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Year

Day

September 25, 2020
Viewpoint

The 2020 Lasker Awards and the COVID-19 Pandemic

Abstract Full Text
free access
JAMA. Published online September 25, 2020. doi:10.1001/jama.2020.17056

In this Viewpoint, the chair of the 2020 Lasker Medical Research Awards reflects on the history of the award program and its recipients as a stand-in for the 2020 awards, which are not being given because of the coronavirus disease 2019 (COVID-19) pandemic, and anticipates the most important research leading to COVID-19 treatment and control will be candidates for future recognition.

JAMA Insights

Women's Health

Managing Minimally Abnormal Cervical Cancer Screening Test Results

Abstract Full Text
JAMA. Published online September 25, 2020. doi:10.1001/jama.2020.12488

This JAMA Insights review summarizes 2020 consensus guidelines on management of minimally abnormal cervical cancer screening results, including no abnormal pathology, atypical squamous cells of undetermined significance (ASCUS), and low-grade squamous intraepithelial lesion (LSIL) with and without positive high-risk HPV testing.

September 24, 2020
Research Letter

Gastrointestinal Complications in Critically Ill Patients With and Without COVID-19

Abstract Full Text
free access
JAMA. Published online September 24, 2020. doi:10.1001/jama.2020.19400

This study compares the incidence of gastrointestinal complications of critically ill patients with COVID-19–induced acute respiratory distress syndrome (ARDS) vs comparably ill patients with non–COVID-19 ARDS using propensity score analysis.

Viewpoint

Revisiting the Roles of Primary Care Clinicians in Genetic Medicine

Abstract Full Text
free access
JAMA. Published online September 24, 2020. doi:10.1001/jama.2020.18745

This Viewpoint describes 4 approaches for primary care clinicians to incorporate genetics care into their practices, and the systems-level interventions needed to operationalize them, including collecting a family history, initiating genomic testing and diagnostic workup, referral to genetics subspecialists, and monitoring disease surveillance.

September 23, 2020
Research Letter

Association of SARS-CoV-2 Test Status and Pregnancy Outcomes

Abstract Full Text
free access
JAMA. Published online September 23, 2020. doi:10.1001/jama.2020.19124

This study examines the pregnancy outcomes of individuals infected with SARS-CoV-2 and those uninfected at a hospital in Sweden.

JAMA Diagnostic Test Interpretation

Coronary Computed Tomography Angiography

Abstract Full Text
has active quiz
JAMA. Published online September 23, 2020. doi:10.1001/jama.2020.10831

A 56-year-old woman with a history of CAD, hypertension controlled with medication, and a recent negative stress ECG for atypical chest pain underwent coronary CTA for persistent symptoms, which showed no stenosis or plaque. How would you follow up on the negative imaging result?

Medical News & Perspectives

As Their Numbers Grow, COVID-19 “Long Haulers” Stump Experts

Abstract Full Text
free access has audio
JAMA. Published online September 23, 2020. doi:10.1001/jama.2020.17709

This Medical News article discusses the puzzling phenomenon of “long-haulers,” patients who haven’t returned to full health weeks or even months after what sometimes is a mild case of COVID-19.

September 22, 2020
Viewpoint

Protecting the Editorial Independence of the CDC From Politics

Abstract Full Text
free access
JAMA. Published online September 22, 2020. doi:10.1001/jama.2020.19646

In this Viewpoint, 3 former editors of CDC’s Morbidity and Mortality Weekly Report (MMWR) respond to reports that political appointees have altered the timing and/or language of the publication to influence perceptions of the COVID-19 pandemic and suggest measures to preserve MMWR’s editorial independence and prevent future political interference.

September 21, 2020
Viewpoint

Ensuring Adequate Palliative and Hospice Care During COVID-19 Surges

Abstract Full Text
free access
JAMA. Published online September 21, 2020. doi:10.1001/jama.2020.16843

This Viewpoint discusses barriers to quality end-of-life care during the COVID-19 pandemic, including limited staffing, inadequate access to palliative medications, and restrictive visitation policies, and calls for proactive surge planning through organizational and policy reforms to facilitate symptom relief and comfort for patients dying in the pandemic.

A Piece of My Mind

Camping Alone—Recovering From COVID-19

Abstract Full Text
free access
JAMA. Published online September 21, 2020. doi:10.1001/jama.2020.19304

In this narrative medicine essay a medical student describes similarities between a challenging high school wilderness isolation camping trip and her experience in isolation with and recovering from COVID-19 in the early months of the pandemic in New York.

JAMA Insights

Clinical Update

Hormonal Contraception in Women With Hypertension

Abstract Full Text
free access
JAMA. Published online September 21, 2020. doi:10.1001/jama.2020.11935

This JAMA Insights article proposes an algorithm to guide the choice of oral contraceptives (OCs) for individuals with hypertension given the risk of elevated blood pressure and attendant complications of hypertension with OCs.

September 18, 2020
Research Letter

Nonfatal Opioid Overdoses at an Urban Emergency Department During the COVID-19 Pandemic

Abstract Full Text
free access
JAMA. Published online September 18, 2020. doi:10.1001/jama.2020.17477

This study compares the numbers of nonfatal, unintentional opioid-related opioid overdoses presenting to a US urban emergency department during the early months of the coronavirus disease 2019 (COVID-19) pandemic (March-June 2020) vs 2019, overall and by age, race/ethnicity, and insurance status.

Analysis of Drug Test Results Before and After the US Declaration of a National Emergency Concerning the COVID-19 Outbreak

Abstract Full Text
free access
JAMA. Published online September 18, 2020. doi:10.1001/jama.2020.17694

This substance use epidemiology study uses a commercial urine drug testing (UDT) service’s data to compare UDT results for cocaine, fentanyl, heroin, and methamphetamine before vs after US declaration of coronavirus disease 2019 (COVID-19) as a national emergency among patients diagnosed with or at risk of substance use disorders.

Viewpoint

Extreme Wildfires—A Growing Population Health and Planetary Problem

Abstract Full Text
free access
JAMA. Published online September 18, 2020. doi:10.1001/jama.2020.19334

This Viewpoint uses findings from a June 2019 National Academies of Sciences, Engineering, and Medicine (NASEM) workshop report and subsequent data to summarize known environmental and health effects of extreme wildfires, emphasizing their differential adverse effects on low-income, non–English-speaking, and other vulnerable communities.

Editorial

The Opioid Epidemic During the COVID-19 Pandemic

Abstract Full Text
free access
JAMA. Published online September 18, 2020. doi:10.1001/jama.2020.18543
September 17, 2020
Research Letter

Change in Antibodies to SARS-CoV-2 Over 60 Days Among Health Care Personnel in Nashville, Tennessee

Abstract Full Text
free access
JAMA. Published online September 17, 2020. doi:10.1001/jama.2020.18796

This study examines the duration of antibody response to SARS-CoV-2 in health care personnel over a 60-day period in Nashville, Tennessee.

Viewpoint

Another Medical Malpractice Crisis?Try Something Different

Abstract Full Text
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JAMA. Published online September 17, 2020. doi:10.1001/jama.2020.16557

This Viewpoint discusses the prospect of escalating malpractice claims and coverage costs in the wake of the COVID-19 pandemic, and proposes communication and resolution strategies focusing on patient safety, transparency, and proactive acknowledgement of error as an alternative to a defensive approach to claims and lawsuits.

September 16, 2020
Viewpoint

Occupational Safety and Health Administration (OSHA) and Worker Safety During the COVID-19 Pandemic

Abstract Full Text
free access
JAMA. Published online September 16, 2020. doi:10.1001/jama.2020.16343

This Viewpoint discusses the importance of preventive measures and supplies to reduce workplace COVID-19 transmission and calls for the US Occupational Safety and Health Administration (OSHA) to issue an enforceable requirement that employers implement standards and plans to minimize COVID-19 incidence among essential workers and spread to their families and communities.

Suboptimal US Response to COVID-19 Despite Robust Capabilities and Resources

Abstract Full Text
free access
JAMA. Published online September 16, 2020. doi:10.1001/jama.2020.17395

This Viewpoint attempts to reconcile the US’s high 2019 preparedness ranking on the Global Health Security Index, an international framework for benchmarking health security, and its faltering coronavirus disease 2019 (COVID-19) pandemic response, and explores lessons learned from other countries whose higher rankings and efficient responses were more closely aligned.

Medical News & Perspectives

The Science of Persuasion Offers Lessons for COVID-19 Prevention

Abstract Full Text
free access has audio
JAMA. Published online September 16, 2020. doi:10.1001/jama.2020.15139

In this Medical News article, science communications expert Dominique Brossard, PhD, discusses research-based strategies to encourage COVID-19-mitigating behaviors.

Quick Uptakes

Investigating Whether Blood Type Is Linked to COVID-19 Risk

Abstract Full Text
free access
JAMA. Published online September 16, 2020. doi:10.1001/jama.2020.16516

This Medical News Quick Uptake discusses research into whether blood type is linked to COVID-19 risk.

September 14, 2020
Research Letter

Change in Donor Characteristics and Antibodies to SARS-CoV-2 in Donated Blood in the US, June-August 2020

Abstract Full Text
free access
JAMA. Published online September 14, 2020. doi:10.1001/jama.2020.18598

This study describes changes in blood donor demographics and seroreactivity after testing of blood donations for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies began and was publicized in the US in mid-June 2020.

Viewpoint

The Case for Algorithmic Stewardship for Artificial Intelligence and Machine Learning Technologies

Abstract Full Text
free access has audio
JAMA. Published online September 14, 2020. doi:10.1001/jama.2020.9371

This Viewpoint proposes creation of algorithmic stewardship programs at health systems, tasked similar to antibiotic stewardship committees with oversight of artificial intelligence and machine learning technologies to ensure they are used safely, effectively, fairly, and to the benefit of diverse patient populations.

JAMA Clinical Challenge

Pruritus and Tense Bullae After Discontinuation of Pembrolizumab in a Patient With Renal Cell Carcinoma

Abstract Full Text
has active quiz
JAMA. Published online September 14, 2020. doi:10.1001/jama.2020.10159

A 53-year-old woman developed widespread tense bullae with pruritus and oral mucosal lesions recalcitrant to corticosteroids during a treatment with pembrolizumab for stage IV renal cell carcinoma that persisted after discontinuation of the drug. ESR and CRP levels were elevated and biopsy suggested an autoimmune bullous process, but direct immunofluorescence results were negative. What is the diagnosis and what would you do next?

September 11, 2020
Viewpoint

COVID-19 and the Path to Immunity

Abstract Full Text
free access has active quiz
JAMA. Published online September 11, 2020. doi:10.1001/jama.2020.16656

This Viewpoint reviews what is known about acute and long-term B-cell, antibody, and T-cell responses to SARS-CoV-2 infection and explains how each are implicated in vaccine candidates likely to be effective and durably protective again COVID-19.

Radiology and Value-Based Health Care

Abstract Full Text
free access
JAMA. Published online September 11, 2020. doi:10.1001/jama.2020.14930

This Viewpoint discusses the importance of transitioning radiology from a volume-based to a value-based practice and specialty, starting from within with an effort by radiologists to help define and create that value for referring clinicians and the patients and health care systems they serve.

September 10, 2020
Research Letter

Racial/Ethnic Variation in Nasal Gene Expression of Transmembrane Serine Protease 2 (TMPRSS2)

Abstract Full Text
free access has active quiz
JAMA. Published online September 10, 2020. doi:10.1001/jama.2020.17386

This cross-sectional study used nasal epithelium collected in 2015-2018 to compare expression of TMPRSS2, a facilitator of SARS-CoV-2 viral entry and spread, among Asian, Black, Latino, and White patients as well as patients of mixed race/ethnicity within a New York City health system.

Viewpoint

Fairly Prioritizing Groups for Access to COVID-19 Vaccines

Abstract Full Text
free access has active quiz has audio
JAMA. Published online September 10, 2020. doi:10.1001/jama.2020.18513

This Viewpoint proposes that ethical principles of preventing harm, helping disadvantaged populations, and achieving equal treatment should guide COVID-19 vaccine distribution, supporting initial allocation to health care workers, people in high-risk occupations and housing, and those with high-risk medical conditions.

Oral Health in Medicare: Considerations for 21st-Century Coverage

Abstract Full Text
free access
JAMA. Published online September 10, 2020. doi:10.1001/jama.2020.3003

This Viewpoint discusses the need to expand Medicare benefits to include coverage for oral health services given the inextricable connection between diseases of the mouth, gums, and teeth and systemic disease, such as with stem cell transplants and immunosuppression, prosthetic heart valves, and bisphosphonate use.

Editorial

Reassuring the Public and Clinical Community About the Scientific Review and Approval of a COVID-19 Vaccine

Abstract Full Text
free access has active quiz has multimedia has audio
JAMA. Published online September 10, 2020. doi:10.1001/jama.2020.18860
September 8, 2020
Research Letter

Prevalence of Third-Party Tracking on COVID-19–Related Web Pages

Abstract Full Text
free access has active quiz
JAMA. Published online September 8, 2020. doi:10.1001/jama.2020.16178

This study uses webXray, an automated tool that detects tracking on websites, to describe the prevalence and characteristics of third-party data requests and cookies on the top 20 COVID-19–related websites, including academic and government sites, from US-based search results in May 2020.

Correction

Update to Conference Dates

Abstract Full Text
free access
JAMA. Published online September 8, 2020. doi:10.1001/jama.2020.18492
September 3, 2020
Research Letter

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

Abstract Full Text
has active quiz
JAMA. Published online September 3, 2020. doi:10.1001/jama.2020.17052

This study compares levels of tumor necrosis factor α, IL-6, and IL-8 in critically ill patients with coronavirus disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution of cytokine storm to COVID-19 pathophysiology.

September 2, 2020
Original Investigation

Caring for the Critically Ill Patient

Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial

Abstract Full Text
free access has active quiz has multimedia has audio
JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.16761

This randomized clinical trial compares the effect of low-dose hydrocortisone vs placebo on treatment failure (death or persistent respiratory support dependency) at 21 days in critically ill patients with COVID-19 and acute respiratory failure in France.

Caring for the Critically Ill Patient

Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial

Abstract Full Text
free access has active quiz has multimedia has audio
JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.17021

This open label clinical trial compares the effects of dexamethasone vs usual care on the number of days alive and free of mechanical ventilation at day 28 among COVID-19 patients in Brazil with moderate to severe acute respiratory distress syndrome (ARDS).

Caring for the Critically Ill Patient

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial

Abstract Full Text
free access has active quiz has multimedia has audio
JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.17022

This open-label randomized trial compares the effects of fixed-dose vs shock-dependent vs no intravenous hydrocortisone on organ support–free days among patients with coronavirus disease 2019 (COVID-19) admitted to critical care units (ICU/CCUs) for respiratory or cardiovascular organ support.

Caring for the Critically Ill Patient

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis

Abstract Full Text
free access has active quiz has multimedia has audio
JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.17023

This meta-analysis pools data from 7 randomized trials to estimate the association between administration of corticosteroids vs usual care or placebo and all-cause mortality at 28 days in patients with severe coronavirus disease 2019 (COVID-19).

Editorial

Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic

Abstract Full Text
free access has active quiz has multimedia has audio
JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.16747
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