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Year

Day

January 15, 2021
JAMA Clinical Challenge

An 18-Month History of Dorsal Foot Lesions

Abstract Full Text
has active quiz
JAMA. Published online January 15, 2021. doi:10.1001/jama.2020.16053

A 32-year-old Nigerian woman with a childhood transfusion history developed scaly plaques with cobblestone surfaces on the dorsum of the forefoot and midfoot bilaterally; serologic testing was negative for HIV and positive for hepatitis C virus. What is the diagnosis and what would you do next?

January 14, 2021
Viewpoint

Funding of Pharmaceutical Innovation During and After the COVID-19 Pandemic

Abstract Full Text
free access
JAMA. Published online January 14, 2021. doi:10.1001/jama.2020.25384

This Viewpoint considers whether the shift away from private investment toward government funding of drug and vaccine development and commercialization during the coronavirus disease 2019 (COVID-19) pandemic is sustainable, arguing that the same or greater level of public investment will be necessary if drug prices are to remain affordable and if the US wants to maintain its global leadership position.

JAMA Diagnostic Test Interpretation

APOE ɛ4 Allele Testing and Risk of Alzheimer Disease

Abstract Full Text
has active quiz
JAMA. Published online January 14, 2021. doi:10.1001/jama.2020.15085

A 64-year-old man underwent APOE ɛ4 allele testing for 3 years of forgetfulness and word-finding difficulties and a family history of early-onset dementia, with results positive for genotypes 3 and 4 indicating “with high specificity, that Alzheimer’s disease is the cause of or a contributor to the observed dementia.” What would you do next?

January 13, 2021
Viewpoint

Problematic Promotion of Medications by Nurse Ambassadors—Legal and Ethical Issues

Abstract Full Text
free access
JAMA. Published online January 13, 2021. doi:10.1001/jama.2020.24509

This Viewpoint explains how pharmaceutical companies use “nurse ambassadors,” paid registered nurses who interact with patients in home or phone visits to facilitate provision, administration, and refills of expensive medication, and implications of a 2020 settlement between AbbVie and the state of California requiring improved disclosures but largely allowing the programs to continue.

Medical News & Perspectives

Therapists Donate Their Time to Counsel Distressed Health Care Workers

Abstract Full Text
free access has active quiz
JAMA. Published online January 13, 2021. doi:10.1001/jama.2020.25689

This Medical News article describes organizations that have recruited therapists to offer free or discounted mental health services to health care workers during the COVID-19 pandemic.

January 11, 2021
Original Investigation

Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis: The APPAC II Randomized Clinical Trial

Abstract Full Text
free access has audio
JAMA. Published online January 11, 2021. doi:10.1001/jama.2020.23525

This noninferiority trial compares the effects of 2 antibiotic strategies, oral moxifloxacin vs intravenous ertapenem followed by oral levofloxacin, on hospital discharge without surgery and recurrent appendicitis over 1 year among adults presenting to the emergency department with uncomplicated acute appendicitis.

Editorial

Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis

Abstract Full Text
free access
JAMA. Published online January 11, 2021. doi:10.1001/jama.2020.23607
January 8, 2021
Viewpoint

Balancing the Risks and Benefits of Benzodiazepines

Abstract Full Text
free access
JAMA. Published online January 8, 2021. doi:10.1001/jama.2020.22106

Following a September 2020 FDA announcement of a boxed warning for benzodiazepines, this Viewpoint reviews the relative benefits and risks of the drugs to reduce overuse in at-risk patients, moderate underuse in clinically appropriate instances, and guide judicious, rational prescribing.

Three Interventions to Address the Other Pandemic—Firearm Injury and Death

Abstract Full Text
free access
JAMA. Published online January 8, 2021. doi:10.1001/jama.2020.24206

This Viewpoint reviews 3 policy options with broad political support that have been shown or are being studied to reduce gun violence: mapping sites for individuals to temporarily store their firearms during a crisis, voluntary do-not-sell lists, and extreme risk protection orders to restrict firearm purchase and possession by individuals at high risk of harm.

January 7, 2021
Viewpoint

Obesity Management in Women of Reproductive Age

Abstract Full Text
free access
JAMA. Published online January 7, 2021. doi:10.1001/jama.2020.21096

This Viewpoint summarizes obstetric complications of overweight and obesity, including adverse pregnancy outcomes, gestational diabetes, and hypertensive disorders, and reviews weight management options available to patients and their treating physicians.

JAMA Clinical Challenge

Scaly Dermatitis and Edema in an Irritable Child

Abstract Full Text
has active quiz
JAMA. Published online January 7, 2021. doi:10.1001/jama.2020.10429

A 19-month-old boy fed a vegan diet after being diagnosed with milk, egg, and peanut allergies developed failure to thrive, speech delay, and acute irritability with widespread dermatitis and edema. What is the diagnosis and what would you do next?

January 6, 2021
Viewpoint

Problems With Paying People to Be Vaccinated Against COVID-19

Abstract Full Text
free access has active quiz
JAMA. Published online January 6, 2021. doi:10.1001/jama.2020.27121

This Viewpoint describes features of 2 proposals to pay US residents to be vaccinated against COVID-19 and proposes ethical and practical complications of the plans, arguing that they are morally suspect, likely unnecessary, and may be counterproductive.

Genetic Variants of SARS-CoV-2—What Do They Mean?

Abstract Full Text
free access has active quiz has audio
JAMA. Published online January 6, 2021. doi:10.1001/jama.2020.27124

This Viewpoint discusses emerging genetic variants of SARS-CoV-2, including new “UK” and “mink” variants and the significance of the new variants to coronavirus transmissibility, spread, virulence, and efforts to vaccinate the population against COVID-19.

Medical News & Perspectives

Quick Uptakes

Sorting Out Whether Vitamin D Deficiency Raises COVID-19 Risk

Abstract Full Text
free access has active quiz
JAMA. Published online January 6, 2021. doi:10.1001/jama.2020.24127

This Medical News Quick Uptake examines the debate about a link between vitamin D and COVID-19 risk.

Africa Succeeded Against COVID-19’s First Wave, but the Second Wave Brings New Challenges

Abstract Full Text
free access has active quiz
JAMA. Published online January 6, 2021. doi:10.1001/jama.2020.24288

This Medical News article discusses how Africa prevailed during the early onslaught of coronavirus disease 2019 and made plans to combat a second wave of the pandemic.

January 4, 2021
Research Letter

Changes in Abortion in Texas Following an Executive Order Ban During the Coronavirus Pandemic

Abstract Full Text
free access has active quiz
JAMA. Published online January 4, 2021. doi:10.1001/jama.2020.24096

This study assesses changes in abortions performed and at what gestational age following a Texas order postponing nonmedically necessary surgeries due to the COVID-19 pandemic compared with abortions performed during the same months in 2019.

Viewpoint

Public Health Messaging in an Era of Social Media

Abstract Full Text
free access has active quiz
JAMA. Published online January 4, 2021. doi:10.1001/jama.2020.24514

This Viewpoint discusses the rapid spread of scientific misinformation on social media platforms throughout the COVID-19 pandemic and proposes strategies to counteract its adverse effects including surveillance of digital data and partnering with trusted messengers to engage the public and advance scientifically sound public health measures.

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