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October 2021 - July 1883

Decade

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Issue

February 9, 2021, Vol 325, No. 6, Pages 507-596

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;325(6):e2017785. doi:10.1001/jama.2020.17785
Original Investigation

Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(6):542-551. doi:10.1001/jama.2020.26812

This randomized trial compares the effects of high-intensity interval training, moderate continuous training, and guideline-based physical activity on change in peak oxygen consumption (V̇o2) in patients with heart failure with preserved ejection fraction (HFpEF).

Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial

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JAMA. 2021;325(6):552-560. doi:10.1001/jama.2021.0135

This noninferiority trial compares the effects of a restrictive (hemoglobin ≤8 g/dL) vs liberal (hemoglobin ≤10 g/dL) transfusion strategy on 30-day cardiovascular events among adults with acute myocardial infarction (AMI) and anemia (hemoglobin 7-10 g/dL).

Prevalence of Bicuspid Aortic Valve and Associated Aortopathy in Newborns in Copenhagen, Denmark

Abstract Full Text
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JAMA. 2021;325(6):561-567. doi:10.1001/jama.2020.27205

This population epidemiology study describes the prevalence of bicuspid aortic valve (BAV) and BAV subtypes, and of accompanying enlarged aortic diameter or coarctation, in Danish newborns born in Copenhagen 2016-2018.

Research Letter

Prevalence and Outcomes of SARS-CoV-2 Infection Among Migrant Workers in Singapore

Abstract Full Text
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JAMA. 2021;325(6):584-585. doi:10.1001/jama.2020.24071

This study examines the prevalence and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among migrant workers in Singapore.

Viewpoint

Health Policy

The COVID-19 Pandemic as an Opportunity to Ensure a More Successful Future for Science and Public Health

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JAMA. 2021;325(6):525-526. doi:10.1001/jama.2020.23479

This Viewpoint suggests that the COVID-19 pandemic provides an opportunity to build trust in science and update federal agencies to improve public health and poses questions and offers recommendations for consideration.

Health Policy

Cancer Care Under the Biden Administration

Abstract Full Text
JAMA. 2021;325(6):527-528. doi:10.1001/jama.2020.25424

This Viewpoint evaluates Biden’s health care proposals to help reduce the cost burden on patients with cancer should they be enacted legislatively.

Genetic Variants of SARS-CoV-2—What Do They Mean?

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JAMA. 2021;325(6):529-531. doi:10.1001/jama.2020.27124

This Viewpoint discusses emerging genetic variants of SARS-CoV-2, including new “UK” and “mink” variants and the significance of the new variants to coronavirus transmissibility, spread, virulence, and efforts to vaccinate the population against COVID-19.

Mandating COVID-19 Vaccines

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JAMA. 2021;325(6):532-533. doi:10.1001/jama.2020.26553

This Viewpoint discusses whether US states, businesses, health care facilities, and schools and universities can mandate vaccination against coronavirus as a condition of employment or service.

Problems With Paying People to Be Vaccinated Against COVID-19

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JAMA. 2021;325(6):534-535. doi:10.1001/jama.2020.27121

This Viewpoint describes features of 2 proposals to pay US residents to be vaccinated against COVID-19 and proposes ethical and practical complications of the plans, arguing that they are morally suspect, likely unnecessary, and may be counterproductive.

A Piece of My Mind

Donning and Doffing

Abstract Full Text
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JAMA. 2021;325(6):536. doi:10.1001/jama.2020.26468

In this narrative medicine essay an internal medicine hospitalist explores what the new diagnosis of breast cancer means for her professional identity and considers how the COVID-19 pandemic facilitates the hiding of serious illness but also complicates disclosing the news to colleagues and friends.

Editorial

Searching for the Optimal Exercise Training Regimen in Heart Failure With Preserved Ejection Fraction

Abstract Full Text
JAMA. 2021;325(6):537-539. doi:10.1001/jama.2020.26347

Bicuspid Aortic Valve—A Common Form of Structural Heart Disease

Abstract Full Text
JAMA. 2021;325(6):540-541. doi:10.1001/jama.2021.0109
Review

Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review

Abstract Full Text
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JAMA. 2021;325(6):568-578. doi:10.1001/jama.2020.22171

This narrative review summarizes the pathophysiology, diagnosis, and treatment of osteoarthritis (OA) of the hip and knee, including use of structured exercise, acetaminophen and NSAIDs, corticosteroid injections, and surgery to manage symptoms.

JAMA Clinical Challenge

An 18-Month History of Dorsal Foot Lesions

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JAMA. 2021;325(6):579-580. doi:10.1001/jama.2020.16053

A 32-year-old Nigerian woman with a childhood transfusion history developed scaly plaques with cobblestone surfaces on the dorsum of the forefoot and midfoot bilaterally; serologic testing was negative for HIV and positive for hepatitis C virus. What is the diagnosis and what would you do next?

From The Medical Letter on Drugs and Therapeutics

Drugs for Osteoarthritis

Abstract Full Text
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JAMA. 2021;325(6):581-582. doi:10.1001/jama.2020.8395

This Medical Letter review reproduces a Table summarizing key information about drugs for osteoarthritis published as part of a comprehensive review on the topic.

Medical News & Perspectives

Helping People Who Are Homeless Stay Healthy During the Pandemic

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JAMA. 2021;325(6):517-519. doi:10.1001/jama.2020.23436

This Medical News story profiles Harvard dermatologist Jennifer Tan, MD, who helps care for people experiencing homelessness.

The JAMA Forum

Social Isolation and Loneliness: Imperatives for Health Care in a Post-COVID World

Abstract Full Text
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JAMA. 2021;325(6):520-521. doi:10.1001/jama.2021.0100
News From the Centers for Disease Control and Prevention

Updated Recommendations for Gonorrhea Treatment

Abstract Full Text
JAMA. 2021;325(6):523. doi:10.1001/jama.2021.0241

Accelerated Overdose Deaths Linked With COVID-19

Abstract Full Text
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JAMA. 2021;325(6):523. doi:10.1001/jama.2021.0074
Biotech Innovations

CRISPR-Based COVID-19 Smartphone Test in Development

Abstract Full Text
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JAMA. 2021;325(6):522. doi:10.1001/jama.2021.0493

Predicting COVID-19 Outcomes in Emergency Department Patients

Abstract Full Text
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JAMA. 2021;325(6):522. doi:10.1001/jama.2021.0227

Phone Apps and Wearable Trackers Modestly Improve Activity

Abstract Full Text
JAMA. 2021;325(6):522. doi:10.1001/jama.2021.0495
The Arts and Medicine

Death by Massive Hemorrhage in Robert Frost’s “Out, Out–”: A Plea to the Immediate Responder

Abstract Full Text
JAMA. 2021;325(6):515-516. doi:10.1001/jama.2020.24787

This Arts and Medicine feature uses poet Robert Frost’s poem “Out, Out–”, about the tragic death of a boy in the premodern era from a work injury and hemorrhagic shock, to discuss the stakes of developing a more effective public health response to traumatic injury.

Poetry and Medicine

To a Firstborn Son

Abstract Full Text
JAMA. 2021;325(6):590. doi:10.1001/jama.2020.23816
JAMA Revisited

Income Tax Credit for Charity Practice of Physicians

Abstract Full Text
JAMA. 2021;325(6):591. doi:10.1001/jama.2020.17786
JAMA Patient Page

Treatment of Alcohol Use Disorder

Abstract Full Text
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JAMA. 2021;325(6):596. doi:10.1001/jama.2020.2012

This JAMA Patient Page explains the medications (naltrexone, acamprosate, disulfiram) and behavioral treatments (cognitive behavior therapy [CBT]) used to manage alcohol use disorder.

Comment & Response

Financing of US Graduate Medical Education

Abstract Full Text
JAMA. 2021;325(6):585-586. doi:10.1001/jama.2020.23979

Financing of US Graduate Medical Education—Reply

Abstract Full Text
JAMA. 2021;325(6):586. doi:10.1001/jama.2020.23988

Update on Blood Pressure Control Among US Adults With Hypertension

Abstract Full Text
JAMA. 2021;325(6):586-587. doi:10.1001/jama.2020.23982

Update on Blood Pressure Control Among US Adults With Hypertension—Reply

Abstract Full Text
JAMA. 2021;325(6):587-588. doi:10.1001/jama.2020.23991

Algorithmic Stewardship in Health Care

Abstract Full Text
JAMA. 2021;325(6):588. doi:10.1001/jama.2020.24100

Algorithmic Stewardship in Health Care—Reply

Abstract Full Text
JAMA. 2021;325(6):588-589. doi:10.1001/jama.2020.24103
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2021;325(6):507-508. doi:10.1001/jama.2020.17783
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