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September 2023 - July 1883




June 1, 2021, Vol 325, No. 21, Pages 2133-2218

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;325(21):e2017965. doi:10.1001/jama.2020.17965
Original Investigation

Effect of Implantable vs Prolonged External Electrocardiographic Monitoring on Atrial Fibrillation Detection in Patients With Ischemic Stroke: The PER DIEM Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(21):2160-2168. doi:10.1001/jama.2021.6128

This randomized clinical trial compares 12 months of implantable loop recorder monitoring to detect atrial fibrillation vs conventional external loop recorder monitoring for 30 days in patients with a recent ischemic stroke.

Effect of Long-term Continuous Cardiac Monitoring vs Usual Care on Detection of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease: The STROKE-AF Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(21):2169-2177. doi:10.1001/jama.2021.6470

This randomized clinical trial examines whether long-term cardiac monitoring with an insertable cardiac monitor was more effective than usual care for detection of atrial fibrillation in patients with stroke attributed to cervical or intracranial large artery atherosclerosis or small-vessel occlusion (large- or small-vessel disease).

Effect of Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab on Remission Induction in ANCA-Associated Vasculitis: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(21):2178-2187. doi:10.1001/jama.2021.6615

This randomized trial compares the effect of a reduced-dose glucocorticoid plus rituximab regimen vs the standard high-dose glucocorticoid plus rituximab regimen on remission induction of antineutrophil cytoplasm antibody (ANCA)–associated vasculitis.

Research Letter

Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients

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JAMA. 2021;325(21):2204-2206. doi:10.1001/jama.2021.7489

This follow-up study measures the antibody response following the second dose of SARS-CoV-2 mRNA vaccine in recipients of solid organ transplants.

Concentration of Patient Care Among Buprenorphine-Prescribing Clinicians in the US

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JAMA. 2021;325(21):2206-2208. doi:10.1001/jama.2021.4469

This study quantifies the total amount of buprenorphine care delivered by active prescribers and to what extent that varies across specialties.


Reconceptualizing How to Support Surrogates Making Medical Decisions for Critically Ill Patients

Abstract Full Text
JAMA. 2021;325(21):2147-2148. doi:10.1001/jama.2021.6445

This Viewpoint discusses ways clinicians can provide emotional and psychological support to surrogate decision makers to provide individualized support, lessen their strain, and foster patient-centered decisions for patients unable to make their own.

Implementing Measurement Science for Electronic Health Record Use

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JAMA. 2021;325(21):2149-2150. doi:10.1001/jama.2021.5487

This Viewpoint considers the barriers to efficient medical record keeping and suggests ways the systems can be studied to maximize their promise and minimize the undue burden many physicians shoulder.

An Evolving Hospital Quality Star Rating System From CMS: Aligning the Stars

Abstract Full Text
JAMA. 2021;325(21):2151-2152. doi:10.1001/jama.2021.6946

This Viewpoint discusses updates to the Hospital Quality Star Ratings issued by the Centers for Medicare & Medicaid Services (CMS), including changes designed to make the rating system simpler and to make comparisons of hospitals more meaningful as well as some continuing challenges.

Does Sleep Flush Wastes From the Brain?

Abstract Full Text
JAMA. 2021;325(21):2153-2155. doi:10.1001/jama.2021.5631

This Viewpoint explains emerging science that suggests sleep activates the meningeal lymphatic and glymphatic systems to flush fluid and waste products out of the brain and discusses associations between disrupted sleep and neurological disease that may be mediated by glymphatic dysfunction.

A Piece of My Mind

The Challenge of Knowing

Abstract Full Text
JAMA. 2021;325(21):2155-2156. doi:10.1001/jama.2021.7850

In this narrative medicine essay, a geriatrician and palliative care physician learns what it's like to be a patient’s family member during her father’s last days, what it’s like to know the outcome before being told, and what it’s like to wait until after doing everything possible medically to give him permission to let go.


Detection of Subclinical Atrial Fibrillation After Stroke: Is There Enough Evidence to Treat?

Abstract Full Text
JAMA. 2021;325(21):2157-2159. doi:10.1001/jama.2021.7429

Lower Extremity Peripheral Artery Disease Without Chronic Limb-Threatening Ischemia: A Review

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JAMA. 2021;325(21):2188-2198. doi:10.1001/jama.2021.2126

This narrative review provides an update on the management of lower extremity peripheral artery disease (PAD), including treatment with the highest dose of statin tolerated, antithrombotic and/or antiplatelet therapy, and exercise.

JAMA Insights

Mask Mandates, On-Premises Dining, and COVID-19

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JAMA. 2021;325(21):2199-2200. doi:10.1001/jama.2021.5455

This JAMA Insights Clinical Update from the CDC’s COVID-19 Response Team discusses the association of changes in COVID-19 case rates and death rates with implementation of state-issued mask mandates and allowance of any on-premises restaurant dining.

Reactogenicity Following Receipt of mRNA-Based COVID-19 Vaccines

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JAMA. 2021;325(21):2201-2202. doi:10.1001/jama.2021.5374

This JAMA Insights Clinical Update summarizes adverse reactions to the Pfizer-BioNTech and Moderna mRNA-based COVID-19 vaccines reported through February 2021 to the CDC’s new v-safe surveillance system, which collects near–real-time data via smartphone text message prompts and web-based health surveys.

Medical News & Perspectives

Lead, Mistrust, and Trauma—Whistleblowing Pediatrician Discusses the Legacy of Flint’s Water Crisis

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JAMA. 2021;325(21):2136-2139. doi:10.1001/jama.2021.2314

This Medical News article is an interview with Mona Hanna-Attisha, MD, MPH, the Flint, Michigan, pediatrician who discovered elevated blood lead levels among children exposed to the city’s drinking water.

Start-ups Tout Continuous Glucose Monitoring for People Without Diabetes

Abstract Full Text
JAMA. 2021;325(21):2140-2142. doi:10.1001/jama.2021.3789

This Medical News article describes the marketing of continuous glucose monitoring devices to individuals without diabetes.

News From the Food and Drug Administration

Immunotherapy Approved for Endometrial Cancer

Abstract Full Text
JAMA. 2021;325(21):2143. doi:10.1001/jama.2021.8319

Helping Patients Improve Muscle Movement After Stroke

Abstract Full Text
JAMA. 2021;325(21):2143. doi:10.1001/jama.2021.7913

New Naloxone Dosage Is Approved

Abstract Full Text
JAMA. 2021;325(21):2143. doi:10.1001/jama.2021.8320
Poetry and Medicine

Prayer Whistle in the SARS-CoV-2 Ward

Abstract Full Text
JAMA. 2021;325(21):2213. doi:10.1001/jama.2021.1862
JAMA Revisited


Abstract Full Text
JAMA. 2021;325(21):2214. doi:10.1001/jama.2020.17966
JAMA Patient Page

Atrial Fibrillation

Abstract Full Text
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JAMA. 2021;325(21):2218. doi:10.1001/jama.2020.23700

This JAMA Patient Page describes atrial fibrillation, an irregular and often rapid heart rate, and its symptoms, diagnosis, and treatment options.

Comment & Response

Risks and Benefits of Benzodiazepines

Abstract Full Text
JAMA. 2021;325(21):2208-2209. doi:10.1001/jama.2021.4513

Risks and Benefits of Benzodiazepines

Abstract Full Text
JAMA. 2021;325(21):2209. doi:10.1001/jama.2021.4516

Risks and Benefits of Benzodiazepines—Reply

Abstract Full Text
JAMA. 2021;325(21):2209-2210. doi:10.1001/jama.2021.4522

APOE Allele Testing and Alzheimer Disease

Abstract Full Text
JAMA. 2021;325(21):2210-2211. doi:10.1001/jama.2021.4919

APOE Allele Testing and Alzheimer Disease—Reply

Abstract Full Text
JAMA. 2021;325(21):2211. doi:10.1001/jama.2021.4925

Incorrect Data in Table

Abstract Full Text
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JAMA. 2021;325(21):2211. doi:10.1001/jama.2021.7928
JAMA Masthead


Abstract Full Text
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JAMA. 2021;325(21):2133-2134. doi:10.1001/jama.2020.17963