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October 2021 - July 1883

Decade

Year

Issue

February 23, 2021, Vol 325, No. 8, Pages 705-798

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;325(8):e2017809. doi:10.1001/jama.2020.17809
Original Investigation

Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(8):732-741. doi:10.1001/jama.2021.0658

This randomized clinical trial compares the effects of high-dose baclofen vs placebo on agitation-related events among adults in the ICU with unhealthy alcohol use receiving mechanical ventilation.

Caring for the Critically Ill Patient

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(8):742-750. doi:10.1001/jama.2020.24505

This randomized trial compares the effect of vitamin C, thiamine, and hydrocortisone vs matching placebo on 30-day ventilator- and vasopressor-free days among patients with sepsis-induced respiratory and/or cardiovascular dysfunction.

Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye

Abstract Full Text
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JAMA. 2021;325(8):753-764. doi:10.1001/jama.2021.0507

This case-control study uses whole-exome sequencing to identify coding-sequence genetic variants associated with exfoliation syndrome, a form of glaucoma caused by abnormal fibrillar protein aggregates in the anterior eye.

Research Letter

All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020

Abstract Full Text
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JAMA. 2021;325(8):785-787. doi:10.1001/jama.2020.24243

This study compares all-cause excess mortality and COVID-19–related mortality during the early pandemic period (March-July 2020) with unintentional drug overdoses, the usual leading cause of death in young adults, during the same period in 2018 among adults aged 25 to 44 years.

Viewpoint

Health Policy

Surprise Billing—A Flashpoint for Major Policy Issues in Health Care

Abstract Full Text
JAMA. 2021;325(8):715-716. doi:10.1001/jama.2020.26779

This Viewpoint discusses the unexpected large billing that can occur when a patient receives care from an out-of-network physician or center (surprise billing)—its root causes and recent legislation that will provide some patients with protection, but not all.

Health Policy

From Digitization to Digital Transformation: Policy Priorities for Closing the Gap

Abstract Full Text
JAMA. 2021;325(8):717-718. doi:10.1001/jama.2020.27014

This Viewpoint lays out policy priorities for advancing the digital transformation of US health information systems, including funding of infrastructure and enforcement of standards for EHR interoperability, data sharing, and usability.

Racial and Ethnic Health Disparities Related to COVID-19

Abstract Full Text
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JAMA. 2021;325(8):719-720. doi:10.1001/jama.2020.26443

This Viewpoint reviews data demonstrating worse risk and outcomes for non-White patients with coronavirus disease 2019 (COVID-19) and makes policy proposals to mitigate the disparities, including expansion of Medicaid eligibility to expand health care access, multilingual and culturally appropriate communication and outreach, and easing accessibility to social services through health care contacts to address housing, food, legal, and economic stressors.

A Viral Pandemic, Vaccine Safety, and Compensation for Adverse Events

Abstract Full Text
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JAMA. 2021;325(8):721-722. doi:10.1001/jama.2020.26792

This Viewpoint reviews the system in place to compensate US residents for proven vaccine injury via the Countermeasures Injury Compensation Program and emphasizes that the benefit of COVID-19 vaccines outweighs any potential harm.

When Physicians Engage in Practices That Threaten the Nation’s Health

Abstract Full Text
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JAMA. 2021;325(8):723-724. doi:10.1001/jama.2021.0122

This Viewpoint proposes response options for specialty societies, medical licensing boards, academic leadership, and faculty and colleagues when physician public health leaders spread misinformation detrimental to patients’ or the public’s health, as happened in the first year of the COVID-19 pandemic.

A Piece of My Mind

COVID-19 Communication—The Need for Humanity, Empathy, and Grace

Abstract Full Text
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JAMA. 2021;325(8):725-726. doi:10.1001/jama.2021.0119

In this narrative medicine essay, a medical school professor expresses gratitude for the caring and empathy expressed by the team caring for her mother hospitalized with COVID-19 and emphasizes the importance of humanity and compassion over facts and statistics for families physically separated from their critically ill loved ones.

Editorial

Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU

Abstract Full Text
JAMA. 2021;325(8):727-729. doi:10.1001/jama.2021.0597

Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter

Abstract Full Text
JAMA. 2021;325(8):730-731. doi:10.1001/jama.2020.26029
Review

Diagnosis and Treatment of Multiple Sclerosis: A Review

Abstract Full Text
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JAMA. 2021;325(8):765-779. doi:10.1001/jama.2020.26858

This narrative review discusses the epidemiology and pathophysiology of multiple sclerosis and summarizes current evidence on its diagnosis and treatment using disease-modifying therapies and nonpharmacological interventions.

JAMA Insights

Clinical Update

Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine

Abstract Full Text
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JAMA. 2021;325(8):780-781. doi:10.1001/jama.2021.0600

This JAMA Insights review provides clinical details of anaphylactic reactions reported to and verified by the CDC in the first week of use of the Pfizer-BioNTech COVID-19 vaccine in the US, December 14-23, 2020.

JAMA Clinical Challenge

A Purpuric Rash

Abstract Full Text
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JAMA. 2021;325(8):782-783. doi:10.1001/jama.2020.19186

A 48-year-old man had erythema without warmth over his right ankle and dorsomedial foot, with nontender, nonpalpable purpura over the foot dorsum and scattered petechiae over the right lower leg 6 weeks after immobilization for an ankle fracture; temperature was 38.2°C (100.8°F) and the erythema faded when he elevated his leg above heart level. What is the diagnosis and what would you do next?

Editor's Note

Funding and DSMB Membership in the VICTAS Clinical Trial

Abstract Full Text
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JAMA. 2021;325(8):751-752. doi:10.1001/jama.2020.25952
Medical News & Perspectives

“Important Conversations” Are Needed to Explain the Nocebo Effect

Abstract Full Text
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JAMA. 2021;325(8):707-709. doi:10.1001/jama.2020.25840

This Medical News article describes how clinicians can explain to patients that their adverse effects may be due to the nocebo effect, which has more to do with negative perceptions than with a drug’s pharmacological action.

The JAMA Forum

From Economic Recovery to Health Resilience

Abstract Full Text
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JAMA. 2021;325(8):710-711. doi:10.1001/jama.2020.24936
News From the Centers for Disease Control and Prevention

COVID-19 Rates Increased Where In-Person College Classes Were Held

Abstract Full Text
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JAMA. 2021;325(8):714. doi:10.1001/jama.2021.0621

Drug-Resistant Yeast Infections Spread in COVID-19 Unit

Abstract Full Text
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JAMA. 2021;325(8):714. doi:10.1001/jama.2021.1031
Clinical Trials Update

Oral Rimegepant Safe, Effective for Migraine Prevention

Abstract Full Text
JAMA. 2021;325(8):713. doi:10.1001/jama.2021.0651

Finerenone for Patients With CKD and Type 2 Diabetes

Abstract Full Text
JAMA. 2021;325(8):713. doi:10.1001/jama.2021.1255

Common Weight Loss Surgeries’ Benefits Sustained at Year 7

Abstract Full Text
JAMA. 2021;325(8):713. doi:10.1001/jama.2021.1257

Navigators Improve Autism Evaluations but Not Referrals to Care

Abstract Full Text
JAMA. 2021;325(8):713. doi:10.1001/jama.2021.1259

Physician Videos Improve COVID-19 Knowledge Among Minorities

Abstract Full Text
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JAMA. 2021;325(8):713. doi:10.1001/jama.2021.1261
Health Agencies Update

Collecting Data About COVID-19–Related Brain Symptoms

Abstract Full Text
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JAMA. 2021;325(8):712. doi:10.1001/jama.2021.0791

Detecting Heart Transplant Rejection Earlier, More Easily

Abstract Full Text
JAMA. 2021;325(8):712. doi:10.1001/jama.2021.1228

Locating COVID-19 Monoclonal Antibody Therapies

Abstract Full Text
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JAMA. 2021;325(8):712. doi:10.1001/jama.2021.1230
Poetry and Medicine

Knows

Abstract Full Text
JAMA. 2021;325(8):792. doi:10.1001/jama.2020.23939
JAMA Revisited

The Worth of a Miracle

Abstract Full Text
JAMA. 2021;325(8):793. doi:10.1001/jama.2020.17810
JAMA Patient Page

Nystagmus

Abstract Full Text
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JAMA. 2021;325(8):798. doi:10.1001/jama.2020.3911

This JAMA Patient Page describes the types, causes, and treatment of nystagmus, a rhythmic involuntary movement of the eyes.

Comment & Response

Risk of Spinal Hematoma After Lumbar Puncture

Abstract Full Text
JAMA. 2021;325(8):787. doi:10.1001/jama.2020.24595

Risk of Spinal Hematoma After Lumbar Puncture

Abstract Full Text
JAMA. 2021;325(8):787-788. doi:10.1001/jama.2020.24601

Risk of Spinal Hematoma After Lumbar Puncture—Reply

Abstract Full Text
JAMA. 2021;325(8):788. doi:10.1001/jama.2020.24607

The Effect of Surgical Treatment on Obstructive Sleep Apnea

Abstract Full Text
JAMA. 2021;325(8):788-789. doi:10.1001/jama.2020.25121

The Effect of Surgical Treatment on Obstructive Sleep Apnea—Reply

Abstract Full Text
JAMA. 2021;325(8):789-790. doi:10.1001/jama.2020.25124

Cervical Cancer Screening in Low- and Middle-Income Countries

Abstract Full Text
JAMA. 2021;325(8):790. doi:10.1001/jama.2020.25214

Cervical Cancer Screening in Low- and Middle-Income Countries—Reply

Abstract Full Text
JAMA. 2021;325(8):790-791. doi:10.1001/jama.2020.25217
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2021;325(8):705-706. doi:10.1001/jama.2020.17807
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