This cluster randomized trial compares the effects of proton pump inhibitors (PPIs) vs histamine-2 receptor blockers (H2RBs) on 90-day mortality among patients requiring invasive mechanical ventilation within 24 hours of admission to the intensive care unit (ICU).
This randomized clinical trial compares the effects of treatment with intravenous vitamin C, hydrocortisone, and thiamine compared with intravenous hydrocortisone alone on duration of time alive and free of vasopressor use over 7 days in patients with septic shock.
This Viewpoint proposes principles of security, transparency, and privacy to guide data-sharing agreements between clinical organizations and digital technology companies as both seek electronic health record (EHR) data to grow their business and improve health care delivery and outcomes.
This Viewpoint uses the framework of exploitation, an unequal sharing of benefits and harms between parties in an agreement, to highlight the ethical risks inherent in data-sharing partnerships between health systems and for-profit technology companies and to explore potential strategies for addressing those risks.
This Medical News story examines the outcry over a recently published guideline that found insufficient evidence to recommend eating less red meat.
This Viewpoint characterizes incidental radiographic findings from clinical trial–related imaging as an underrecognized potential harm of trial participation and proposes practices and standards to more systematically include them as a trial safety end point.
This JAMA Clinical Guidelines Synopsis summarizes the Advisory Committee on Immunization Practices’ 2019 updated recommendations for human papillomavirus vaccination for adults.
In this Viewpoint, Raina Merchant uses the 2019 launch of Facebook’s Preventive Health tool, which makes preventive health recommendations based on user age and sex, to discuss the role of social media in influencing health behaviors, reaching vulnerable populations, and advancing public health.
This JAMA Guide to Statistics and Methods reviews how propensity score methods can be used with observational data to mimic comparison populations in a randomized trial and account for differences that might lead to biased conclusions.
This Viewpoint considers how physicians can help patients align health span with life span given trends toward increased longevity and emphasizes the importance of a sense of purpose, social engagement, and lifestyle choices to improve outcomes of morbidity, mortality, and quality of life.
This JAMA Insights in the Women’s Health series summarizes USPSTF recommendations for screening postmenopausal women younger than 65 years for osteoporosis and advises use of the Osteoporosis Self-Assessment Tool (OST) for identifying younger women at risk of fracture who should undergo bone densitometry (DXA) testing.
This Medical News article discusses the roles that glucose metabolism, diabetes medication, and lifestyle interventions may play in the development and progression of Alzheimer disease and other dementias.
This Viewpoint reviews how machine learning models are developed and trained, discusses the challenges of reproducing medical machine learning model accuracy, and proposes practices and standards to improve the models’ reproducibility and replicability.
A 61-year-old man with seronegative rheumatoid arthritis had persistent polyarthralgias, fever, and unintentional weight loss with an elevated CRP level despite treatment; he also had intermittent abdominal pain, protein-losing enteropathy, and steatorrhea, and esophagogastroduodenoscopy findings of white duodenal plaques with biopsy showing macrophages in the duodenal mucosa. What is the diagnosis and what would you do next?
This Medical News article is an interview with the American Heart Association’s Rose Marie Robertson, MD, about the explosion of electronic cigarette use among young people.
This Viewpoint discusses the Centers for Medicare & Medicaid Services proposed alternative payment model for medical oncology care, called Oncology Care First, that would replace the current expiring Oncology Care Model that was initiated in 2016, and adds the required collection of patient-reported outcomes.
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