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Year

Day

October 26, 2020
Viewpoint

Preventing the Spread of SARS-CoV-2 With Masks and Other “Low-tech” Interventions

Abstract Full Text
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JAMA. Published online October 26, 2020. doi:10.1001/jama.2020.21946

In this Viewpoint, Anthony Fauci and colleagues at NIAID emphasize the continued importance of low-tech public health practices, such as wearing masks, limiting large gatherings, hand washing, and physical distancing, to help control the COVID-19 pandemic even after safe and effective vaccines become available until distribution and uptake of vaccines confer herd immunity on a population level.

Expanding Use of Clinical Genome Sequencing and the Need for More Data on Implementation

Abstract Full Text
free access has audio
JAMA. Published online October 26, 2020. doi:10.1001/jama.2020.19933

This Viewpoint discusses the importance of understanding how next-generation genomic sequencing is being implemented—for whom noninvasive prenatal testing, whole-exome and -genome sequencing for suspected genetic disorders, and tumor sequencing is being used and who is paying for it—as precondition for knowing how the technologies can best serve patients.

October 23, 2020
Original Investigation

Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA. Published online October 23, 2020. doi:10.1001/jama.2020.18618

This randomized clinical trial compares the effect of regional citrate vs systemic heparin anticoagulation on dialysis filter life span and 90-day mortality among critically ill adults with acute kidney injury (AKI) receiving continuous kidney replacement therapy.

October 22, 2020
Viewpoint

Scientific and Ethical Principles Underlying Recommendations From the Advisory Committee on Immunization Practices for COVID-19 Vaccination Implementation

Abstract Full Text
free access has active quiz
JAMA. Published online October 22, 2020. doi:10.1001/jama.2020.20847

This Viewpoint summarizes the principles guiding coronavirus disease 2019 (COVID-19) vaccine recommendations made by the Advisory Committee on Immunization Practices (ACIP), a nongovernment advisory standing committee that counsels the Centers for Disease Control and Prevention on US population vaccine use, emphasizing that any final recommendations await phase 3 safety and efficacy data from ongoing trials.

JAMA Clinical Challenge

Dyschromic Nails, Exertional Dyspnea, and Lower Extremity Edema

Abstract Full Text
has active quiz
JAMA. Published online October 22, 2020. doi:10.1001/jama.2020.14648

A 70-year-old man with a 2-year history of nasal congestion, rhinorrhea, and chronic cough developed yellow discoloration and thickening of his fingernails and toenails and progressive exertional dyspnea and edema of both lower extremities. ANA was positive (1:160, nucleolar pattern), a chest radiograph was unrevealing, and sinus CT showed bilateral maxillary and posterior ethmoidal sinusitis. What is the diagnosis and what would you do next?

October 21, 2020
Medical News & Perspectives

The Challenges of Expanding Rapid Tests to Curb COVID-19

Abstract Full Text
free access has active quiz
JAMA. Published online October 21, 2020. doi:10.1001/jama.2020.21106

This Medical News feature examines the debate about the value of frequent testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

October 19, 2020
JAMA Insights

Herd Immunity and Implications for SARS-CoV-2 Control

Abstract Full Text
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JAMA. Published online October 19, 2020. doi:10.1001/jama.2020.20892

This JAMA Insights Clinical Update discusses herd immunity in the context of the COVID-19 pandemic and explains the herd immunity threshold as a function of transmissibility (R0), the role of an effective vaccine and vaccination program in sustaining herd immunity, and the risks of an infection-based herd immunity approach.

JAMA Patient Page

What Is Herd Immunity?

Abstract Full Text
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JAMA. Published online October 19, 2020. doi:10.1001/jama.2020.20895

This JAMA Patient Page describes what herd immunity is, how it limits disease spread, and how it is achieved in a population either by vaccination or by infection and recovery from a disease.

October 16, 2020
Viewpoint

Answering Key Questions About COVID-19 Vaccines

Abstract Full Text
free access has active quiz
JAMA. Published online October 16, 2020. doi:10.1001/jama.2020.20590

This Viewpoint offers provisional answers to common questions the public will have about approved COVID-19 vaccines, including what they can expect regarding its effectiveness and safety, trustworthiness of the approval process, and whether society can return to normal once sufficient numbers of people are immunized.

Postlicensure Evaluation of COVID-19 Vaccines

Abstract Full Text
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JAMA. Published online October 16, 2020. doi:10.1001/jama.2020.19328

This Viewpoint explains the “test-negative” modified case-control design commonly used for evaluating vaccine effectiveness, describes why it may be lead to biased estimates of COVID-19 vaccine effectiveness in patients with severe illness more likely to test negative, and proposes potential approaches to correcting the bias, including incorporation of clinical assessment of cases.

Postapproval Vaccine Safety Surveillance for COVID-19 Vaccines in the US

Abstract Full Text
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JAMA. Published online October 16, 2020. doi:10.1001/jama.2020.19692

This Viewpoint reviews systems in place to monitor postlicensure vaccine safety, and recommends harmonizing end points and protocols across vaccine trials and surveillance systems to enable timely identification and reliable evaluation of potential adverse events.

October 15, 2020
Viewpoint

Sensible Medicine—Balancing Intervention and Inaction During the COVID-19 Pandemic

Abstract Full Text
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JAMA. Published online October 15, 2020. doi:10.1001/jama.2020.20271

This Viewpoint discusses the tensions between rapid adoption of interventions for coronavirus disease 2019 (COVID-19) before adequate evidence justifies their use and therapeutic nihilism, and argues for sensible medicine between the 2, which favors usual care, disfavors unnecessary interventions, but embraces rapid scientific evaluation with clinical translation of options proven effective.

Medical News & Perspectives

Large Meta-analysis Digs Into Obesity’s COVID-19 Risks

Abstract Full Text
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JAMA. Published online October 15, 2020. doi:10.1001/jama.2020.18637

This Medical News article is an interview with nutrition expert Barry Popkin, PhD, lead author of a new systematic review and meta-analysis of studies on coronavirus disease 2019 among individuals who are obese.

October 14, 2020
Special Communication

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society–USA Panel

Abstract Full Text
free access
JAMA. Published online October 14, 2020. doi:10.1001/jama.2020.17025

This guideline from the International Antiviral (formerly AIDS) Society–USA updates practice recommendations for managing HIV infection including when to initiate antiviral therapy, how to monitor patients’ response, when to change antiviral regimens, and use of preexposure prophylaxis (PrEP) to prevent infection in those at risk.

Viewpoint

Is It Lawful and Ethical to Prioritize Racial Minorities for COVID-19 Vaccines?

Abstract Full Text
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JAMA. Published online October 14, 2020. doi:10.1001/jama.2020.20571

This Viewpoint considers how COVID-19 vaccines can be distributed strategically, ethically, and legally given conflicts between consensus public health recommendations to prioritize allocation to disadvantaged racial and ethnic minorities and laws discouraging explicit consideration of race in policy decisions.

October 12, 2020
Research Letter

COVID-19 and Excess All-Cause Mortality in the US and 18 Comparison Countries

Abstract Full Text
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JAMA. Published online October 12, 2020. doi:10.1001/jama.2020.20717

This Viewpoint compares the COVID-19 per capita overall and excess mortality rates in the US vs that of 18 OECD countries and the timing of any increases in excess mortality between February and September 2020.

October 9, 2020
Viewpoint

Confronting State Medicaid Drug Spending Pressures

Abstract Full Text
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JAMA. Published online October 9, 2020. doi:10.1001/jama.2020.19325

In the context of declining state Medicaid revenues and rising enrollment related due to coronavirus disease 2019, this Viewpoint proposes policy and payment reforms related to mandated drug coverage and manufacturer rebates that could assist states financially while maintaining patient access to life-saving medications.

JAMA Clinical Challenge

Headache, Confusion, and Somnolence in a 27-Year-Old Woman

Abstract Full Text
has active quiz
JAMA. Published online October 9, 2020. doi:10.1001/jama.2020.10167

A woman who had immigrated from Guatemala 1 year prior developed headache, photophobia, vomiting, somnolence, and confusion but no focal neurologic deficits. Brain CT showed ventriculomegaly, hydrocephalus, and cerebral edema, while brain MRI showed a nonenhancing lesion obstructing the aqueduct of Sylvius that moved to the fourth ventricle with hydrocephalus resolution on repeat imaging 5 days later. What is the diagnosis and what would you do next?

October 8, 2020
Viewpoint

Heritable Human Genome Editing: The International Commission Report

Abstract Full Text
free access
JAMA. Published online October 8, 2020. doi:10.1001/jama.2020.19059

This Viewpoint summarizes the report of the International Commission on the Clinical Use of Human Germline Genome Editing sponsored by the US National Academy of Medicine and the UK Royal Society, enumerating technical, regulatory, and ethical standards that need to be met before HHGE can be used on human embryos.

COVID-19: Beyond Tomorrow

Pandemic-Driven Posttraumatic Growth for Organizations and Individuals

Abstract Full Text
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JAMA. Published online October 8, 2020. doi:10.1001/jama.2020.20275

This Viewpoint discusses how disruptions from the coronavirus disease 2019 (COVID-19) pandemic can set the stage for beneficial personal and organizational change, and proposes steps that can be taken to catalyze the posttraumatic growth process.

October 7, 2020
Viewpoint

A National Commitment to Improve the Care of Patients With Hypertension in the US

Abstract Full Text
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JAMA. Published online October 7, 2020. doi:10.1001/jama.2020.20356

This Viewpoint from the US Surgeon General’s office announces the 2020 release of the Surgeon General’s Call to Action to Control Hypertension and summarizes its key goals and recommendations aimed at making hypertension control a national public health priority and ensuring communities and patients have the resources to achieve it.

Medical News & Perspectives

Telephone Visits Surge During the Pandemic, but Will They Last?

Abstract Full Text
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JAMA. Published online October 7, 2020. doi:10.1001/jama.2020.17201

This Medical News article describes the use of telephone visits to deliver care during the pandemic.

October 5, 2020
Viewpoint

Long-term Health Consequences of COVID-19

Abstract Full Text
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JAMA. Published online October 5, 2020. doi:10.1001/jama.2020.19719

This Viewpoint discusses the long-term symptoms and sequelae of COVID-19 infection, including physical manifestations and mental health consequences, and calls for observational studies and clinical trials to better understand the disease after the acute phase.

COVID-19: Beyond Tomorrow

Preserving Elective Surgeries in the COVID-19 Pandemic and the Future

Abstract Full Text
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JAMA. Published online October 5, 2020. doi:10.1001/jama.2020.19594

This Viewpoint describes the temporary halting of elective surgery as a consequence of the COVID-19 pandemic and discusses the implications of it that may inform future approaches during crisis and uncertainty.

October 2, 2020
Viewpoint

De-adopting Low-Value Care: Evidence, Eminence, and Economics

Abstract Full Text
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JAMA. Published online October 2, 2020. doi:10.1001/jama.2020.17534

This Viewpoint proposes that varying combinations of evidence, physician influence, and economics guide the continuation or de-adoption of low-value health services and can help organize and prioritize policy initiatives to drive down the prevalence of wasteful care.

From The Medical Letter on Drugs and Therapeutics

Influenza Vaccine for 2020-2021

Abstract Full Text
free access
JAMA. Published online October 2, 2020. doi:10.1001/jama.2020.19507

This Medical Letter review summarizes available influenza vaccine formulations for use during the 2020-2021 flu season, with guidance on which to choose for specific age groups and populations.

October 1, 2020
Viewpoint

Nutrient Warnings on Unhealthy Foods

Abstract Full Text
free access
JAMA. Published online October 1, 2020. doi:10.1001/jama.2020.18941

This Viewpoint argues for inclusion of simply worded nutrition warnings on foods with excessive levels of sugar, sodium, and saturated fat, discussing international experience with the practice and its potential to incentivize healthier food products and reduce health inequities.

JAMA Patient Page

Risk of COVID-19 During Air Travel

Abstract Full Text
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JAMA. Published online October 1, 2020. doi:10.1001/jama.2020.19108

This JAMA Patient Page describes the risk of acquiring the COVID-19 virus associated with air travel, steps that airlines and airports are taking to mitigate risk, and steps that passengers can take to reduce their risk.

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