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September 2021 - July 1883

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Issue

June 22/29, 2021, Vol 325, No. 24, Pages 2419-2513

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;325(24):e2018001. doi:10.1001/jama.2020.18001
Original Investigation

US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021

Abstract Full Text
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JAMA. 2021;325(24):2448-2456. doi:10.1001/jama.2021.7517

This study describes the reported US cases of cerebral venous sinus thrombosis (CVST) with thrombocytopenia following vaccination with Ad26.COV2.S, the COVID-19 vaccine produced by Janssen/Johnson & Johnson.

Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers

Abstract Full Text
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JAMA. 2021;325(24):2457-2465. doi:10.1001/jama.2021.7152

This cohort study estimates the association between Pfizer-BioNTech BNT162b2 vaccination and symptomatic and asymptomatic SARS-CoV-2 infections among health care workers more than 7 days after receipt of a second vaccine dose.

Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis

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JAMA. 2021;325(24):2466-2479. doi:10.1001/jama.2021.7872

This meta-analysis of 20 randomized trials reported in 6 clinical databases compares outcomes associated with dual therapy of inhaled corticosteroids (ICS) and long-acting β2-agonists (LABAs) vs triple therapy (ICS and LABA plus a long-acting muscarinic antagonist) in treating exacerbations in moderate to severe asthma.

Research Letter

Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination in a Routinely Screened Workforce

Abstract Full Text
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JAMA. 2021;325(24):2500-2502. doi:10.1001/jama.2021.6564

This study aims to describe an association between the Pfizer-BioNTech (BNT162b2) vaccine and decreased risk of symptomatic and asymptomatic infections with SARS-CoV-2 in hospital employees.

Association of Initial Treatment With Antibiotics vs Surgery With Treatment Success and Disability in Subgroups of Children With Uncomplicated Appendicitis

Abstract Full Text
JAMA. 2021;325(24):2502-2504. doi:10.1001/jama.2021.6710

This study investigates differences in 1-year outcomes by clinical and socioeconomic factors among US children with uncomplicated appendicitis who were treated with antibiotics vs surgery.

Viewpoint

When Vaccine Apathy, Not Hesitancy, Drives Vaccine Disinterest

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JAMA. 2021;325(24):2435-2436. doi:10.1001/jama.2021.7707

This Viewpoint explains how vaccine apathy rather than hesitancy may lead to population undervaccination, and uses marketing principles to explain how public health messaging might differ to persuade apathetic persons to be immunized to achieve more widespread COVID-19 protection.

Implementing High-Quality Primary Care: A Report From the National Academies of Sciences, Engineering, and Medicine

Abstract Full Text
JAMA. 2021;325(24):2437-2438. doi:10.1001/jama.2021.7430

This Viewpoint discusses a 2021 National Academies of Sciences, Engineering, and Medicine consensus report proposing patient-centered principles and recommendations to strengthen primary care services and systems, including payment and information technology reform and dedicated funding for primary care research.

A National Goal to Advance Health Equity Through Value-Based Payment

Abstract Full Text
JAMA. 2021;325(24):2439-2440. doi:10.1001/jama.2021.8562

This Viewpoint proposes payment reforms to incentivize health equity, including setting of national goals, equity audits of payment models independent of quality and cost, and creation of a payment equity learning and action network to guide the work of achieving payment equity goals.

Progress With the All of Us Research Program: Opening Access for Researchers

Abstract Full Text
JAMA. 2021;325(24):2441-2442. doi:10.1001/jama.2021.7702

This Viewpoint summarizes enrollment to date in the All of Us Research Program, a cohort study launched in 2018 designed to enroll ≥1 million participants, including those from historically underrepresented backgrounds, to diversify the human genome database and the infrastructure it is building to broadly share its data assets to improve and accelerate biomedical research.

A Piece of My Mind

Vaccinated but Not Protected—Living Immunocompromised During the Pandemic

Abstract Full Text
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JAMA. 2021;325(24):2443-2444. doi:10.1001/jama.2021.9321

In this narrative medicine essay, an internist, conflicted about returning to life before the COVID-19 pandemic, worries about her vulnerability to an infection she cannot fight even after vaccination.

Editorial

Assessing a Rare and Serious Adverse Event Following Administration of the Ad26.COV2.S Vaccine

Abstract Full Text
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JAMA. 2021;325(24):2445-2447. doi:10.1001/jama.2021.7637
Review

Transcatheter Treatment of Valvular Heart Disease: A Review

Abstract Full Text
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JAMA. 2021;325(24):2480-2494. doi:10.1001/jama.2021.2133

This narrative review provides an overview of the various types of transcatheter valve therapies for individuals with either mitral or aortic valve disease that are currently available in the US and in the European Union using data from clinical trials and recommendations from 1 clinical guideline.

JAMA Insights

The Pandemic Stay-at-Home Order and Opioid-Involved Overdose Fatalities

Abstract Full Text
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JAMA. 2021;325(24):2495-2496. doi:10.1001/jama.2021.6700

This JAMA Insights describes trends in opioid-involved deaths in Cook County, Illinois (including Chicago), over a 3-year period, with a focus on changes before, during, and after the statewide 11-week COVID-19 stay-at-home order, March-June 2020.

Clinical Update

Assessment of Depressive Symptoms in Medically Ill Patients

Abstract Full Text
JAMA. 2021;325(24):2497-2498. doi:10.1001/jama.2021.2320

This JAMA Insights Clinical Update proposes an algorithm to determine the cause of depression in people with chronic and severe medical illness and summarizes screening, diagnosis, and management recommendations.

Medical News & Perspectives

Community-Based Organizations Step Up to Confront HIV in Southern States

Abstract Full Text
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JAMA. 2021;325(24):2421-2423. doi:10.1001/jama.2021.8428

This Medical News article discussed the deeply rooted HIV epidemic in the US South and community-based efforts to provide prevention services and medical care.

Quick Uptakes

Could Statins Do More Than Lower Cholesterol in Patients With COVID-19?

Abstract Full Text
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JAMA. 2021;325(24):2424-2425. doi:10.1001/jama.2021.8201

This Quick Uptake examines what is known about the relationship between statin use and mortality risk in people with COVID-19.

News From the Centers for Disease Control and Prevention

Adults Lag Behind Children in Reduced Head Injuries From Biking

Abstract Full Text
JAMA. 2021;325(24):2428. doi:10.1001/jama.2021.9339

Botulism Guidelines Aim to Help Prepare Clinicians for Outbreaks

Abstract Full Text
JAMA. 2021;325(24):2428. doi:10.1001/jama.2021.8969
Clinical Trials Update

Online Exercise Plus Text Messages Improve Knee Osteoarthritis

Abstract Full Text
JAMA. 2021;325(24):2427. doi:10.1001/jama.2021.8750

Vagus Nerve Stimulation Restores Arm Function Years After Stroke

Abstract Full Text
JAMA. 2021;325(24):2427. doi:10.1001/jama.2021.9693

Tranexamic Acid Reduces Blood Loss After Cesarean, but Not by Much

Abstract Full Text
JAMA. 2021;325(24):2427. doi:10.1001/jama.2021.9694

Hospital-at-Home Rivals Inpatient Care for Some Older Adults

Abstract Full Text
JAMA. 2021;325(24):2427. doi:10.1001/jama.2021.9695

Ready-to-Use Glucagon Analogue Quickly Reverses Hypoglycemia

Abstract Full Text
JAMA. 2021;325(24):2427. doi:10.1001/jama.2021.9696
Health Agencies Update

Funding for Rural COVID-19 Care

Abstract Full Text
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JAMA. 2021;325(24):2426. doi:10.1001/jama.2021.8995

Vaccination in Residential Facilities

Abstract Full Text
JAMA. 2021;325(24):2426. doi:10.1001/jama.2021.9727

NIH Addresses COVID-19 Disparities

Abstract Full Text
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JAMA. 2021;325(24):2426. doi:10.1001/jama.2021.9728
Poetry and Medicine

His Service Dog

Abstract Full Text
JAMA. 2021;325(24):2508. doi:10.1001/jama.2021.7349
JAMA Revisited

Book Notices

Abstract Full Text
JAMA. 2021;325(24):2509. doi:10.1001/jama.2020.18002
JAMA Patient Page

Artificial Heart Valves

Abstract Full Text
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JAMA. 2021;325(24):2512-2513. doi:10.1001/jama.2020.19936

This JAMA Patient Page describes the techniques used to replace damaged heart valves with mechanical or tissue-based artificial valves.

Comment & Response

Review of Hip and Knee Osteoarthritis

Abstract Full Text
JAMA. 2021;325(24):2504-2505. doi:10.1001/jama.2021.6018

Review of Hip and Knee Osteoarthritis—Reply

Abstract Full Text
JAMA. 2021;325(24):2505. doi:10.1001/jama.2021.6024

Effect of Restrictive or Liberal Blood Transfusion on Major Cardiovascular Events in Patients With Acute Myocardial Infarction and Anemia

Abstract Full Text
JAMA. 2021;325(24):2505-2506. doi:10.1001/jama.2021.6033

Effect of Restrictive or Liberal Blood Transfusion on Major Cardiovascular Events in Patients With Acute Myocardial Infarction and Anemia—Reply

Abstract Full Text
JAMA. 2021;325(24):2506-2507. doi:10.1001/jama.2021.6039
Correction

Addition of Nonauthor Collaborator Names of the INTUBE Study Collaborators

Abstract Full Text
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JAMA. 2021;325(24):2507. doi:10.1001/jama.2021.9012
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2021;325(24):2419-2420. doi:10.1001/jama.2020.17999
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