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January 2023 - July 1883

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February 2, 2021, Vol 325, No. 5, Pages 415-500

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;325(5):e2017773. doi:10.1001/jama.2020.17773
Original Investigation

Association Between County-Level Change in Economic Prosperity and Change in Cardiovascular Mortality Among Middle-aged US Adults

Abstract Full Text
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JAMA. 2021;325(5):445-453. doi:10.1001/jama.2020.26141

This population epidemiology study estimates the association between changes in county-level economic prosperity and changes in cardiovascular mortality in US adults aged 40 to 64 years between 2007-2011 and 2012-2016.

Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin

Abstract Full Text
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JAMA. 2021;325(5):454-466. doi:10.1001/jama.2020.26345

This cohort study compares global disability at 3 months among Berlin patients with out-of-hospital ischemic stroke brought to care via a mobile stroke unit ambulance (with prehospital CT scanning with or without angiography, point-of-care laboratory testing, prehospital thrombolysis) vs conventional ambulance alone.

Molecular Diagnostic Yield of Exome Sequencing in Patients With Cerebral Palsy

Abstract Full Text
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JAMA. 2021;325(5):467-475. doi:10.1001/jama.2020.26148

This cross-sectional study describes the prevalence of pathogenic and likely pathogenic variants detected on exome sequencing of children and adults with cerebral palsy referred for genetic testing.

Research Letter

Screening for Asymptomatic Carotid Artery Stenosis in the General Population: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Abstract Full Text
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JAMA. 2021;325(5):487-489. doi:10.1001/jama.2020.20364

This systematic review to support the 2021 US Preventive Services Task Force Reaffirmation Recommendation Statement on screening for carotid artery stenosis summarizes published evidence on the benefits and harms of screening and treatment of asymptomatic carotid artery stenosis in the general population.

Asymptomatic SARS-CoV-2 Infections Among Persons Entering China From April 16 to October 12, 2020

Abstract Full Text
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JAMA. 2021;325(5):489-492. doi:10.1001/jama.2020.23942

This population epidemiology study characterizes trends in the prevalence of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among international entrants testing positive for SARS-CoV-2 at Chinese border checkpoints between mid-April and mid-October 2020.

US Preventive Services Task Force

Recommendation Statement

Screening for Asymptomatic Carotid Artery Stenosis: US Preventive Services Task Force Recommendation Statement

Abstract Full Text
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JAMA. 2021;325(5):476-481. doi:10.1001/jama.2020.26988

This 2021 US Preventive Services Task Force Recommendation Statement recommends against screening for asymptomatic carotid artery stenosis in the general adult population (D recommendation).

Viewpoint

Health Policy

Reducing Administrative Waste in the US Health Care System

Abstract Full Text
JAMA. 2021;325(5):427-428. doi:10.1001/jama.2020.24767

This Viewpoint reviews the history and sources of administrative waste in the US health care system and proposes concrete ways the federal government can use its regulatory authority to reduce it based on the ACA and more recent legislative precedents.

Ensuring Quality in the Era of Virtual Care

Abstract Full Text
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JAMA. 2021;325(5):429-430. doi:10.1001/jama.2020.24955

This Viewpoint discusses residual questions about virtual health care as a substitute for in-person visits during the COVID-19 pandemic and proposes principles of safety, effectiveness, efficiency, patient-centeredness, and equitability to guide the growth of telehealth care in the future.

Paying for Telemedicine After the Pandemic

Abstract Full Text
JAMA. 2021;325(5):431-432. doi:10.1001/jama.2020.25706

This Viewpoint discusses the importance of value as policy makers consider the role of telemedicine for the remainder of and following the COVID-19 pandemic, and how to calibrate payment for services to that value in a likely expansion of video and audio-only visits.

Obesity Management in Women of Reproductive Age

Abstract Full Text
JAMA. 2021;325(5):433-434. doi:10.1001/jama.2020.21096

This Viewpoint summarizes obstetric complications of overweight and obesity, including adverse pregnancy outcomes, gestational diabetes, and hypertensive disorders, and reviews weight management options available to patients and their treating physicians.

A Piece of My Mind

The In-between

Abstract Full Text
JAMA. 2021;325(5):435-436. doi:10.1001/jama.2020.25885

In this narrative medicine essay, a geriatrician memory of a neuroradiology fellow’s words of calm when breaking the news that her 8-year-old daughter had a brain tumor often bubbles up years later when she breaks bad news to patients with COVID who are without the support of friends or family.

Editorial

Virtual Care, Telemedicine Visits, and Real Connection in the Era of COVID-19: Unforeseen Opportunity in the Face of Adversity

Abstract Full Text
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JAMA. 2021;325(5):437-438. doi:10.1001/jama.2020.27304

Economic Prosperity and Cardiovascular Mortality: Further Evidence That All Policy Is Health Policy

Abstract Full Text
JAMA. 2021;325(5):439-440. doi:10.1001/jama.2020.26717

Improving Stroke Treatment and Outcomes With Mobile Stroke Units

Abstract Full Text
JAMA. 2021;325(5):441-442. doi:10.1001/jama.2020.25832

Screening for Asymptomatic Carotid Artery Stenosis: Lack of Clinical Benefit, Potential for Harm

Abstract Full Text
has audio
JAMA. 2021;325(5):443-444. doi:10.1001/jama.2020.26440
JAMA Clinical Guidelines Synopsis

Management of Immunotherapy-Related Toxicities in Patients Treated With Immune Checkpoint Inhibitor Therapy

Abstract Full Text
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JAMA. 2021;325(5):482-483. doi:10.1001/jama.2020.17308

This JAMA Clinical Guidelines Synopsis summarizes the National Comprehensive Cancer Network’s 2019 guidelines on management of immunotherapy-related toxicities, including adverse skin reaction, colitis, and myocarditis.

JAMA Diagnostic Test Interpretation

APOE ɛ4 Allele Testing and Risk of Alzheimer Disease

Abstract Full Text
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JAMA. 2021;325(5):484-485. doi:10.1001/jama.2020.15085

A 64-year-old man underwent APOE ɛ4 allele testing for 3 years of forgetfulness and word-finding difficulties and a family history of early-onset dementia, with results positive for genotypes 3 and 4 indicating “with high specificity, that Alzheimer’s disease is the cause of or a contributor to the observed dementia.” What would you do next?

Medical News & Perspectives

Therapists Donate Their Time to Counsel Distressed Health Care Workers

Abstract Full Text
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JAMA. 2021;325(5):420-422. doi:10.1001/jama.2020.25689

This Medical News article describes organizations that have recruited therapists to offer free or discounted mental health services to health care workers during the COVID-19 pandemic.

News From the Food and Drug Administration

Adjuvant Therapy Approved for NSCLC

Abstract Full Text
JAMA. 2021;325(5):426. doi:10.1001/jama.2021.0168

Tighter Requirements to Ensure Safer Opioid Prescribing

Abstract Full Text
JAMA. 2021;325(5):426. doi:10.1001/jama.2021.0050

Dedicated Device Permits Less Invasive Pancreatic Surgery

Abstract Full Text
JAMA. 2021;325(5):426. doi:10.1001/jama.2021.0170
The JAMA Forum

Dying Poor in the US—Disparities in End-of-Life Care

Abstract Full Text
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JAMA. 2021;325(5):423-424. doi:10.1001/jama.2020.26162
Bench to Bedside

Autoantibodies May Drive COVID-19 Blood Clots

Abstract Full Text
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JAMA. 2021;325(5):425. doi:10.1001/jama.2020.25699
The Arts and Medicine

Innocence in America—Reading James Baldwin in 2020

Abstract Full Text
JAMA. 2021;325(5):418-419. doi:10.1001/jama.2020.22102

This Arts and Medicine feature offers an appreciation of mid-20th century novelist, essayist, memoirist, and civil rights activist James Baldwin and argues for his continuing relevance to medicine and society at large.

Poetry and Medicine

I Dream of Animals During the Pandemic

Abstract Full Text
JAMA. 2021;325(5):495. doi:10.1001/jama.2020.22849
JAMA Revisited

Current Comment

Abstract Full Text
JAMA. 2021;325(5):496. doi:10.1001/jama.2020.17774
JAMA Patient Page

Screening for Carotid Artery Stenosis

Abstract Full Text
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JAMA. 2021;325(5):500. doi:10.1001/jama.2021.0035

This JAMA Patient Page summarizes the US Preventive Services Task Force’s 2021 recommendation not to screen for asymptomatic carotid artery stenosis in the general population.

Comment & Response

Determination of Brain Death

Abstract Full Text
JAMA. 2021;325(5):492. doi:10.1001/jama.2020.23228

Determination of Brain Death

Abstract Full Text
JAMA. 2021;325(5):492-493. doi:10.1001/jama.2020.23222

Determination of Brain Death

Abstract Full Text
JAMA. 2021;325(5):493. doi:10.1001/jama.2020.23225

Determination of Brain Death

Abstract Full Text
JAMA. 2021;325(5):493-494. doi:10.1001/jama.2020.23231

Determination of Brain Death—Reply

Abstract Full Text
JAMA. 2021;325(5):494. doi:10.1001/jama.2020.23234
Correction

Errors in Figure Labels

Abstract Full Text
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JAMA. 2021;325(5):494. doi:10.1001/jama.2020.27059
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2021;325(5):415-416. doi:10.1001/jama.2020.17771
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