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November 2023 - July 1883




December 28, 2021, Vol 326, No. 24, Pages 2451-2541

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;326(24):e2018289. doi:10.1001/jama.2020.18289
Original Investigation

Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;326(24):2478-2487. doi:10.1001/jama.2021.21892

This randomized clinical trial includes preterm infants with a gestational age of 25 to 28 weeks who were supported with continuous positive airway pressure and compares the effect of selective application of minimally invasive surfactant therapy at a low fraction of inspired oxygen threshold vs control treatment on survival without bronchopulmonary dysplasia.

Caring for the Critically Ill Patient

Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;326(24):2488-2497. doi:10.1001/jama.2021.22002

This multicenter randomized clinical trial assesses the effect of use of a tracheal tube introducer vs an endotracheal tube with stylet on successful intubation on the first attempt among critically ill adults undergoing tracheal intubation in emergency departments and intensive care units between 2019 and 2021.

Prevalence and Treatment of Diabetes in China, 2013-2018

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JAMA. 2021;326(24):2498-2506. doi:10.1001/jama.2021.22208

This cross-sectional nationally representative survey in China estimated trends in prevalence, awareness, treatment, and risk factors of diabetes among patients.

Research Letter

Durability of Antibody Levels After Vaccination With mRNA SARS-CoV-2 Vaccine in Individuals With or Without Prior Infection

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JAMA. 2021;326(24):2524-2526. doi:10.1001/jama.2021.19996

This study examines antibody durability in individuals who received an mRNA SARS-CoV-2 vaccine with prior SARS-CoV-2 infection vs those without infection.

Self-reported Behaviors Regarding Medications to Save Money Among Sexual Minority Adults in the US, 2015-2018

Abstract Full Text
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JAMA. 2021;326(24):2526-2529. doi:10.1001/jama.2021.20335

This survey-based study of US adults from gender and sexual minority populations examines self-reported behaviors to save money on prescription medications, including skipping doses, purchasing from other countries, delaying refills, taking less medication, and using alternative therapies.

Place of Birth of Extremely Preterm Infants in Sweden

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JAMA. 2021;326(24):2529-2530. doi:10.1001/jama.2021.21199

This study assesses rates of extremely preterm births (22-26 weeks’ gestation) and their outcomes by hospital level of care among all births registered in Sweden from 2014 to 2019.


Diagnostic Excellence

Next-Generation Artificial Intelligence for Diagnosis: From Predicting Diagnostic Labels to “Wayfinding”

Abstract Full Text
JAMA. 2021;326(24):2467-2468. doi:10.1001/jama.2021.22396

This Viewpoint explains how artificial intelligence (AI) tools have the potential to do more than predict final diagnostic labels and how AI can help reduce clinician error and more accurately diagnose and manage illness.

Product Approval and Public Health at the US Food and Drug Administration

Abstract Full Text
JAMA. 2021;326(24):2469-2470. doi:10.1001/jama.2021.22354

This Viewpoint discusses the recent FDA-proposed draft guidance on benefit-risk assessment to guide its review of new drug and biological products and how this approach will enhance its mission to protect public health.

Criterion-Based Measurements of Patient Experience in Health Care: Eliminating Winners and Losers to Create a New Moral Ethos

Abstract Full Text
JAMA. 2021;326(24):2471-2472. doi:10.1001/jama.2021.21771

This Viewpoint argues for a change in the assessment of patient experience in health care, moving from norm-based scores and rankings to a criterion-based system with transparent reporting of results.

A Piece of My Mind

How Pregnancy Unmasked My Internalized Ableism

Abstract Full Text
JAMA. 2021;326(24):2473-2474. doi:10.1001/jama.2021.22116

In this narrative medicine essay, a medical resident while pregnant fearlessly takes care of her physical needs while at work, which taught her to take a more open approach to caring for her physical needs that stem from chronic illness.


Minimally Invasive Surfactant Therapy to Prevent Bronchopulmonary Dysplasia in Extremely Preterm Infants

Abstract Full Text
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JAMA. 2021;326(24):2475-2476. doi:10.1001/jama.2021.21667

JAMA and the US Preventive Services Task Force

Abstract Full Text
JAMA. 2021;326(24):2477. doi:10.1001/jama.2021.23159

Contraception Selection, Effectiveness, and Adverse Effects: A Review

Abstract Full Text
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JAMA. 2021;326(24):2507-2518. doi:10.1001/jama.2021.21392

This Review summarizes current evidence regarding the efficacy, adverse effects, and optimal selection of reversible contraceptives, including oral contraceptive pills, intrauterine devices and subdermal implants, and condoms.

JAMA Clinical Guidelines Synopsis

Management of Gout

Abstract Full Text
JAMA. 2021;326(24):2519-2520. doi:10.1001/jama.2021.19763

This JAMA Clinical Guidelines Synopsis summarizes the American College of Rheumatology’s 2020 guideline for the management of gout.

From The Medical Letter on Drugs and Therapeutics

Two New Pneumococcal Vaccines—Prevnar 20 and Vaxneuvance

Abstract Full Text
JAMA. 2021;326(24):2521-2522. doi:10.1001/jama.2021.22119

This Medical Letter review summarizes Prevnar 20 and Vaxneuvance, 2 new pneumococcal conjugate vaccines for the prevention of invasive pneumococcal disease in adults.

Medical News & Perspectives

JAMA Network Journals’ Articles of the Year 2021

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JAMA. 2021;326(24):2456-2459. doi:10.1001/jama.2021.21479

This Medical News article is our fifth-annual roundup of the top-viewed articles from each of the JAMA Network Journals.

Omicron Has Reached the US—Here’s What Infectious Disease Experts Know About the Variant

Abstract Full Text
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JAMA. 2021;326(24):2460-2462. doi:10.1001/jama.2021.22619

This Medical News article on Omicron, the newest SARS-CoV-2 variant of concern, is adapted from a JAMA video interview recorded on December 1, 2021.

News From the Centers for Disease Control and Prevention

New Plans Focus on Health Care Workers’ Mental Health

Abstract Full Text
JAMA. 2021;326(24):2465. doi:10.1001/jama.2021.22042

Influenza Vaccination Increased During the COVID-19 Pandemic

Abstract Full Text
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JAMA. 2021;326(24):2465. doi:10.1001/jama.2021.22390
Clinical Trials Update

Semaglutide’s Weight-Loss Benefits Were Sustained in a 2-Year Study

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JAMA. 2021;326(24):2464. doi:10.1001/jama.2021.21717

More Pediatric Data for First Cell-Derived Influenza Vaccine

Abstract Full Text
JAMA. 2021;326(24):2464. doi:10.1001/jama.2021.22774

Tirzepatide Tested for Type 2 Diabetes With High Cardiovascular Risk

Abstract Full Text
JAMA. 2021;326(24):2464. doi:10.1001/jama.2021.22775

Primary Care-Delivered Cognitive Behavioral Therapy for Chronic Pain

Abstract Full Text
JAMA. 2021;326(24):2464. doi:10.1001/jama.2021.22776
Health Agencies Update

Autopsies Reveal Lung Damage Patterns From COVID-19

Abstract Full Text
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JAMA. 2021;326(24):2463. doi:10.1001/jama.2021.22070

Suicide Risk Varies With Demographics and Sexual Orientation

Abstract Full Text
JAMA. 2021;326(24):2463. doi:10.1001/jama.2021.22838

Expanding Localized Outreach to Combat COVID-19

Abstract Full Text
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JAMA. 2021;326(24):2463. doi:10.1001/jama.2021.22839
The Arts and Medicine

Graphic Medicine—The Best of 2021

Abstract Full Text
JAMA. 2021;326(24):2453-2455. doi:10.1001/jama.2021.21248

This Arts and Medicine feature reviews 2 outstanding graphic novels of 2021: Coma by Zara Slattery, about the author’s delirium while being treated for streptococcal sepsis and multiorgan failure, and Parenthesis by Élodie Durand, about her experience with tumor-induced seizures.

Poetry and Medicine


Abstract Full Text
JAMA. 2021;326(24):2537. doi:10.1001/jama.2021.19738
JAMA Revisited

Economy in Wonderland

Abstract Full Text
JAMA. 2021;326(24):2538. doi:10.1001/jama.2020.18290
JAMA Patient Page

What Is Gout?

Abstract Full Text
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JAMA. 2021;326(24):2541. doi:10.1001/jama.2021.19770

This JAMA Patient Page describes the causes, symptoms, diagnosis, and treatment of gout.

Comment & Response

Association of Cognitive Decline With Anesthesia and Surgery in Older Patients

Abstract Full Text
JAMA. 2021;326(24):2530-2531. doi:10.1001/jama.2021.20282

Association of Cognitive Decline With Anesthesia and Surgery in Older Patients—Reply

Abstract Full Text
JAMA. 2021;326(24):2531. doi:10.1001/jama.2021.20285

Crystalloid Composition and Rate of Fluid Administration When Resuscitating Patients in the Intensive Care Unit

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JAMA. 2021;326(24):2531-2532. doi:10.1001/jama.2021.20279

Crystalloid Composition and Rate of Fluid Administration When Resuscitating Patients in the Intensive Care Unit—Reply

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JAMA. 2021;326(24):2532-2533. doi:10.1001/jama.2021.20276

Private Equity and Health Care Delivery

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JAMA. 2021;326(24):2533-2534. doi:10.1001/jama.2021.20437

Private Equity and Health Care Delivery

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JAMA. 2021;326(24):2534. doi:10.1001/jama.2021.20431

Private Equity and Health Care Delivery—Reply

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JAMA. 2021;326(24):2534-2535. doi:10.1001/jama.2021.20434

Two Incorrect Sentences

Abstract Full Text
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JAMA. 2021;326(24):2535. doi:10.1001/jama.2021.21321
JAMA Masthead


Abstract Full Text
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JAMA. 2021;326(24):2451-2452. doi:10.1001/jama.2020.18287