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A 32-year-old Nigerian woman with a childhood transfusion history developed scaly plaques with cobblestone surfaces on the dorsum of the forefoot and midfoot bilaterally; serologic testing was negative for HIV and positive for hepatitis C virus. What is the diagnosis and what would you do next?

This Viewpoint considers whether the shift away from private investment toward government funding of drug and vaccine development and commercialization during the coronavirus disease 2019 (COVID-19) pandemic is sustainable, arguing that the same or greater level of public investment will be necessary if drug prices are to remain affordable and if the US wants to maintain its global leadership position.

A 64-year-old man underwent APOE ɛ4 allele testing for 3 years of forgetfulness and word-finding difficulties and a family history of early-onset dementia, with results positive for genotypes 3 and 4 indicating “with high specificity, that Alzheimer’s disease is the cause of or a contributor to the observed dementia.” What would you do next?

This Viewpoint explains how pharmaceutical companies use “nurse ambassadors,” paid registered nurses who interact with patients in home or phone visits to facilitate provision, administration, and refills of expensive medication, and implications of a 2020 settlement between AbbVie and the state of California requiring improved disclosures but largely allowing the programs to continue.

This Medical News article describes organizations that have recruited therapists to offer free or discounted mental health services to health care workers during the COVID-19 pandemic.

This noninferiority trial compares the effects of 2 antibiotic strategies, oral moxifloxacin vs intravenous ertapenem followed by oral levofloxacin, on hospital discharge without surgery and recurrent appendicitis over 1 year among adults presenting to the emergency department with uncomplicated acute appendicitis.

Following a September 2020 FDA announcement of a boxed warning for benzodiazepines, this Viewpoint reviews the relative benefits and risks of the drugs to reduce overuse in at-risk patients, moderate underuse in clinically appropriate instances, and guide judicious, rational prescribing.

This Viewpoint reviews 3 policy options with broad political support that have been shown or are being studied to reduce gun violence: mapping sites for individuals to temporarily store their firearms during a crisis, voluntary do-not-sell lists, and extreme risk protection orders to restrict firearm purchase and possession by individuals at high risk of harm.

This Viewpoint summarizes obstetric complications of overweight and obesity, including adverse pregnancy outcomes, gestational diabetes, and hypertensive disorders, and reviews weight management options available to patients and their treating physicians.

A 19-month-old boy fed a vegan diet after being diagnosed with milk, egg, and peanut allergies developed failure to thrive, speech delay, and acute irritability with widespread dermatitis and edema. What is the diagnosis and what would you do next?

This Viewpoint describes features of 2 proposals to pay US residents to be vaccinated against COVID-19 and proposes ethical and practical complications of the plans, arguing that they are morally suspect, likely unnecessary, and may be counterproductive.

This Viewpoint discusses emerging genetic variants of SARS-CoV-2, including new “UK” and “mink” variants and the significance of the new variants to coronavirus transmissibility, spread, virulence, and efforts to vaccinate the population against COVID-19.

This Medical News Quick Uptake examines the debate about a link between vitamin D and COVID-19 risk.

This Medical News article discusses how Africa prevailed during the early onslaught of coronavirus disease 2019 and made plans to combat a second wave of the pandemic.

This study assesses changes in abortions performed and at what gestational age following a Texas order postponing nonmedically necessary surgeries due to the COVID-19 pandemic compared with abortions performed during the same months in 2019.

This Viewpoint discusses the rapid spread of scientific misinformation on social media platforms throughout the COVID-19 pandemic and proposes strategies to counteract its adverse effects including surveillance of digital data and partnering with trusted messengers to engage the public and advance scientifically sound public health measures.