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Year

Day

January 17, 2020
Original Investigation

Caring for the Critically Ill Patient

Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial

Abstract Full Text
free access has multimedia
JAMA. Published online January 17, 2020. doi:10.1001/jama.2019.22190

This cluster randomized trial compares the effects of proton pump inhibitors (PPIs) vs histamine-2 receptor blockers (H2RBs) on 90-day mortality among patients requiring invasive mechanical ventilation within 24 hours of admission to the intensive care unit (ICU).

Preliminary Communication

Caring for the Critically Ill Patient

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial

Abstract Full Text
free access has multimedia
JAMA. Published online January 17, 2020. doi:10.1001/jama.2019.22176

This randomized clinical trial compares the effects of treatment with intravenous vitamin C, hydrocortisone, and thiamine compared with intravenous hydrocortisone alone on duration of time alive and free of vasopressor use over 7 days in patients with septic shock.

Editorial

Proton Pump Inhibitors vs Histamine-2 Receptor Blockers for Stress Ulcer Prophylaxis in Critically Ill Patients: Issues of Interpretability in Pragmatic Trials

Abstract Full Text
free access
JAMA. Published online January 17, 2020. doi:10.1001/jama.2019.22436

Lack of Benefit of High-Dose Vitamin C, Thiamine, and Hydrocortisone Combination for Patients With Sepsis

Abstract Full Text
free access
JAMA. Published online January 17, 2020. doi:10.1001/jama.2019.22438
January 16, 2020
Viewpoint

Sharing Health Care Data With Digital Giants: Overcoming Obstacles and Reaping Benefits While Protecting Patients

Abstract Full Text
free access
JAMA. Published online January 16, 2020. doi:10.1001/jama.2019.21215

This Viewpoint proposes principles of security, transparency, and privacy to guide data-sharing agreements between clinical organizations and digital technology companies as both seek electronic health record (EHR) data to grow their business and improve health care delivery and outcomes.

Sharing Patient Data Without Exploiting Patients

Abstract Full Text
free access
JAMA. Published online January 16, 2020. doi:10.1001/jama.2019.22354

This Viewpoint uses the framework of exploitation, an unequal sharing of benefits and harms between parties in an agreement, to highlight the ethical risks inherent in data-sharing partnerships between health systems and for-profit technology companies and to explore potential strategies for addressing those risks.

January 15, 2020
Medical News & Perspectives

Backlash Over Meat Dietary Recommendations Raises Questions About Corporate Ties to Nutrition Scientists

Abstract Full Text
free access
JAMA. Published online January 15, 2020. doi:10.1001/jama.2019.21441

This Medical News story examines the outcry over a recently published guideline that found insufficient evidence to recommend eating less red meat.

Correction

Missing Figure Legend

Abstract Full Text
free access
JAMA. Published online January 15, 2020. doi:10.1001/jama.2020.0138
January 13, 2020
Viewpoint

Incidental Imaging Findings in Clinical Trials

Abstract Full Text
free access
JAMA. Published online January 13, 2020. doi:10.1001/jama.2019.21813

This Viewpoint characterizes incidental radiographic findings from clinical trial–related imaging as an underrecognized potential harm of trial participation and proposes practices and standards to more systematically include them as a trial safety end point.

JAMA Clinical Guidelines Synopsis

Human Papillomavirus Vaccination for Adults: Updated Recommendations of the Advisory Committee on Immunization Practices (ACIP)

Abstract Full Text
JAMA. Published online January 13, 2020. doi:10.1001/jama.2019.18411

This JAMA Clinical Guidelines Synopsis summarizes the Advisory Committee on Immunization Practices’ 2019 updated recommendations for human papillomavirus vaccination for adults.

Correction

Incorrect Information

Abstract Full Text
free access
JAMA. Published online January 13, 2020. doi:10.1001/jama.2020.0097
January 10, 2020
Viewpoint

Evaluating the Potential Role of Social Media in Preventive Health Care

Abstract Full Text
free access
JAMA. Published online January 10, 2020. doi:10.1001/jama.2019.21084

In this Viewpoint, Raina Merchant uses the 2019 launch of Facebook’s Preventive Health tool, which makes preventive health recommendations based on user age and sex, to discuss the role of social media in influencing health behaviors, reaching vulnerable populations, and advancing public health.

JAMA Guide to Statistics and Methods

Using Propensity Score Methods to Create Target Populations in Observational Clinical Research

Abstract Full Text
JAMA. Published online January 10, 2020. doi:10.1001/jama.2019.21558

This JAMA Guide to Statistics and Methods reviews how propensity score methods can be used with observational data to mimic comparison populations in a randomized trial and account for differences that might lead to biased conclusions.

January 9, 2020
Viewpoint

A Prescription for Longevity in the 21st Century: Renewing Purpose, Building and Sustaining Social Engagement, and Embracing a Positive Lifestyle

Abstract Full Text
free access
JAMA. Published online January 9, 2020. doi:10.1001/jama.2019.21087

This Viewpoint considers how physicians can help patients align health span with life span given trends toward increased longevity and emphasizes the importance of a sense of purpose, social engagement, and lifestyle choices to improve outcomes of morbidity, mortality, and quality of life.

JAMA Insights

Women's Health

Osteoporosis Screening in Younger Postmenopausal Women

Abstract Full Text
JAMA. Published online January 9, 2020. doi:10.1001/jama.2019.18343

This JAMA Insights in the Women’s Health series summarizes USPSTF recommendations for screening postmenopausal women younger than 65 years for osteoporosis and advises use of the Osteoporosis Self-Assessment Tool (OST) for identifying younger women at risk of fracture who should undergo bone densitometry (DXA) testing.

January 8, 2020
Medical News & Perspectives

In Alzheimer Research, Glucose Metabolism Moves to Center Stage

Abstract Full Text
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JAMA. Published online January 8, 2020. doi:10.1001/jama.2019.20939

This Medical News article discusses the roles that glucose metabolism, diabetes medication, and lifestyle interventions may play in the development and progression of Alzheimer disease and other dementias.

January 6, 2020
Viewpoint

Challenges to the Reproducibility of Machine Learning Models in Health Care

Abstract Full Text
free access
JAMA. Published online January 6, 2020. doi:10.1001/jama.2019.20866

This Viewpoint reviews how machine learning models are developed and trained, discusses the challenges of reproducing medical machine learning model accuracy, and proposes practices and standards to improve the models’ reproducibility and replicability.

JAMA Clinical Challenge

Fever, Diarrhea, and Weight Loss in a Man With Inflammatory Polyarthritis

Abstract Full Text
has active quiz
JAMA. Published online January 6, 2020. doi:10.1001/jama.2019.18724

A 61-year-old man with seronegative rheumatoid arthritis had persistent polyarthralgias, fever, and unintentional weight loss with an elevated CRP level despite treatment; he also had intermittent abdominal pain, protein-losing enteropathy, and steatorrhea, and esophagogastroduodenoscopy findings of white duodenal plaques with biopsy showing macrophages in the duodenal mucosa. What is the diagnosis and what would you do next?

January 3, 2020
Medical News & Perspectives

The American Heart Association Takes on Vaping

Abstract Full Text
free access has audio
JAMA. Published online January 3, 2020. doi:10.1001/jama.2019.20781

This Medical News article is an interview with the American Heart Association’s Rose Marie Robertson, MD, about the explosion of electronic cigarette use among young people.

January 2, 2020
Viewpoint

Evolving Issues in Oncology

Adding Patient-Reported Outcomes to Medicare’s Oncology Value-Based Payment Model

Abstract Full Text
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JAMA. Published online January 2, 2020. doi:10.1001/jama.2019.19970

This Viewpoint discusses the Centers for Medicare & Medicaid Services proposed alternative payment model for medical oncology care, called Oncology Care First, that would replace the current expiring Oncology Care Model that was initiated in 2016, and adds the required collection of patient-reported outcomes.

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