In this Viewpoint, the chair of the 2020 Lasker Medical Research Awards reflects on the history of the award program and its recipients as a stand-in for the 2020 awards, which are not being given because of the coronavirus disease 2019 (COVID-19) pandemic, and anticipates the most important research leading to COVID-19 treatment and control will be candidates for future recognition.
This JAMA Insights review summarizes 2020 consensus guidelines on management of minimally abnormal cervical cancer screening results, including no abnormal pathology, atypical squamous cells of undetermined significance (ASCUS), and low-grade squamous intraepithelial lesion (LSIL) with and without positive high-risk HPV testing.
This study compares the incidence of gastrointestinal complications of critically ill patients with COVID-19–induced acute respiratory distress syndrome (ARDS) vs comparably ill patients with non–COVID-19 ARDS using propensity score analysis.
This Viewpoint describes 4 approaches for primary care clinicians to incorporate genetics care into their practices, and the systems-level interventions needed to operationalize them, including collecting a family history, initiating genomic testing and diagnostic workup, referral to genetics subspecialists, and monitoring disease surveillance.
This study examines the pregnancy outcomes of individuals infected with SARS-CoV-2 and those uninfected at a hospital in Sweden.
A 56-year-old woman with a history of CAD, hypertension controlled with medication, and a recent negative stress ECG for atypical chest pain underwent coronary CTA for persistent symptoms, which showed no stenosis or plaque. How would you follow up on the negative imaging result?
This Medical News article discusses the puzzling phenomenon of “long-haulers,” patients who haven’t returned to full health weeks or even months after what sometimes is a mild case of COVID-19.
In this Viewpoint, 3 former editors of CDC’s Morbidity and Mortality Weekly Report (MMWR) respond to reports that political appointees have altered the timing and/or language of the publication to influence perceptions of the COVID-19 pandemic and suggest measures to preserve MMWR’s editorial independence and prevent future political interference.
This Viewpoint discusses barriers to quality end-of-life care during the COVID-19 pandemic, including limited staffing, inadequate access to palliative medications, and restrictive visitation policies, and calls for proactive surge planning through organizational and policy reforms to facilitate symptom relief and comfort for patients dying in the pandemic.
In this narrative medicine essay a medical student describes similarities between a challenging high school wilderness isolation camping trip and her experience in isolation with and recovering from COVID-19 in the early months of the pandemic in New York.
This JAMA Insights article proposes an algorithm to guide the choice of oral contraceptives (OCs) for individuals with hypertension given the risk of elevated blood pressure and attendant complications of hypertension with OCs.
This study compares the numbers of nonfatal, unintentional opioid-related opioid overdoses presenting to a US urban emergency department during the early months of the coronavirus disease 2019 (COVID-19) pandemic (March-June 2020) vs 2019, overall and by age, race/ethnicity, and insurance status.
This substance use epidemiology study uses a commercial urine drug testing (UDT) service’s data to compare UDT results for cocaine, fentanyl, heroin, and methamphetamine before vs after US declaration of coronavirus disease 2019 (COVID-19) as a national emergency among patients diagnosed with or at risk of substance use disorders.
This Viewpoint uses findings from a June 2019 National Academies of Sciences, Engineering, and Medicine (NASEM) workshop report and subsequent data to summarize known environmental and health effects of extreme wildfires, emphasizing their differential adverse effects on low-income, non–English-speaking, and other vulnerable communities.
This study examines the duration of antibody response to SARS-CoV-2 in health care personnel over a 60-day period in Nashville, Tennessee.
This Viewpoint discusses the prospect of escalating malpractice claims and coverage costs in the wake of the COVID-19 pandemic, and proposes communication and resolution strategies focusing on patient safety, transparency, and proactive acknowledgement of error as an alternative to a defensive approach to claims and lawsuits.
This Viewpoint discusses the importance of preventive measures and supplies to reduce workplace COVID-19 transmission and calls for the US Occupational Safety and Health Administration (OSHA) to issue an enforceable requirement that employers implement standards and plans to minimize COVID-19 incidence among essential workers and spread to their families and communities.
This Viewpoint attempts to reconcile the US’s high 2019 preparedness ranking on the Global Health Security Index, an international framework for benchmarking health security, and its faltering coronavirus disease 2019 (COVID-19) pandemic response, and explores lessons learned from other countries whose higher rankings and efficient responses were more closely aligned.
In this Medical News article, science communications expert Dominique Brossard, PhD, discusses research-based strategies to encourage COVID-19-mitigating behaviors.
This Medical News Quick Uptake discusses research into whether blood type is linked to COVID-19 risk.
This study describes changes in blood donor demographics and seroreactivity after testing of blood donations for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies began and was publicized in the US in mid-June 2020.
This Viewpoint proposes creation of algorithmic stewardship programs at health systems, tasked similar to antibiotic stewardship committees with oversight of artificial intelligence and machine learning technologies to ensure they are used safely, effectively, fairly, and to the benefit of diverse patient populations.
A 53-year-old woman developed widespread tense bullae with pruritus and oral mucosal lesions recalcitrant to corticosteroids during a treatment with pembrolizumab for stage IV renal cell carcinoma that persisted after discontinuation of the drug. ESR and CRP levels were elevated and biopsy suggested an autoimmune bullous process, but direct immunofluorescence results were negative. What is the diagnosis and what would you do next?
This Viewpoint reviews what is known about acute and long-term B-cell, antibody, and T-cell responses to SARS-CoV-2 infection and explains how each are implicated in vaccine candidates likely to be effective and durably protective again COVID-19.
This Viewpoint discusses the importance of transitioning radiology from a volume-based to a value-based practice and specialty, starting from within with an effort by radiologists to help define and create that value for referring clinicians and the patients and health care systems they serve.
This cross-sectional study used nasal epithelium collected in 2015-2018 to compare expression of TMPRSS2, a facilitator of SARS-CoV-2 viral entry and spread, among Asian, Black, Latino, and White patients as well as patients of mixed race/ethnicity within a New York City health system.
This Viewpoint proposes that ethical principles of preventing harm, helping disadvantaged populations, and achieving equal treatment should guide COVID-19 vaccine distribution, supporting initial allocation to health care workers, people in high-risk occupations and housing, and those with high-risk medical conditions.
This Viewpoint discusses the need to expand Medicare benefits to include coverage for oral health services given the inextricable connection between diseases of the mouth, gums, and teeth and systemic disease, such as with stem cell transplants and immunosuppression, prosthetic heart valves, and bisphosphonate use.
This study uses webXray, an automated tool that detects tracking on websites, to describe the prevalence and characteristics of third-party data requests and cookies on the top 20 COVID-19–related websites, including academic and government sites, from US-based search results in May 2020.
This study compares levels of tumor necrosis factor α, IL-6, and IL-8 in critically ill patients with coronavirus disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution of cytokine storm to COVID-19 pathophysiology.
This randomized clinical trial compares the effect of low-dose hydrocortisone vs placebo on treatment failure (death or persistent respiratory support dependency) at 21 days in critically ill patients with COVID-19 and acute respiratory failure in France.
This open label clinical trial compares the effects of dexamethasone vs usual care on the number of days alive and free of mechanical ventilation at day 28 among COVID-19 patients in Brazil with moderate to severe acute respiratory distress syndrome (ARDS).
This open-label randomized trial compares the effects of fixed-dose vs shock-dependent vs no intravenous hydrocortisone on organ support–free days among patients with coronavirus disease 2019 (COVID-19) admitted to critical care units (ICU/CCUs) for respiratory or cardiovascular organ support.
This meta-analysis pools data from 7 randomized trials to estimate the association between administration of corticosteroids vs usual care or placebo and all-cause mortality at 28 days in patients with severe coronavirus disease 2019 (COVID-19).
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