi:10.1001/jama.2021.0304
Correction

Transposed Data in a Table

Abstract Full Text
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JAMA. 2021;325(11):1113. doi:10.1001/jama.2021.2248

Incorrect Unit of Measure

Abstract Full Text
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JAMA. 2021;325(11):1113. doi:10.1001/jama.2021.2336
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2021;325(11):1025-1026. doi:10.1001/jama.2020.17843
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