This randomized clinical trial compares the effects of high-dose baclofen vs placebo on agitation-related events among adults in the ICU with unhealthy alcohol use receiving mechanical ventilation.
This randomized trial compares the effect of vitamin C, thiamine, and hydrocortisone vs matching placebo on 30-day ventilator- and vasopressor-free days among patients with sepsis-induced respiratory and/or cardiovascular dysfunction.
This case-control study uses whole-exome sequencing to identify coding-sequence genetic variants associated with exfoliation syndrome, a form of glaucoma caused by abnormal fibrillar protein aggregates in the anterior eye.
This study compares all-cause excess mortality and COVID-19–related mortality during the early pandemic period (March-July 2020) with unintentional drug overdoses, the usual leading cause of death in young adults, during the same period in 2018 among adults aged 25 to 44 years.
This Viewpoint discusses the unexpected large billing that can occur when a patient receives care from an out-of-network physician or center (surprise billing)—its root causes and recent legislation that will provide some patients with protection, but not all.
This Viewpoint lays out policy priorities for advancing the digital transformation of US health information systems, including funding of infrastructure and enforcement of standards for EHR interoperability, data sharing, and usability.
This Viewpoint reviews data demonstrating worse risk and outcomes for non-White patients with coronavirus disease 2019 (COVID-19) and makes policy proposals to mitigate the disparities, including expansion of Medicaid eligibility to expand health care access, multilingual and culturally appropriate communication and outreach, and easing accessibility to social services through health care contacts to address housing, food, legal, and economic stressors.
This Viewpoint reviews the system in place to compensate US residents for proven vaccine injury via the Countermeasures Injury Compensation Program and emphasizes that the benefit of COVID-19 vaccines outweighs any potential harm.
This Viewpoint proposes response options for specialty societies, medical licensing boards, academic leadership, and faculty and colleagues when physician public health leaders spread misinformation detrimental to patients’ or the public’s health, as happened in the first year of the COVID-19 pandemic.
In this narrative medicine essay, a medical school professor expresses gratitude for the caring and empathy expressed by the team caring for her mother hospitalized with COVID-19 and emphasizes the importance of humanity and compassion over facts and statistics for families physically separated from their critically ill loved ones.
This narrative review discusses the epidemiology and pathophysiology of multiple sclerosis and summarizes current evidence on its diagnosis and treatment using disease-modifying therapies and nonpharmacological interventions.
This JAMA Insights review provides clinical details of anaphylactic reactions reported to and verified by the CDC in the first week of use of the Pfizer-BioNTech COVID-19 vaccine in the US, December 14-23, 2020.
A 48-year-old man had erythema without warmth over his right ankle and dorsomedial foot, with nontender, nonpalpable purpura over the foot dorsum and scattered petechiae over the right lower leg 6 weeks after immobilization for an ankle fracture; temperature was 38.2°C (100.8°F) and the erythema faded when he elevated his leg above heart level. What is the diagnosis and what would you do next?
This Medical News article describes how clinicians can explain to patients that their adverse effects may be due to the nocebo effect, which has more to do with negative perceptions than with a drug’s pharmacological action.
This JAMA Patient Page describes the types, causes, and treatment of nystagmus, a rhythmic involuntary movement of the eyes.
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