In this Viewpoint, the author discusses the need for studying treatments that help patients with persistent depression.
This Viewpoint discusses the barriers to physicians’ seeking treatment for depression, burnout, and suicide ideation; reviews the pros and cons of establishing a mental health screening protocol for physicans; and calls for research on the effect screening has on mental health outcomes.
In this Viewpoint, Gostin and colleagues review recommendations developed by experts convened by Georgetown University on how the international community can respond to the 2018 Ebola outbreak in the Democratic Republic of Congo (DRC) in the midst of active conflict and insecurity from armed rebels.
This Viewpoint discusses ways in which vendors of electronic health record (EHR) systems can block the conduct and dissemination of EHR usability and safety research and calls for policies that promote the identification and communication of usability and safety issues.
A man in his 30s had a 5-day history of fever, rhinorrhea, nonproductive cough, fever, and a maculopapular rash on his neck and trunk that spread to the extremities. He had leukopenia, and liver enzyme levels were elevated. What would you do next?
This Medical News & Perspectives article discusses recently enacted state laws that allow prescribed opioids to be substituted with medical marijuana.
This Viewpoint calls out the limited evidence supporting current pay-for-improvement incentives in the US, and argues that performance improvement programs that emphasize nonfinancial rewards, resources for quality improvement, and team-based recognition would be more consistent with physician motivation and professionalism and would be worth evaluating as a means to reduce health care costs and waste and improve quality.
This JAMA Clinical Guidelines Synopsis summarizes the 2017 practice guidance from the American Association for the Study of Liver Diseases on diagnosis and management of nonalcoholic fatty liver disease.
This Medical News article examines the ongoing debate about whether people should begin getting immunized against influenza as soon as the vaccine becomes available.
This Viewpoint discusses the spread of scientific misinformation through social media, and countermeasures scientists and institutions can use to monitor and respond to it.
A 36-year-old gravida 3, para 3 woman who had elective cesarean delivery 11 days prior presented with 3 days of exertional chest pain, an elevated troponin I level, ST-segment depression on electrocardiography, and coronary artery dissection on angiography. What would you do next?
In this Viewpoint, the authors review Medicare & Medicaid Services 340B Payment program and recent rules to curtail expansion of drug discounts beyond serving poor patients.
Following esophageal resection for cancer, a 73-year-old man was admitted to the ICU with pneumonia and progressive acute respiratory failure, and he was placed on mechanical ventilation. At day 5, his creatinine level continued to increase. How would you proceed?
In this Viewpoint, Eric Topol and Lionel Tarrasenko, a biomedical engineer known for developing early-warning systems in critical care settings, contrast the precision monitoring of jet engines with existing monitoring systems in patients, and discuss how sensors, artificial intelligence, and other contemporary digital technologies used to monitor the maintenance needs of engines can be used to personalize treatment and improve outcomes for patients without generating false alarms.
This Viewpoint discusses strategies for debunking health misinformation on social media and ideas for ways to spread accurate health information.
This Viewpoint discusses recent problems with undisclosed conflicts of interest and proposes broadening disclosure requirements beyond individuals to include the institutions funding the research.
This randomized clinical trial compares the effects of a program combining transition and long-term self-management support vs transition support alone on 6-month hospitalizations and emergency department visits among patients with chronic obstructive pulmonary disease (COPD).
This randomized clinical trial compares the effects of the dipeptidyl peptidase 4 inhibitor linagliptin vs placebo plus usual care on cardiovascular (CV) and renal outcomes in adults with type 2 diabetes and high CV and renal risk.
This Viewpoint highlights logistical and methodological challenges complicating the use of randomized clinical trials (RCTs) to evaluate medical procedures and proposes standards of evidence for adopting new procedures in the absence of RCT data, including use of observational surveillance data to confirm the procedures’ effectiveness in real-world settings.
This Clinical Evidence Synopsis summarizes a Cochrane review of randomized trials comparing the effects of treatment of lower extremity superficial thrombophlebitis on venous thromboembolism and major bleeding.
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