This noninferiority trial compares the effects of endovascular treatment with vs without intravenous alteplase on 90-day functional independence among patients with acute ischemic stroke.
This noninferiority trial compares the effects of mechanical thrombectomy with vs without intravenous thrombolysis (0.6-mg/kg alteplase) on 90-day disability among patients with acute large vessel occlusive ischemic stroke.
This randomized clinical trial compares the effect of discontinuing vs continuing angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on days alive and out of the hospital at 30 days among patients with COVID-19 taking the drugs prior to hospitalization.
This study describes reasons for readmission, use of ICU interventions during readmission, and proportions of death after initial hospital discharge of COVID-19 patients from US Veterans Affairs (VA) hospitals in March-June 2020.
This 2021 US Preventive Services Task Force Recommendation Statement recommends that clinicians ask all adults about tobacco use, advise them to stop using tobacco, and provide behavioral interventions and pharmacotherapy for cessation (A recommendation) and concludes that evidence is insufficient to assess the benefits and harms of tobacco cessation pharmacotherapy in pregnant persons and e- cigarettes for tobacco cessation in any adult (I statement).
This systematic review to support the 2021 US Preventive Services Task Force Recommendation Statement on interventions for tobacco cessation in adults summarizes published evidence on the benefits and harms of interventions for tobacco cessation in adults, including pregnant persons.
This Viewpoint posits that the US will engage in another debate about health care reform to consider expanding coverage, improving affordability, and containing costs.
This Viewpoint proposes measures the incoming Biden administration can take to increase access to health insurance coverage under the Affordable Care Act (ACA) and Medicaid, including limiting short-term ACA coverage provisions, rolling back state Medicaid waivers, and simplifying Medicaid eligibility.
This Viewpoint proposes that prioritizing all placebo-group participants in coronavirus vaccine trials as vaccine first receivers could perpetuate health inequities and compromise the chance to learn from their participation, proposing instead to limit prioritization to placebo participants who would be prioritized for vaccination anyway under NASEM or ACIP frameworks.
This Viewpoint discusses the ethics of including a placebo arm in randomized trials of coronavirus vaccines once authorized vaccines have become widely available, and proposes use of adaptive platform trial designs as an optimal approach to nimbly and ethically compare future investigational COVID-19 vaccines with proven effective ones.
This Viewpoint discusses the rapid spread of scientific misinformation on social media platforms throughout the COVID-19 pandemic and proposes strategies to counteract its adverse effects including surveillance of digital data and partnering with trusted messengers to engage the public and advance scientifically sound public health measures.
In this narrative medicine essay, a neonatologist describes the fear of losing her twin boys after assisted reproduction and their premature births and relies on a form of root cause analysis to identify the sources of her trauma and to learn from it enough to support her patients and their families.
This JAMA Performance Improvement article summarizes findings from an international survey study of hospital experience with central venous access line insertion teams to manage high procedural volume and safety during the COVID-19 pandemic.
This JAMA Clinical Guidelines Synopsis summarizes the American Thoracic Society’s 2020 recommendations for treating tobacco dependence with pharmacologic therapy in adults.
This Medical News article is an interview with communication science expert Brian Southwell, PhD, whose new training workshop helps clinicians navigate medical misinformation.
This story describes guidelines to help people with type 1 diabetes respond to readings on glucose monitors before, during, and after exercise.
This JAMA Patient Page summarizes the USPSTF 2020 guideline recommending that physicians ask all adults about tobacco use, advise them to stop using tobacco, and provide behavioral interventions and drugs shown effective for stopping cigarette and other tobacco use.
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