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January 2023 - July 1883




July 13, 2021, Vol 326, No. 2, Pages 109-196

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;326(2):e2018025. doi:10.1001/jama.2020.18025
Original Investigation

Effect of Platelet-Rich Plasma Injection vs Sham Injection on Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;326(2):137-144. doi:10.1001/jama.2021.6986

This randomized clinical trial compares the efficacy of a single injection of intratendinous platelet-rich plasma vs injection with a subcutaneous dry needle (sham) from baseline until 6-month follow-up in adult patients with chronic midportion Achilles tendinopathy.

Association Between Iatrogenic Delivery for Suspected Fetal Growth Restriction and Childhood School Outcomes

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JAMA. 2021;326(2):145-153. doi:10.1001/jama.2021.8608

This retrospective whole-population cohort study explores the association between warranted and unwarranted iatrogenic delivery for suspected fetal growth restriction and childhood school outcomes among children in Victoria, Australia.

Use of Medications for Treatment of Opioid Use Disorder Among US Medicaid Enrollees in 11 States, 2014-2018

Abstract Full Text
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JAMA. 2021;326(2):154-164. doi:10.1001/jama.2021.7374

This exploratory study examines changes in quality of care and use of medications to treat opioid use disorder from 2014 through 2018 among Medicaid patients in 11 states.

Research Letter

Payer-Negotiated Prices in the Diagnosis and Management of Thyroid Cancer in 2021

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JAMA. 2021;326(2):184-185. doi:10.1001/jama.2021.8535

This study examines price availability and variation for thyroid cancer care at National Cancer Institute (NCI)–Designated Cancer Centers following a 2021 CMS policy reform requiring hospitals to disclose commercial payer-specific negotiated prices for all items and services.

Associations of Vaccination and of Prior Infection With Positive PCR Test Results for SARS-CoV-2 in Airline Passengers Arriving in Qatar

Abstract Full Text
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JAMA. 2021;326(2):185-188. doi:10.1001/jama.2021.9970

This study explores the association of vaccination against COVID-19 or prior SARS-CoV-2 infection with PCR test positivity in airline passengers arriving in Qatar, February-April 2021.


Humanism Before Heroism in Medicine

Abstract Full Text
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JAMA. 2021;326(2):127-128. doi:10.1001/jama.2021.9569

This Viewpoint discusses the need to reframe the culture of heroic clinician narratives, particularly during the COVID-19 pandemic, and suggests that the aim should be to achieve a culture of teamwork that acknowledges the physical and emotional needs of clinicians and does not expect them to routinely sacrifice their well-being.

Progress in Pharmacotherapy for Obesity

Abstract Full Text
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JAMA. 2021;326(2):129-130. doi:10.1001/jama.2021.9486

This Viewpoint discusses the potential that newer antiobesity medications can provide for greater weight loss efficacy with an acceptable safety profile, including those with novel “twincretin” mechanisms of action.

Transforming Health Care to Address Value and Equity: National Vital Signs to Guide Vital Reforms

Abstract Full Text
JAMA. 2021;326(2):131-132. doi:10.1001/jama.2021.9938

This Viewpoint explains the national Vital Signs initiative—developed by the National Academy of Medicine to track improvements in health, health care costs, engagement of the public in its health, and health care and quality.

A Piece of My Mind

My Lie by Omission

Abstract Full Text
JAMA. 2021;326(2):133-134. doi:10.1001/jama.2021.10383

In this narrative medicine essay, a psychiatric resident who survived a suicide attempt at 16 years old aims to break the stigma against patients and peers with mental and emotional illness by sharing her story.


Delivery Before 39 Weeks’ Gestation for Suspected Fetal Growth Restriction: More Harm Than Good?

Abstract Full Text
JAMA. 2021;326(2):135-136. doi:10.1001/jama.2021.8381

Diagnosis and Treatment of Alcohol-Associated Liver Disease: A Review

Abstract Full Text
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JAMA. 2021;326(2):165-176. doi:10.1001/jama.2021.7683

This narrative review provides an update on the diagnosis and treatment of alcohol-associated liver disease, including clinical presentation, screening for alcohol use disorder, medical treatment, other treatments, and liver transplant.

JAMA Performance Improvement

Patient Safety

Rapid Response Teams as a Patient Safety Practice for Failure to Rescue

Abstract Full Text
JAMA. 2021;326(2):179-180. doi:10.1001/jama.2021.7510

This JAMA Performance Improvement article summarizes the AHRQ guideline on rapid response teams in its health care safety series, including whether rapid response teams decrease mortality or rates of cardiac arrest, if their use improves patient outcomes, and what barriers hinder their success in the hospital setting.

JAMA Insights

Women's Health

Diagnosis, Evaluation, and Treatment of Adenomyosis

Abstract Full Text
JAMA. 2021;326(2):177-178. doi:10.1001/jama.2020.26436

This JAMA Insights Clinical Update summarizes and provides a suggested treatment algorithm for the diagnosis and management of adenomyosis.

JAMA Clinical Challenge

Postoperative Skin Lesion After Knee Replacement

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JAMA. 2021;326(2):181-182. doi:10.1001/jama.2021.3832

A 71-year-old woman presented 8 weeks after total knee arthroplasty with a 1-week history of scattered tense, pruritic bullae around the incision site but no surrounding erythema or edema. She was afebrile and had no known allergies; the pruritus and bullae remained unchanged after a course of oral cephalexin and prednisone. What is the diagnosis and what would you do next?

Medical News & Perspectives

The Search for a Single Vaccine Against Coronaviruses Yet to Come

Abstract Full Text
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JAMA. 2021;326(2):118-120. doi:10.1001/jama.2021.9477

This Medical News Feature discusses the feasibility of a pancoronavirus vaccine to prevent future pandemics.

Semaglutide’s Success Could Usher in a “New Dawn” for Obesity Treatment

Abstract Full Text
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JAMA. 2021;326(2):121-123. doi:10.1001/jama.2021.10307

This Medical News article discusses the physiology of weight regulation and obesity—and how new antiobesity drugs like semaglutide will target those pathways for safer, more effective treatment.

News From the Centers for Disease Control and Prevention

Fewer COVID-19 Cases in Schools With Masks and Improved Ventilation

Abstract Full Text
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JAMA. 2021;326(2):125. doi:10.1001/jama.2021.10044

CDC Recommends Self-injected Contraceptive Option

Abstract Full Text
JAMA. 2021;326(2):125. doi:10.1001/jama.2021.10621
Biotech Innovations

Optogenetics Restores Partial Vision in a Patient With Blindness

Abstract Full Text
JAMA. 2021;326(2):124. doi:10.1001/jama.2021.10887

Potential New Blood Biomarker for Myocarditis Detection

Abstract Full Text
JAMA. 2021;326(2):124. doi:10.1001/jama.2021.10618

Artificial Intelligence in COVID-19 Imaging Mismatched to the Clinic

Abstract Full Text
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JAMA. 2021;326(2):124. doi:10.1001/jama.2021.10888
Poetry and Medicine


Abstract Full Text
JAMA. 2021;326(2):191. doi:10.1001/jama.2021.7414
JAMA Revisited

Current Comment

Abstract Full Text
JAMA. 2021;326(2):192. doi:10.1001/jama.2020.18026
JAMA Patient Page

Unhealthy Alcohol Use

Abstract Full Text
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JAMA. 2021;326(2):196. doi:10.1001/jama.2020.2015

This JAMA Patient Page defines risky alcohol use and alcohol use disorder, and describes their adverse health effects.

Comment & Response

Viewpoint on Comprehensive Medicaid Reform

Abstract Full Text
JAMA. 2021;326(2):188. doi:10.1001/jama.2021.6664

Viewpoint on Comprehensive Medicaid Reform—Reply

Abstract Full Text
JAMA. 2021;326(2):188-189. doi:10.1001/jama.2021.6667

A Review of Irritable Bowel Syndrome

Abstract Full Text
JAMA. 2021;326(2):189. doi:10.1001/jama.2021.6755

A Review of Irritable Bowel Syndrome—Reply

Abstract Full Text
JAMA. 2021;326(2):189-190. doi:10.1001/jama.2021.6758

Content Error

Abstract Full Text
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JAMA. 2021;326(2):190. doi:10.1001/jama.2021.9484

Data Errors in Table

Abstract Full Text
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JAMA. 2021;326(2):190. doi:10.1001/jama.2021.9619
JAMA Masthead


Abstract Full Text
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JAMA. 2021;326(2):109-110. doi:10.1001/jama.2020.18023