reviews the rationale for intention-to-treat (ITT) analyses of randomized trials, explains how commonly used alternatives reintroduce confounding that randomization is intended to eliminate, and emphasizes that even an ITT analysis is no substitute for informed scientific and clinical judgement when interpreting trial results.
This JAMA Clinical Guidelines Synopsis summarizes the 2017 clinical practice guidance from the US Department of Veterans Affairs/US Department of Defense on management of posttraumatic stress disorder and acute stress disorder.
In this Viewpoint, Sandro Galea acknowledges reasons physicians have traditionally been hesitant to speak out publicly on matters of politics and public health, and reviews how shifting roles and means of communication are forcing practitioners to reconsider that hesitancy and engage in controversies of public health concern, such as gun violence.
This Medical News story is an interview with Megan Ranney, MD, MPH, one of the leading voices in the “This Is Our Lane” movement, which discusses the role of physicians and other health-care professionals in addressing firearm violence as a public health issue.
This Viewpoint discusses new fee-for-service billing codes introduced by CMS for reimbursement of virtual care including e-consults, remote physiologic monitoring, and video and image review, and proposes strategies to incentivize the activities to promote coordinated care.
A 55-year-old man with several weeks of malaise, a 6.8-kg weight loss, a CT scan with multifocal liver masses and elevated alkaline phosphatase, ALT, and AFP levels had a heterogeneously enhancing pancreatic-tail mass on triple-phase CT. What would you do next?
This Medical News article is an interview with Denis Mukwege, MD, cowinner of the 2018 Nobel Peace Prize.
In this Medical News & Perspectives article, experts discuss how physicians deal with increasing black lung disease cases among Appalachian miners, many at younger ages than in the past.
In this Viewpoint, Abraham Verghese and Sonoo Thadaney Israni acknowledge the promise of artificial intelligence (AI) for health care, but argue that developers must work with physicians to ensure that any AI health care system helps clinicians deliver better, more equitable humanistic care, not just more accurate, scientific care.
This Viewpoint discusses questions that should be addressed to successfully integrate artificial intelligence into clinical care.
This Viewpoint discusses the practice of using a clock timer analogy to describe population risks of cancer and suggests standardizing the measures of incidence rates used in the clocks to population size to facilitate more accurate comparisons between populations.
This Viewpoint discusses free or reduced tuition programs for medical students and the implications for diversifying the health care workforce, filling shortages in primary care specialties, improving patient access, closing the health disparities gap, and improving population health.
In this Viewpoint, Howard Koh and colleagues discuss the value the public places on corporations that actively promote community health and environmental responsibility, and innovative business strategies that some corporations have implemented to advance consumer, employee, community, and environmental health.
This Viewpoint reviews the benefits and risks of risk-reducing mastectomy in otherwise healthy women with BRCA1 and BRCA2 mutations to inform discussions about the proceeding with or foregoing the procedure, and it calls for continued research to understand how to better individualize risk and prevent disease nonsurgically.
This Medical News & Perspectives story examines the debate over whether opting for whole-fat dairy or nonfat dairy or avoiding dairy altogether is optimal for health.
This Medical News article is an interview with the director of the National Institute of Child Health and Human Development about its Human Placenta Project.
This Viewpoint examines the 2018 Nuffield Council on Bioethics report on the social and ethical issues of heritable genome editing, and discusses the report’s rejection of the notion of genomic essentialism.
A 68-year-old woman with chronic lymphocytic leukemia (CLL) presents with dyspnea on exertion, conjunctival pallor and scleral icterus, and moderate anemia with elevated reticulocytes and LDH and a 3+ anti-IgG direct antiglobulin test (DAT). How do you interpret the results?
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