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January 21, 2022
Original Investigation

Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants

Abstract Full Text
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JAMA. Published online January 21, 2022. doi:10.1001/jama.2022.0470

This case-control study uses data from the Centers for Disease Control and Prevention Increasing Community Access to Testing platform to estimate the association between receipt of 3 doses of Pfizer-BioNTech BNT162b2 or Moderna mRNA-1273 vaccine, compared with 2 doses or unvaccinated, and symptomatic SARS-CoV-2 infection, stratified by Omicron and Delta variant.

Viewpoint

Preventing Digital Overdiagnosis

Abstract Full Text
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JAMA. Published online January 21, 2022. doi:10.1001/jama.2021.22969

This Viewpoint proposes using large longitudinal databases of patient information that describe clinical trajectories and outcomes to preemptively quantify the risk of overdiagnosis posed by new digital screening technologies.

The Quintuple Aim for Health Care Improvement: A New Imperative to Advance Health Equity

Abstract Full Text
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JAMA. Published online January 21, 2022. doi:10.1001/jama.2021.25181

This Viewpoint proposes expanding the quadruple aim (improving population health, enhancing the care experience, reducing costs, and addressing clinician burnout) to the quintuple aim, adding a fifth aim of advancing health equity.

Equity and Quality—Improving Health Care Delivery Requires Both

Abstract Full Text
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JAMA. Published online January 21, 2022. doi:10.1001/jama.2022.0283

This Viewpoint argues that equitable health care is not possible without the delivery of high-quality care and vice versa.

The US Supreme Court’s Rulings on Large Business and Health Care Worker Vaccine Mandates: Ramifications for the COVID-19 Response and the Future of Federal Public Health Protection

Abstract Full Text
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JAMA. Published online January 21, 2022. doi:10.1001/jama.2022.0852

This Viewpoint examines the recent US Supreme Court rulings on government mandates for COVID-19 vaccination and how these decisions might affect the ongoing pandemic response as well as the future of public health.

Editorial

Booster Vaccination to Prevent COVID-19 in the Era of Omicron: An Effective Part of a Layered Public Health Approach

Abstract Full Text
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JAMA. Published online January 21, 2022. doi:10.1001/jama.2022.0892
Medical News & Perspectives

How the Supreme Court’s COVID-19 Vaccine Mandate Rulings Could Shape the Pandemic’s Next Phase

Abstract Full Text
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JAMA. Published online January 21, 2022. doi:10.1001/jama.2022.0791

This Medical News article discusses the Supreme Court’s recent decision to allow federally mandated COVID-19 vaccinations for health care workers but not the broader US workforce.

January 20, 2022
Research Letter

Comparison of mRNA-1273 and BNT162b2 Vaccines on Breakthrough SARS-CoV-2 Infections, Hospitalizations, and Death During the Delta-Predominant Period

Abstract Full Text
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JAMA. Published online January 20, 2022. doi:10.1001/jama.2022.0210

This study examines breakthrough SARS-CoV-2 infections, hospitalizations, and mortality in March-August 2021, when the Delta variant predominated, among a general US cohort vaccinated with mRNA-1273 or BNT162b2.

Viewpoint

Diagnostic Excellence

At-home Diagnostics and Diagnostic Excellence: Devices vs General Wellness Products

Abstract Full Text
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JAMA. Published online January 20, 2022. doi:10.1001/jama.2022.0047

This Viewpoint discusses the definitions of medical devices and low-risk general wellness products and examines the difficulties the difference between these types of products pose for regulation, consumer understanding, physician use and interpretation, privacy, reimbursement, and equity.

January 19, 2022
Medical News & Perspectives

Vaccine Development Is Charting a New Path in Malaria Control

Abstract Full Text
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JAMA. Published online January 19, 2022. doi:10.1001/jama.2021.20627

This Medical News article discusses the first ever malaria vaccine, which begins rolling out this year in sub-Saharan Africa.

January 18, 2022
Medical News & Perspectives

Former Biden-Harris Transition Advisors Propose a New National Strategy for COVID-19

Abstract Full Text
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JAMA. Published online January 18, 2022. doi:10.1001/jama.2022.0216

This Medical News article is based on an interview with 3 members of the former Biden-Harris Transition COVID-19 Advisory Board.

January 14, 2022
Original Investigation

Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial

Abstract Full Text
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JAMA. Published online January 14, 2022. doi:10.1001/jama.2021.24939

This randomized trial assesses the effect of a single dose of subcutaneous casirivimab and imdevimab antibody combination vs placebo on 28-day progression to symptomatic COVID-19 among asymptomatic SARS-CoV-2 reverse transcriptase–quantitative polymerase chain reaction–positive individuals living with an infected household contact.

Viewpoint

Hierarchical Payment Models—A Path for Coordinating Population- and Episode-Based Payment Models

Abstract Full Text
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JAMA. Published online January 14, 2022. doi:10.1001/jama.2021.23786

This Viewpoint discusses the implications from data on value-based payments, policy design regarding population- and episode-based payments, and the benefits of coordinated payment models that may contribute toward reaching the Centers for Medicare & Medicaid Services’ strategy, announced in November 2021, for achieving near-universal participation in value-based payment models by 2030.

COVID-19 Therapeutics for Nonhospitalized Patients

Abstract Full Text
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JAMA. Published online January 14, 2022. doi:10.1001/jama.2022.0335

This Viewpoint provides a summary of currently available therapeutics for nonhospitalized patients with COVID-19 in the setting of the Omicron variant including principles for equitable allocation.

Editorial

Realizing the Potential of Anti–SARS-CoV-2 Monoclonal Antibodies for COVID-19 Management

Abstract Full Text
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JAMA. Published online January 14, 2022. doi:10.1001/jama.2021.19994
January 13, 2022
Research Letter

US Insurer Spending on Ivermectin Prescriptions for COVID-19

Abstract Full Text
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JAMA. Published online January 13, 2022. doi:10.1001/jama.2021.24352

This study examines insurer coverage of ivermectin prescriptions for COVID-19 in the US.

Viewpoint

Mitigating the Long-term Health Risks of Adverse Pregnancy Outcomes

Abstract Full Text
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JAMA. Published online January 13, 2022. doi:10.1001/jama.2021.23870

This Viewpoint discusses the increased long-term risks for cardiovascular disease among individuals who have had adverse pregnancy outcomes and describes mitigation strategies for physicians to use over the life span of these patients.

January 12, 2022
Medical News & Perspectives

Preparing Hospitals’ Medical Oxygen Delivery Systems for a Respiratory “Twindemic”

Abstract Full Text
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JAMA. Published online January 12, 2022. doi:10.1001/jama.2021.23392

This Medical News feature examines the challenges that hospitals face as they prepare for a spike in severe cases of COVID-19 and other respiratory illnesses that require supplemental oxygen.

Quick Uptakes

Study: Business Booms for Unlicensed and Unproven Stem Cell Treatments

Abstract Full Text
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JAMA. Published online January 12, 2022. doi:10.1001/jama.2021.22793

This Medical News article examines the growing business of unlicensed and unproven stem cell treatments.

January 11, 2022
Medical News & Perspectives

COVID-19 Vaccines Have Been Available in the US for More Than a Year—What’s Been Learned and What’s Next?

Abstract Full Text
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JAMA. Published online January 11, 2022. doi:10.1001/jama.2022.0106

This Medical News article on COVID-19 vaccines is adapted from a JAMA interview with the CDC’s Amanda Cohn, MD.

January 10, 2022
Original Investigation

Association of a Third Dose of BNT162b2 Vaccine With Incidence of SARS-CoV-2 Infection Among Health Care Workers in Israel

Abstract Full Text
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JAMA. Published online January 10, 2022. doi:10.1001/jama.2021.23641

This cohort study estimates the association of a BNT162b2 (Pfizer-BioNTech) vaccine booster dose with SARS-CoV-2 infections among health care workers in Israel previously vaccinated with a 2-dose series of BNT162b2.

Editorial

Booster Vaccination to Reduce SARS-CoV-2 Transmission and Infection

Abstract Full Text
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JAMA. Published online January 10, 2022. doi:10.1001/jama.2021.23726
January 7, 2022
Research Letter

False-Positive Results in Rapid Antigen Tests for SARS-CoV-2

Abstract Full Text
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JAMA. Published online January 7, 2022. doi:10.1001/jama.2021.24355

This study examines the incidence of false-positive results in a sample of rapid antigen tests used to serially screen asymptomatic workers throughout Canada.

Viewpoint

Shifting to Serious Illness Communication

Abstract Full Text
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JAMA. Published online January 7, 2022. doi:10.1001/jama.2021.23695

This Viewpoint focuses on an emerging intervention, serious illness communication, and describes its components, presents evidence supporting the approach, and discusses areas for further research.

The Dysfunctional Health Benefits Market and Implications for US Employers and Employees

Abstract Full Text
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JAMA. Published online January 7, 2022. doi:10.1001/jama.2021.23258

This Viewpoint discusses addressing the problems in the health benefits market, which contribute to wage stagnation and rising economic inequality.

Diagnostic Excellence

The Rational Diagnostician and Achieving Diagnostic Excellence

Abstract Full Text
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JAMA. Published online January 7, 2022. doi:10.1001/jama.2021.24988

This Viewpoint outlines approaches to successfully make clinical diagnoses, including coaching medical students in critical thinking and decision-making, promoting interdisciplinary teamwork, and mitigating judgment and decision-making biases.

January 5, 2022
Medical News & Perspectives

Highlights From the American Heart Association’s Scientific Sessions—ApoB as a Risk Marker, an Oral PCSK9 Inhibitor, and Aspirin and Dementia

Abstract Full Text
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JAMA. Published online January 5, 2022. doi:10.1001/jama.2021.21397

Timely topics discussed at the American Heart Association’s Scientific Sessions in November 2021 included using apolipoprotein B to predict the risk of future myocardial infarction.

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