Updated March 2023 - Coronavirus (COVID-19) Resource Center | JAMA

With the global coronavirus pandemic in its fourth year, a majority of the US population is now estimated to have some immunity to SARS-CoV-2 through vaccination or natural infection, but its effects are still being felt in the form of COVID-19 outbreaks from emerging subvariants, lasting symptoms (PASC or Long Covid), excess population mortality, and more.

Browse JAMA Network’s COVID-19 featured content below to learn more, including ivermectin trials, historic Q&A's with former NIAID Director Anthony Fauci, and Patient Information pages.

This page is updated every Friday.

Featured
Levels of Complement Components in Children With Acute COVID-19 or Multisystem Inflammatory Syndrome Rajamanickam A, Nathella PK, Venkataraman A, et al. JAMA Network Open March 24, 2023
While Waiting for a Randomized Clinical Trial of Nirmatrelvir for Prevention of Post–COVID-19 Condition Katz MH JAMA Internal Medicine March 23, 2023
Association of Treatment With Nirmatrelvir and the Risk of Post–COVID-19 Condition Xie Y, Choi T, Al-Aly Z JAMA Internal Medicine March 23, 2023
Risk Factors Associated With Post−COVID-19 Condition: A Systematic Review and Meta-analysis Tsampasian V, Elghazaly H, Chattopadhyay R, et al. JAMA Internal Medicine March 23, 2023
Sex-Specific Neurodevelopmental Outcomes Among Offspring of Mothers With SARS-CoV-2 Infection During Pregnancy Edlow AG, Castro VM, Shook LL, Haneuse S, Kaimal AJ, Perlis RH JAMA Network Open March 23, 2023
Nasally Administered Monoclonal Antibody for COVID-19 Harris E JAMA March 22, 2023
Anticoagulation in Patients With COVID-19 Pneumonia—What Is the Optimal Intensity? Becker RC, Ortel TL JAMA Internal Medicine March 22, 2023
Effects of Standard-Dose Prophylactic, High-Dose Prophylactic, and Therapeutic Anticoagulation in Patients With Hypoxemic COVID-19 Pneumonia: The ANTICOVID Randomized Clinical Trial Labbé V, Contou D, Heming N, et al. JAMA Internal Medicine March 22, 2023
Prevalence of Myopia in Children Before, During, and After COVID-19 Restrictions in Hong Kong Zhang XJ, Zhang Y, Kam KW, et al. JAMA Network Open March 22, 2023
Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19 Goligher EC, Lawler PR, Jensen TP, et al. JAMA March 21, 2023

Coronavirus (COVID-19) Q&A

Conversations with Frontline Clinicians and Experts about the COVID-19 pandemic.

Coronavirus Video Q&A JAMA Network editors interview guests about the latest developments in the global coronavirus outbreak. Watch for updates on COVID-19 diagnosis and treatment.
Coronavirus Audio Q&A Conversations with frontline clinicians and experts on the frontiers of the global COVID-19 pandemic, hosted by JAMA Network editors.

Editors' Choice
Effects of Standard-Dose Prophylactic, High-Dose Prophylactic, and Therapeutic Anticoagulation in Patients With Hypoxemic COVID-19 Pneumonia: The ANTICOVID Randomized Clinical Trial Labbé V, Contou D, Heming N, et al. JAMA Internal Medicine March 22, 2023
Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial Naggie S, Boulware DR, Lindsell CJ, et al. JAMA February 20, 2023
Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial McCarthy MW, Naggie S, Boulware DR, et al. JAMA January 12, 2023
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Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial Naggie S, Boulware DR, Lindsell CJ, et al. JAMA October 21, 2022
Dr Fauci and the Art of Science Communication Suran M JAMA September 9, 2022
Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-analysis Lee TC, Vigod S, Bortolussi-Courval É, et al. JAMA Network Open April 6, 2022
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Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial REMAP-CAP Writing Committee for the REMAP-CAP Investigators JAMA March 22, 2022
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Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial Lim SCL, Hor CP, Tay KH, et al. JAMA Internal Medicine February 18, 2022
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Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial Perkins GD, Ji C, Connolly BA, et al. JAMA January 24, 2022
A National Strategy for the “New Normal” of Life With COVID Emanuel EJ, Osterholm M, Gounder CR JAMA January 6, 2022
Winter of Omicron—The Evolving COVID-19 Pandemic del Rio C, Omer SB, Malani PN JAMA December 22, 2021
One Year of COVID-19 Vaccines: A Shot of Hope, a Dose of Reality Cohn AC, Mahon BE, Walensky RP JAMA December 21, 2021
Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barré Syndrome, February-July 2021 Woo EJ, Mba-Jonas A, Dimova RB, Alimchandani M, Zinderman CE, Nair N JAMA October 7, 2021
Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial Spyropoulos AC, Goldin M, Giannis D, et al. JAMA Internal Medicine October 7, 2021
Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial Writing Committee for the REMAP-CAP Investigators JAMA October 4, 2021
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group JAMA July 6, 2021
Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military Montgomery J, Ryan M, Engler R, et al. JAMA Cardiology June 29, 2021
US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021 See I, Su JR, Lale A, et al. JAMA April 30, 2021
SARS-CoV-2–Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women Perl SH, Uzan-Yulzari A, Klainer H, et al. JAMA April 12, 2021
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Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial INSPIRATION Investigators JAMA March 18, 2021
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Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial López-Medina E, López P, Hurtado IC, et al. JAMA March 4, 2021
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SARS-CoV-2 Vaccines Creech CB, Walker SC, Samuels RJ JAMA February 26, 2021
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Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19 Feldstein LR, Tenforde MW, Friedman KG, et al. JAMA February 24, 2021
Effectiveness of Mask Wearing to Control Community Spread of SARS-CoV-2 Brooks JT, Butler JC JAMA February 10, 2021
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Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children Ouldali N, Toubiana J, Antona D, et al. JAMA February 1, 2021
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SARS-CoV-2 Transmission From People Without COVID-19 Symptoms Johansson MA, Quandelacy TM, Kada S, et al. JAMA Network Open January 7, 2021
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Genetic Variants of SARS-CoV-2—What Do They Mean? Lauring AS, Hodcroft EB JAMA January 6, 2021
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Therapy for Early COVID-19: A Critical Need Kim PS, Read SW, Fauci AS JAMA November 11, 2020
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COVID-19 and the Path to Immunity Stephens DS, McElrath MJ JAMA September 11, 2020
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Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group JAMA September 2, 2020
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Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) Wiersinga WJ, Rhodes A, Cheng AC, et al. JAMA July 10, 2020
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Is the Prone Position Helpful During Spontaneous Breathing in Patients With COVID-19? Telias I, Katira BH, Brochard L JAMA May 15, 2020
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Public Health Measures and the Reproduction Number of SARS-CoV-2 Inglesby TV JAMA May 1, 2020
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China 中文 (chinese) Wu Z, McGoogan JM JAMA February 24, 2020
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Characteristics of Hospitalized Patients With 2019-nCoV Pneumonia in Wuhan, China 中文 (chinese) Wang D, Hu B, Hu C, et al. JAMA February 7, 2020
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Coronavirus Infections—More Than Just the Common Cold Paules CI, Marston HD, Fauci AS JAMA January 23, 2020

Patient Information

Easy-to-understand information on COVID-19 to share with patients and their families.

Preventive Medication for COVID-19 Infection Malani AG, Malani AN JAMA July 25, 2022
Oral Antiviral Medications for COVID-19 Petty LA, Malani PN JAMA April 25, 2022
COVID-19 and Pregnancy Walter K JAMA December 10, 2021
Variants of SARS-CoV-2 Lauring AS, Malani PN JAMA August 13, 2021
Olfactory Loss and Olfactory Training Patel ZM JAMA Otolaryngology July 15, 2021
Return to Play After COVID-19 Infection in Children Thompson LA, Kelly MN JAMA Pediatrics June 28, 2021
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Children and COVID-19 Vaccines Thompson LA, Rasmussen SA JAMA Pediatrics June 4, 2021
Monoclonal Antibodies for COVID-19 Lloyd EC, Gandhi TN, Petty LA JAMA February 5, 2021
Necessity of 2 Doses of the Pfizer and Moderna COVID-19 Vaccines Livingston EH JAMA February 3, 2021
One Year Later, How Does COVID-19 Affect Children? Thompson LA, Rasmussen SA JAMA Pediatrics December 28, 2020
See More Patient Information
- Best Practices for COVID-19–Positive or Exposed Mothers—Breastfeeding and Pumping Milk Sullivan SE, Thompson LA JAMA Pediatrics October 26, 2020
- What Is Herd Immunity? Desai AN, Majumder MS JAMA October 19, 2020
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  Risk of COVID-19 During Air Travel Pombal R, Hosegood I, Powell D JAMA October 1, 2020
- Current and COVID-19 Challenges With Childhood and Adolescent Sleep Stern M, Wagner MH, Thompson LA JAMA Pediatrics September 28, 2020
- Prone Positioning for Acute Respiratory Distress Syndrome (ARDS) Hadaya J, Benharash P JAMA August 21, 2020
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  Caring for Someone With COVID-19 Mortenson LY, Malani PN, Ernst RD JAMA August 13, 2020
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  What Is COVID-19? Wiersinga WJ, Prescott HC JAMA July 10, 2020
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  Convalescent Plasma and COVID-19 Malani AN, Sherbeck JP, Malani PN JAMA June 15, 2020
- What Is Anosmia? Huynh PP, Ishii LE, Ishii M JAMA June 18, 2020
- Extracorporeal Membrane Oxygenation Hadaya J, Benharash P JAMA May 28, 2020
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  Masks and Coronavirus Disease 2019 (COVID-19) Desai AN, Aronoff DM JAMA April 17, 2020
- Food Safety and COVID-19 Desai AN, Aronoff DM JAMA April 9, 2020
- Testing Individuals for Coronavirus Disease 2019 (COVID-19) Hadaya J, Schumm M, Livingston EH JAMA April 1, 2020
- Stopping the Spread of COVID-19 Desai AN, Patel P JAMA March 20, 2020
- What Does the Coronavirus Disease 2019 (COVID-19) Mean for Families? Thompson LA, Rasmussen SA JAMA Pediatrics March 13, 2020
- Medical Masks Desai AN, Mehrotra P JAMA March 4, 2020
- Coronavirus Disease 2019 and Influenza Livingston E, Bucher K, Rekito A JAMA February 26, 2020
- What Is a Pandemic? Grennan, D JAMA March 5, 2019

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