This placebo-controlled randomized clinical trial compares administration of calcium vs saline during out-of-hospital cardiac arrest for sustained return of spontaneous circulation in adults.
This study evaluates heterogeneity of treatment effect (HTE) of patent foramen ovale (PFO) closure on stroke recurrence based on the Risk of Paradoxical Embolism and PFO-Associated Stroke Causal Likelihood scoring systems using individual patient data pooled from 6 randomized clinical trials (RCTs) that compared PFO closure plus medical therapy vs medical therapy alone in patients with PFO-associated stroke.
This study of pooled data from 9 US population-based cohorts assessed mortality risk and adverse cardiovascular and respiratory outcomes for chronic lung diseases among adults with normal spirometry vs preserved ratio impaired spirometry.
This study examines rates of home dialysis and transplant at dialysis facilities that serve patients with high social risk to understand how they fare under the End-Stage Renal Disease Treatment Choices Model.
This study estimates the frequency and duration of boarding for pediatric mental health conditions at US acute care hospitals and describes hospital resources available to support youths during boarding.
This Viewpoint discusses the Food and Drug Administration granting Emergency Use Authorization of the mRNA COVID-19 vaccine BNT162b2 for children aged 5 to 11 years and the role that will play in keeping children, schools, and communities safe.
This Viewpoint cites the data collaboration during the COVID-19 pandemic as an example of unprecedented vaccine results and points to the NIH’s Policy for Data Management and Sharing to foster shared data as a routine part of grant applications.
This Viewpoint frames the clinical event risk for heart failure in the context of the approach used in the 2018 ACC/AHA cholesterol guidelines.
In this narrative medicine essay, a pediatrician who learned the hard secrets of breastfeeding after the birth of her twins shares how her experience transformed her approach to new parents by acknowledging the difficulty and helping them find support.
This narrative review summarizes current understanding of the pathophysiology, diagnosis, and management of acute appendicitis, especially comparing antibiotics-only vs surgical approaches to management.
This Guide to Statistics and Methods discusses the various approaches to estimating variability in treatment effects, including heterogeneity of treatment effect, which was used to assess the association between surgery to close patent foramen ovale and risk of recurrent stroke in patients who presented with a stroke in a related JAMA article.
A 48-year-old woman with diet-controlled diabetes had extremity arthralgias, a purpuric rash and foot paresthesias, and eye pain and redness. Vital signs and results of laboratory testing including direct immunofluorescence were unremarkable; skin biopsy showed leukocytoclasia, erythrocytic extravasation, and fibrin in small blood vessel walls. What is the diagnosis and what would you do next?
This Medical News feature examines whether it’s likely that repeated COVID-19 vaccine boosters will be needed to maintain protection against SARS-CoV-2.
This Arts and Medicine feature surveys the life and scholarship of James McCune Smith, MD, a 19th-century New York physician who cared for poor individuals, debunked pseudoscience justifying racism, and published broadly in medicine and public health.
This JAMA Patient Page describes the causes, symptoms, diagnosis, and treatment options for uncomplicated and complicated acute appendicitis.