This Viewpoint discusses the role of observational study designs and data in the rapid stand-up of an evidence base for managing the COVID-19 pandemic, proposing ways to position observational research as a foundation for rapid follow-on randomized evaluation without premature overinterpretation of its findings.
This Viewpoint describes indications and proper clinical use and interpretation of exome sequencing, explaining that the testing is not diagnostic in itself but requires correlation with patients’ history and presentation in the context of a comprehensive clinical evaluation.
This Viewpoint describes how the COVID-19 pandemic has made more obvious the work-life imbalance inherent in the practice of medicine and how the moment offers the profession the chance to recalibrate gender role stereotypes that have traditionally disadvantaged the careers of women physicians and researchers.
Anticipating widespread global use of dexamethasone for COVID-19 in the wake of RECOVERY trial findings, this Viewpoint summarizes the theoretical risk of triggering Strongyloides hyperinfection/dissemination syndrome in people with asymptomatic strongyloidiasis, and proposes an algorithm to for assessing and managing the risk in outpatient and hospital settings.
This Viewpoint discusses genome-wide sequencing (GWS) as a potential pathway not only to personalized medicine but also to population health, and proposes 5 dimensions health care organizations might consider when deciding on markers to screen for as they move toward genomic approaches to caring for their patient populations.
In this narrative medicine essay a father recalls the traumatic death of his healthy young son and the steps he and his family took to overcome their guilt, repair their relationships, and honor the boy’s life.
This population epidemiology study estimates associations of school closures in the US and the timing of those closures in March 2020 with change in daily coronavirus disease 2019 (COVID-19) incidence and mortality through the first week of May, accounting for other contemporaneous public health interventions.
This Viewpoint discusses the practice of using patient race as a variable in algorithms to determine kidney function and suggests that estimating tools be developed that are equally precise but exclude race as a factor.
This Viewpoint summarizes recommendations made in a National Academies of Sciences, Engineering, and Medicine report about how to safely reopen and operate elementary and secondary schools for the 2020-2021 school year, which emphasizes the need for partnerships with public health officials and community leaders, and for transparent communication of risks and rewards that will result from every policy decision.
This cross-sectional study compares the accuracy of plasma tau phosphorylated at threonine 217 (P-tau217) levels vs other plasma-, MRI-, CSF-, and PET-based markers for distinguishing Alzheimer from other neurodegenerative diseases in 3 cohorts in Arizona, Sweden, and Columbia with or at risk for dementia.
This nonrandomized controlled trial allowed children with appendicitis and their families to choose antibiotic therapy vs laparoscopic appendectomy as initial management, and compares 1-year disability days and treatment success—no need for later surgery—between the groups.
This Viewpoint uses US News & World Report’s annual hospital rankings to discuss how such efforts typically disadvantage hospitals caring for patients of lower socioeconomic status (SES) in regions with poorer population health, and argues for transparent and accurate ratings methods that use patient-centric quality measures and account for population SES.
This case series describes rare putative X-chromosomal loss-of-function variants associated with impaired peripheral mononuclear blood cell interferon signaling in 4 young male patients hospitalized with severe coronavirus disease 2019 (COVID-19) in the Netherlands.
This Viewpoint discusses evidence supporting use of conversational agents in health care—artificial intelligence (AI) programs that interpret users’ questions or concerns and respond with answers—and proposes 12 domains (eg, safety, transparency, security) that clinicians and health care organizations should evaluate before using them for patient care.
This Viewpoint describes the unique challenges faced by Lebanon, a small densely populated country with a fragmented health care system, in its response to the emerging COVID-19 pandemic, and it summarizes organizational, testing, and communications policies the nation has implemented that might be useful to other resource-limited countries and settings.
In this Viewpoint the president of the Ford Foundation calls on philanthropic and other wealthy organizations to make creative and generous grants to less well-endowed counterpart institutions and communities to redress the racial and socioeconomic disparities exposed by the COVID-19 pandemic and continued killings of Black Americans.
This Viewpoint discusses the success of US legislation to help prevent medication overdoses in children and suggests strategies to continue to reduce these overdoses, including changes to child-resistant packaging.
This Viewpoint proposes principles and processes to allow pooling of individual patient data from clinical trials given decelerating participant recruitment at sites where the COVID-19 surge has been controlled and new cases are diminishing.
This Viewpoint discusses the role of the Advisory Committee on Immunization Practices, a federal advisory committee that makes vaccine-related recommendations to the CDC and DHHS, in guiding the development and deployment of COVID-19 vaccines.
This JAMA Insights Clinical Update reviews the central role of apolipoprotein B100 molecule (apoB)–containing lipoproteins in the development of atherosclerotic cardiovascular disease (ASCVD), with implications for patient risk assessment and choice of lipid-lowering therapy.
This study examines the incidence of and risk factors for venous and arterial thrombosis in patients hospitalized with COVID-19 in 4 New York City hospitals.
This study uses diabetes registry data to compare the frequency of diabetic ketoacidosis (DKA) in children and adolescents at time of type 1 diabetes diagnosis in Germany during the first 2 months of the coronavirus disease 2019 (COVID-19) pandemic vs the same time period in 2018 and 2019.
A 68-year-old woman with history of uterine carcinoma (unknown histology) treated 30 years prior had 2 months of generalized abdominal pain and distention but no fever, nausea, vomiting, diarrhea, constipation, blood in the stool, or weight loss. CBC and serum chemistries were unremarkable; CT and MRI showed pelvic ascites and an enhancing lesion at the base of the cecum; CEA level was 18 ng/mL (normal <5 ng/mL). What is the diagnosis and what would you do next?
This Arts and Medicine feature discusses Amabié, a 19th-century Japanese yōkai character said to protect against spread of infection, who has become the symbol of public health hygiene in Japan during the COVID-19 pandemic.
In this narrative medicine essay, an emergency department physician faces her daily dread of donning PPE during the COVID-19 pandemic by recalling her grandfather’s gear when diving into Idaho mine shafts and compares his heroism fighting for miners’ rights to safety and wonders what he would think of calling health care works on the frontlines heroes.
This Medical News article discusses the mental and physical effects of infection-control lockdowns on nursing home residents during the novel coronavirus pandemic.
This study describes SARS-CoV-2 PCR test positivity among health care workers before, during, and after implementation of a policy requiring universal masking of all health care workers and patients in a large health care system in Massachusetts.
This Viewpoint summarizes recommendations from a 2020 National Academies of Sciences, Engineering, and Medicine (NASEM) report on transforming the infrastructure, funding, and methods of public health emergency preparedness and response (PHEPR) research to ensure it is grounded in the best science about what works where, why, and for whom.
This study compares pregnancy outcomes, including rates of stillbirth (fetal death ≥24 weeks’ gestation), preterm and cesarean delivery, and neonatal unit admission in the months preceding vs during the 2020 COVID-19 pandemic at a London university hospital.
This narrative review discusses what is currently known about the pathophysiology, epidemiology, diagnosis, management, prognosis, and prevention of coronavirus disease 2019 (COVID-19).
This JAMA Patient Page provides an overview of COVID-19 transmission, symptoms, diagnosis, disease course, and treatment.
This case series describes COVID-19 symptoms persisting a mean of 60 days after onset among Italian patients previously discharged from COVID-19 hospitalization.
In this narrative medicine essay, a gastroenterologist recalls a microagression from a patient during fellowship training and realizes the fault lay with the medicine profession and calls for antiracist training as one measure in dismantling race-based health disparities.
This Medical News story discusses the challenge of minimizing the risk of COVID-19 in kindergarten through 12th grades while maintaining prepandemic educational standards.
This study describes coronavirus disease 2019 (COVID-19) case rates and deaths among federal and state prisoners and compares them with corresponding rates for the US population.
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