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September 2021 - July 1883




July 27, 2021, Vol 326, No. 4, Pages 291-366

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;326(4):e2018049. doi:10.1001/jama.2020.18049
Original Investigation

Effect of a Hospital and Postdischarge Quality Improvement Intervention on Clinical Outcomes and Quality of Care for Patients With Heart Failure With Reduced Ejection Fraction: The CONNECT-HF Randomized Clinical Trial

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JAMA. 2021;326(4):314-323. doi:10.1001/jama.2021.8844

This cluster randomized trial evaluates the effect of a hospital and postdischarge quality improvement intervention vs usual care on time to heart failure rehospitalization or death, and quality of care, among patients with heart failure and reduced ejection fraction in the US.

Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial

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JAMA. 2021;326(4):324-331. doi:10.1001/jama.2021.9899

This randomized clinical trial assesses the effect of 14-day antibiotic treatment vs 7 days of antibiotic treatment plus 7 days of placebo among afebrile men with urinary tract infection.

Frequency of Thrombocytopenia and Platelet Factor 4/Heparin Antibodies in Patients With Cerebral Venous Sinus Thrombosis Prior to the COVID-19 Pandemic

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JAMA. 2021;326(4):332-338. doi:10.1001/jama.2021.9889

This retrospective analysis examined the frequency of thrombocytopenia and heparin-induced thrombocytopenia among patients with cerebral venous sinus thrombosis (CVST) before COVID-19 to help elucidate the association of ChAdOx1 nCoV-19 and Ad26.COV2.S vaccines and CVST thrombocytopenia.

Research Letter

Effect of Systemic Hydrocortisone Initiated 7 to 14 Days After Birth in Ventilated Preterm Infants on Mortality and Neurodevelopment at 2 Years’ Corrected Age: Follow-up of a Randomized Clinical Trial

Abstract Full Text
JAMA. 2021;326(4):355-357. doi:10.1001/jama.2021.9380

This follow-up to the STOP-BPD randomized clinical trial, which investigated the efficacy and safety of systemic hydrocortisone treatment initiated 7 to 14 days after birth in ventilator-dependent, very preterm infants in the Netherlands and Belgium at 36 weeks’ postmenstrual age, examines the prespecified composite of death and neurodevelopmental impairment among these infants at 2 years’ corrected age.


Lay Epidemiology and Vaccine Acceptance

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JAMA. 2021;326(4):301-302. doi:10.1001/jama.2021.11130

This Viewpoint discusses how family, friends, social media, the larger public, and others can influence an individual’s health care decisions, including COVID-19 vaccination, and offers ways in which to build confidence in vaccination among groups that may be skeptical of getting the vaccine.

COVID-19: Beyond Tomorrow

Potential COVID-19 Endgame Scenarios: Eradication, Elimination, Cohabitation, or Conflagration?

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JAMA. 2021;326(4):303-304. doi:10.1001/jama.2021.11042

This Viewpoint considers 4 possible scenarios—eradication, elimination, cohabitation, and conflagration—for the resolution of the COVID-19 pandemic, depending on vaccination rates, viral variants, and deadly disease waves.

The Growing Problem of Out-of-Pocket Costs and Affordability in Employer-Sponsored Insurance

Abstract Full Text
JAMA. 2021;326(4):305-306. doi:10.1001/jama.2021.11166

This Viewpoint describes the problem of rising out-of-pocket costs for individuals with employer-sponsored insurance, the causes of this issue, and possible solutions.

A Piece of My Mind

The Race We Already Lost

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JAMA. 2021;326(4):307-308. doi:10.1001/jama.2021.11214

In this narrative medicine essay, a resident in medicine and pediatrics learns in her last year of medical school that her physician father has metastatic liver cancer and hopes that for just a day or a little longer the 2 could share the title doctor.


Shorter Courses of Antibiotics for Urinary Tract Infection in Men

Abstract Full Text
JAMA. 2021;326(4):309-310. doi:10.1001/jama.2021.11120

Prioritizing Dissemination and Implementation Science in Cardiometabolic Medicine: CONNECTing the Dots

Abstract Full Text
JAMA. 2021;326(4):311-313. doi:10.1001/jama.2021.9847
The Rational Clinical Examination

Does This Adult Patient Have Hypertension?The Rational Clinical Examination Systematic Review

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JAMA. 2021;326(4):339-347. doi:10.1001/jama.2021.4533

This Rational Clinical Examination systematic review summarizes studies that examined the accuracy of current methods of blood pressure measurement, including home and office monitoring, compared with ambulatory blood pressure monitoring as the reference standard for diagnosing hypertension in patients not receiving treatment for hypertension.

JAMA Insights

Women's Health

Anabolic Therapy for Osteoporosis

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JAMA. 2021;326(4):350-351. doi:10.1001/jama.2021.0233

This JAMA Insights reviews the use of anabolic medications to reduce the risk of osteoporosis-related fractures, including teriparatide, abaloparatide, and romosozumab.

Lipoprotein(a) and Cardiovascular Diseases

Abstract Full Text
JAMA. 2021;326(4):352-353. doi:10.1001/jama.2021.3632

This JAMA Insights Clinical Update discusses various clinical aspects of lipoprotein(a), including association with cardiovascular disease risk, measurement, guideline recommendations, and emerging therapies.

JAMA Clinical Guidelines Synopsis

Screening for Hepatitis C Virus

Abstract Full Text
JAMA. 2021;326(4):348-349. doi:10.1001/jama.2020.27041

This JAMA Clinical Guidelines Synopsis summarizes the American Association for the Study of Liver Diseases/Infectious Diseases Society of America 2019 guideline update on screening for hepatitis C virus.

Medical News & Perspectives

Confronting High HIV Rates Among Transgender Women With Empowerment and Gender Affirmation

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JAMA. 2021;326(4):295-297. doi:10.1001/jama.2021.10598

This Medical News article describes the social and structural factors that drive exceptionally high HIV infection rates among transgender women.

News From the Centers for Disease Control and Prevention

Excess Deaths From End-Stage Kidney Disease Early in Pandemic

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JAMA. 2021;326(4):300. doi:10.1001/jama.2021.11312

Resurgence of Pertussis Linked With Switch to Acellular Vaccine

Abstract Full Text
JAMA. 2021;326(4):300. doi:10.1001/jama.2021.11153
Clinical Trials Update

Tai Chi Reduces Waist Size Among Older Adults

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JAMA. 2021;326(4):299. doi:10.1001/jama.2021.10833

MDMA-Assisted Therapy Highly Effective for PTSD

Abstract Full Text
JAMA. 2021;326(4):299. doi:10.1001/jama.2021.11748

Fewer Cardiovascular Events With Intensive Blood Pressure Control

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JAMA. 2021;326(4):299. doi:10.1001/jama.2021.11749

Filgotinib Induces and Maintains Ulcerative Colitis Remission

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JAMA. 2021;326(4):299. doi:10.1001/jama.2021.11750
Health Agencies Update

Ending Structural Racism in Federally Funded Research

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JAMA. 2021;326(4):298. doi:10.1001/jama.2021.10972

Internet Access as a Social Determinant of Health

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JAMA. 2021;326(4):298. doi:10.1001/jama.2021.11733

Higher Medicare Payments for In-home COVID-19 Vaccinations

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JAMA. 2021;326(4):298. doi:10.1001/jama.2021.11734
The Arts and Medicine

Renal Columns

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JAMA. 2021;326(4):294. doi:10.1001/jama.2021.4061

This Arts and Medicine feature contains a kidney-themed crossword puzzle.

Poetry and Medicine

Time Limits

Abstract Full Text
JAMA. 2021;326(4):361. doi:10.1001/jama.2021.8081
JAMA Revisited

Problems on Campus

Abstract Full Text
JAMA. 2021;326(4):362. doi:10.1001/jama.2020.18050
JAMA Patient Page

Cardiac Rehabilitation

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JAMA. 2021;326(4):366. doi:10.1001/jama.2021.5952

This JAMA Patient Page describes the goals of cardiac rehabilitation, its 3 phases, and which patients benefit from it.

Comment & Response

Effect of Ventral vs Dorsal Spinal Surgery in Patients With Cervical Spondylotic Myelopathy

Abstract Full Text
JAMA. 2021;326(4):357-358. doi:10.1001/jama.2021.7262

Effect of Ventral vs Dorsal Spinal Surgery in Patients With Cervical Spondylotic Myelopathy

Abstract Full Text
JAMA. 2021;326(4):358. doi:10.1001/jama.2021.7265

Effect of Ventral vs Dorsal Spinal Surgery in Patients With Cervical Spondylotic Myelopathy—Reply

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JAMA. 2021;326(4):358-359. doi:10.1001/jama.2021.7268

Blinatumomab vs Chemotherapy Among Children With Relapsed Acute Lymphoblastic Leukemia

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JAMA. 2021;326(4):359. doi:10.1001/jama.2021.8151

Blinatumomab vs Chemotherapy Among Children With Relapsed Acute Lymphoblastic Leukemia—Reply

Abstract Full Text
JAMA. 2021;326(4):359-360. doi:10.1001/jama.2021.8154

Incorrect Figure

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JAMA. 2021;326(4):360. doi:10.1001/jama.2021.9741
JAMA Masthead


Abstract Full Text
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JAMA. 2021;326(4):291-292. doi:10.1001/jama.2020.18047