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January 2023 - July 1883




June 15, 2021, Vol 325, No. 23, Pages 2327-2410

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;325(23):e2017989. doi:10.1001/jama.2020.17989
Original Investigation

Effects of Intravenous Eptinezumab vs Placebo on Headache Pain and Most Bothersome Symptom When Initiated During a Migraine Attack: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(23):2348-2356. doi:10.1001/jama.2021.7665

This randomized clinical trial assesses the effect of intravenous eptinezumab vs placebo on times to headache pain freedom and absence of most bothersome symptom (nausea, photophobia, or phonophobia) among patients experiencing a moderate to severe migraine attack.

Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis

Abstract Full Text
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JAMA. 2021;325(23):2357-2369. doi:10.1001/jama.2021.7939

This systematic review and meta-analysis assesses the benefits and harms associated with acute treatments for episodic migraine, including pharmacologic and nonpharmacologic therapies, with a focus on pain-related outcomes, function, and adverse events.

Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women

Abstract Full Text
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JAMA. 2021;325(23):2370-2380. doi:10.1001/jama.2021.7563

This study assesses the immunogenicity of the current COVID-19 mRNA vaccines in pregnant and lactating women against both the original SARS-CoV-2 USA-WA1/2020 strain as well as against the B.1.1.7 and B.1.351 variants of concern.

Research Letter

Public Trust and Willingness to Vaccinate Against COVID-19 in the US From October 14, 2020, to March 29, 2021

Abstract Full Text
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JAMA. 2021;325(23):2397-2399. doi:10.1001/jama.2021.8246

This online survey study of US adults characterizes trends in coronavirus vaccine hesitancy and public trust in vaccination before and after COVID-19 vaccine availability in the US.

Association of California’s Prescription Drug Coupon Ban With Generic Drug Use

Abstract Full Text
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JAMA. 2021;325(23):2399-2402. doi:10.1001/jama.2021.6568

This pharmacoepidemiology study uses insurance claims data to compare generic substitutions for drugs with vs without manufacturer copayment coupons in California vs surrounding states in the year before and after a January 2018 California ban on coupons intended to incentivize use of more expensive brand-name medication.


Restoring Vaccine Diplomacy

Abstract Full Text
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JAMA. 2021;325(23):2337-2338. doi:10.1001/jama.2021.7439

This Viewpoint discusses the importance of equitable international collaboration, innovative manufacturing and supply chain development, and shared governance to provide the billions of COVID-19 vaccine doses to the world’s low-income and low-resource populations that will be necessary to control the coronavirus pandemic.

A Population-Level Approach to Suicide Prevention

Abstract Full Text
JAMA. 2021;325(23):2339-2340. doi:10.1001/jama.2021.6678

This Viewpoint discusses the prospect that suicide prevention interventions at a population level could complement gains from individual-level approaches and help reverse the high toll of suicide in the US.

Coordination Needed to Address Clinician Well-being and the Opioid Epidemic

Abstract Full Text
JAMA. 2021;325(23):2341-2342. doi:10.1001/jama.2021.6694

This Viewpoint describes the connections between the US opioid use disorder (OUD) epidemic and crises in health care workforce well-being and describes a collaboration between the National Academy of Medicine (NAM) and Federation of State Medical Boards (FSMB) to address both and harmonize regulatory standards and practices where possible.

Promoting Trust and Morale by Changing How the Word Provider Is Used: Encouraging Specificity and Transparency

Abstract Full Text
JAMA. 2021;325(23):2343-2344. doi:10.1001/jama.2021.6046

This Viewpoint discusses the origins of the term provider as a reference to health care professionals, considers unintentional and potentially detrimental consequences of its use, and recommends replacement of the term with precise and respectful language that specifies the titles, roles, and responsibilities of people interacting with patients in health care settings.

A Piece of My Mind

New (Ab)normal: A Tale of 2 Pandemics

Abstract Full Text
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JAMA. 2021;325(23):2345. doi:10.1001/jama.2021.8757

In this narrative medicine essay, a neonatologist considers the differences in available COVID-19 resources between her native country India and her new home country the United States and describes her helpless feelings in aiding her family and friends in India.


Acute Treatment for Migraine: Contemporary Treatments and Future Directions

Abstract Full Text
JAMA. 2021;325(23):2346-2347. doi:10.1001/jama.2021.7275

Chronic Pelvic Pain in Women: A Review

Abstract Full Text
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JAMA. 2021;325(23):2381-2391. doi:10.1001/jama.2021.2631

This narrative review summarizes the evaluation and management of chronic pelvic pain using recommendations from consensus guidelines to facilitate clinical evaluation, treatment, improved care, and more positive patient-clinician interactions.

JAMA Insights

Women's Health

Autoimmune Thyroid Disease in Women

Abstract Full Text
JAMA. 2021;325(23):2392-2393. doi:10.1001/jama.2020.22196

This JAMA Insights narrative review discusses the relationship of thyroid autoantibodies to autoimmune thyroid disease and emphasizes the importance of age, fertility, and pregnancy when interpreting thyroid function test results.

From The Medical Letter on Drugs and Therapeutics

Drugs for Menopausal Symptoms

Abstract Full Text
JAMA. 2021;325(23):2394-2395. doi:10.1001/jama.2020.15592

This Medical Letter provides 2 Tables summarizing key information about drugs for menopausal symptoms published as part of a comprehensive review on the topic.

Medical News & Perspectives

Tackling the Misconception That Cystic Fibrosis Is a “White People’s Disease”

Abstract Full Text
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JAMA. 2021;325(23):2330-2332. doi:10.1001/jama.2021.5086

This Medical News feature examines racial and ethnic disparities in the diagnosis and treatment of cystic fibrosis.

Quick Uptakes

Despite Big Buildup, Few Benefit From Medicare’s Advance Care Planning Coverage

Abstract Full Text
JAMA. 2021;325(23):2333-2334. doi:10.1001/jama.2021.8402

This Medical News article describes research showing that few clinicians are using a Medicare benefit launched in 2016 to reimburse for discussing advance care planning with patients.

News From the Food and Drug Administration

Contaminated Water Is Suspected in Massive Salmonella Outbreak

Abstract Full Text
JAMA. 2021;325(23):2336. doi:10.1001/jama.2021.9227

Do Magnets in Consumer Electronics Disable Implanted Medical Devices?

Abstract Full Text
JAMA. 2021;325(23):2336. doi:10.1001/jama.2021.8898

Guidance to Develop Devices That Improve Glycemic Control

Abstract Full Text
JAMA. 2021;325(23):2336. doi:10.1001/jama.2021.9228
Global Health

More Comprehensive Care for Miscarriage Needed Worldwide

Abstract Full Text
JAMA. 2021;325(23):2335. doi:10.1001/jama.2021.8549

Drug-Resistant Malaria Detected in Africa Will Require Monitoring

Abstract Full Text
JAMA. 2021;325(23):2335. doi:10.1001/jama.2021.9133

Despite Improvements, COVID-19’s Health Care Disruptions Persist

Abstract Full Text
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JAMA. 2021;325(23):2335. doi:10.1001/jama.2021.9134
Poetry and Medicine

It Starts With the Brain

Abstract Full Text
JAMA. 2021;325(23):2406. doi:10.1001/jama.2021.6195
JAMA Revisited

Bacteria and the Telephone

Abstract Full Text
JAMA. 2021;325(23):2407. doi:10.1001/jama.2020.17990
JAMA Patient Page

Gallstones in Pregnancy

Abstract Full Text
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JAMA. 2021;325(23):2410. doi:10.1001/jama.2021.4502

This JAMA Patient Page describes the symptoms and complications of and the diagnosis and treatment options for gallstones in pregnant people.

Comment & Response

A Review of Acute Pancreatitis

Abstract Full Text
JAMA. 2021;325(23):2402. doi:10.1001/jama.2021.6012

A Review of Acute Pancreatitis

Abstract Full Text
JAMA. 2021;325(23):2402-2403. doi:10.1001/jama.2021.6009

A Review of Acute Pancreatitis

Abstract Full Text
JAMA. 2021;325(23):2403. doi:10.1001/jama.2021.6006

A Review of Acute Pancreatitis—Reply

Abstract Full Text
JAMA. 2021;325(23):2403-2404. doi:10.1001/jama.2021.6015

A Review of the Diagnosis and Treatment of Metastatic Colorectal Cancer

Abstract Full Text
JAMA. 2021;325(23):2404-2405. doi:10.1001/jama.2021.6021

A Review of the Diagnosis and Treatment of Metastatic Colorectal Cancer—Reply

Abstract Full Text
JAMA. 2021;325(23):2405. doi:10.1001/jama.2021.6027

Incorrect Positive Predictive Values Reported

Abstract Full Text
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JAMA. 2021;325(23):2405. doi:10.1001/jama.2021.5789
JAMA Masthead


Abstract Full Text
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JAMA. 2021;325(23):2327-2328. doi:10.1001/jama.2020.17987