This systematic review and meta-analysis assesses the effects of long-acting muscarinic antagonist vs placebo or vs other controllers as an add-on therapy to inhaled corticosteroids and the use of triple therapy vs inhaled corticosteroids and long-acting β-agonists in patients with uncontrolled, persistent asthma.
This systematic review and meta-analysis of randomized trials compares the efficacy of combined use of inhaled corticosteroids and long-acting β-agonists (LABAs) as the controller and the quick relief therapy (SMART) vs the same or higher doses of inhaled corticosteroids with or without a LABA used as the controller therapy and short-acting β-agonists as the relief therapy in patients with persistent asthma.
This JAMA Clinical Guidelines Synopsis summarizes the 2018 Endocrine Society guideline on testosterone therapy in men with testosterone deficiency and hypogonadism..
This Viewpoint summarizes a 2017 NASEM Roundtable on Genomics and Precision Health that shared experiences of US health systems with use of genome sequencing for clinical and research applications and that explored how the sequencing programs might advance models for data sharing and collaborative implementation research; generate evidence regarding the benefits, harms, and value of precision medicine; and reduce disparities through partnerships with diverse populations.
This Viewpoint compares and contrasts recommendations from the 2017 ADA and ACC/AHA guidelines for management of high blood pressure and argues for individualization of patient goals and blood pressure targets.
In this Viewpoint, authors from the Vatican, academic medicine, and climate sciences highlight areas of consensus about climate change in their respective health, science, and faith communities and call for global collaboration to mitigate its effects, reduce health disparities, and improve human health.
This Medical News story discusses clinical approaches in the treatment of gout.
In this Medical News story, researchers discuss an experimental device that uses a novel approach to relieve symptoms of somatic tinnitus.
This Viewpoint discusses how newer technologies such as machine learning and the compilation of “big data” can be used for research and clinical applications.
This Viewpoint highlights the inadequacy and lack of transparency of most research institutions’ responses to allegations of research misconduct, and describes development of a proposed checklist to establish definitions and standards for complete research integrity investigations.
This randomized trial compares the effects of a periprocedural loading dose of atorvastatin vs placebo on major adverse cardiovascular events (MACE) at 30 days in patients with acute coronary syndrome (ACS) and planned percutaneous coronary intervention (PCI).
This JAMA Clinical Guidelines Synopsis summarizes the 2018 multisociety guideline on evaluation and treatment of hirsutism in premenopausal women.
This cohort study investigates the association between loss of hospital-based obstetric services between 2004 and 2014 and changes in location of childbirth and preterm births in rural counties in the United States.
This study uses NHANES data to estimate the mean population sodium intake and describe urinary potassium excretion among US adults aged 20 to 69 years.
This Medical News article examines why BMI-based definitions of overweight and obese might misclassify postmenopausal women as normal weight.
This Viewpoint argues that the therapeutic approach to bipolar disorder should mimic that for cancer, with immediate aggressive treatment and vigilant monitoring and follow-up to prevent long-term sequelae of disability, cognitive deficits, and suicide.