This randomized clinical trial compares the effect of a balanced solution vs saline solution on 90-day survival in critically ill patients.
This factorial clinical trial examined whether infusing critically ill patients in the intensive care unit requiring fluid challenges at a slower rate than a faster rate would reduce 90-day mortality.
This randomized clinical trial compares use of a school-wide integrated pest management (IPM) program vs use of high-efficiency particulate air (HEPA) filter purifiers in the classrooms for students with active asthma attending urban elementary schools who were randomized to IPM by school and HEPA filter purifiers by classroom.
This study examines the relationship between age and neutralizing antibody titers against the SARS-CoV-2 USA-WA1/2020 strain and the P.1 variant after 2 doses of the BNT162b2 vaccine.
This cohort study reports the prevalence of long-term symptoms in children and adolescents who had recovered from acute SARS-CoV-2 infection.
This Viewpoint suggests a hybrid reimbursement model for primary care practices that could help align payments and practice structure with the types and intensity of services that patients need.
This Viewpoint revisits the Open Payments Program, mandated by the Sunshine Act, and discusses alleged violations by device and pharmaceutical manufacturers and the future enforcement of the program.
This Viewpoint discusses the mission, vision, and goals of the US National Cancer Institute Center for Global Health on the 10th anniversary of creation of the Center, which was established to incorporate cancer control into broader global health programs, foster relevant research, and cultivate collaborations among researchers with shared global health objectives.
In this narrative medicine essay, a geriatrician describes how his mother and he navigate the last months and days of her life while basking in their mutual love, trust, and respect.
This review summarizes current evidence regarding pathobiology, diagnosis, and management of pancreatic ductal adenocarcinoma.
This JAMA Insights article reviews how changes in the brain related to aging may contribute to decreased cognitive reserve, susceptibility to the stresses of surgery and anesthesia, and increased risk of neurologic injury from anesthesia and surgery in older patients.
A 47-year-old man with melanoma presented with 1 week of low-grade fevers, myalgias, elevated creatine kinase levels, and proximal muscle weakness. He previously underwent amputation of a finger and began adjuvant nivolumab for stage IIIC melanoma. One week later, he developed fevers, myalgias, dark urine, weakness, and difficulty walking. What is the diagnosis and what would you do next?
This Medical News article discusses new American Academy of Pediatrics policy that advises universal cardiac screening for children and adolescents.
This Arts and Medicine feature reviews currently available medical emoji and proposes that an expanded set of images could improve medical communication, clinical care, and public health.
This JAMA Patient Page explains what virus variants are and describes several recent variants of the SARS-CoV-2 virus and the public health concerns relating to these variants.