Updated March 2022 - Coronavirus (COVID-19) Resource Center | JAMA

With the global coronavirus pandemic entering its third year, transmission of the Omicron variant (B.1.1.529) and its subvariants (B.2, B.3) appears to be waning, with local governments loosening public health restrictions. A majority of the US population is now estimated to be immune to SARS-CoV-2 through vaccination or natural infection, but experience and data suggest future emergence of new variants is likely, with unpredictable implications for current prevention and treatment strategies.

Browse the JAMA Network COVID-19 collection below, including Q&A's with NIAID's Anthony Fauci and Patient Information pages.

Featured
Strategies to Promote Equity in COVID-19 Antiviral Treatment Fiscella K, Sanders M, Yaeger J JAMA Health Forum March 25, 2022
Estimated COVID-19 Cases and Hospitalizations Averted by Case Investigation and Contact Tracing in the US Rainisch G, Jeon S, Pappas D, et al. JAMA Network Open March 25, 2022
Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes Fell DB, Dhinsa T, Alton GD, et al. JAMA March 24, 2022
Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes Magnus MC, Örtqvist AK, Dahlqwist E, et al. JAMA March 24, 2022
COVID-19 Cases and Disease Severity in Pregnancy and Neonatal Positivity Associated With Delta (B.1.617.2) and Omicron (B.1.1.529) Variant Predominance Adhikari EH, MacDonald L, SoRelle JA, Morse J, Pruszynski J, Spong CY JAMA March 24, 2022
COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy Kharbanda EO, Vazquez-Benitez G JAMA March 24, 2022
Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19 Chow JH, Rahnavard A, Gomberg-Maitland M, et al. JAMA Network Open March 24, 2022
Changes in Buprenorphine Prescribing to Medicaid Beneficiaries During the First Year of the COVID-19 Pandemic Dowd WN, Mark TL JAMA Network Open March 24, 2022
Even Mild COVID-19 May Change the Brain Abbasi J JAMA March 23, 2022
Neuropsychiatric and Cognitive Outcomes in Patients 6 Months After COVID-19 Requiring Hospitalization Compared With Matched Control Patients Hospitalized for Non–COVID-19 Illness Nersesjan V, Fonsmark L, Christensen RHB, et al. JAMA Psychiatry March 23, 2022
Challenges of the COVID-19 Pandemic Among Individuals With Autism Spectrum Disorder Bitan DT, Krieger I, Weinstein O JAMA Psychiatry March 23, 2022
One Person Stead W JAMA March 22/29, 2022
COVID-19 Booster Shot Data Now Available From Nursing Homes Suran M JAMA March 22/29, 2022
Federal Government Buys Thousands of Bebtelovimab Doses Suran M JAMA March 22/29, 2022
Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial REMAP-CAP Writing Committee for the REMAP-CAP Investigators JAMA March 22, 2022
Thromboinflammation and Antithrombotics in COVID-19: Accumulating Evidence and Current Status Connors JM, Ridker PM JAMA March 22, 2022
SARS-CoV-2 Placentitis and Intraparenchymal Thrombohematomas Among COVID-19 Infections in Pregnancy Huynh A, Sehn JK, Goldfarb IT, et al. JAMA Network Open March 21, 2022
Forecasted and Observed Drug Overdose Deaths in the US During the COVID-19 Pandemic in 2020 Cartus AR, Li Y, Macmadu A, et al. JAMA Network Open March 21, 2022
Comparison of Trials Using Ivermectin for COVID-19 Between Regions With High and Low Prevalence of Strongyloidiasis: A Meta-analysis Bitterman A, Martins CP, Cices A, Nadendla MP JAMA Network Open March 21, 2022
Perinatal Complications in Individuals in California With or Without SARS-CoV-2 Infection During Pregnancy Ferrara A, Hedderson MM, Zhu Y, et al. JAMA Internal Medicine March 21, 2022

Coronavirus (COVID-19) Q&A

Conversations with Frontline Clinicians and Experts about the COVID-19 pandemic.

Coronavirus Video Q&A JAMA Network editors interview guests about the latest developments in the global coronavirus outbreak. Watch for updates on COVID-19 diagnosis and treatment.
Coronavirus Audio Q&A Conversations with frontline clinicians and experts on the frontiers of the global COVID-19 pandemic, hosted by JAMA Network editors.

Editors' Choice
Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial REMAP-CAP Writing Committee for the REMAP-CAP Investigators JAMA March 22, 2022
Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial Lim SCL, Hor CP, Tay KH, et al. JAMA Internal Medicine February 18, 2022
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Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial Perkins GD, Ji C, Connolly BA, et al. JAMA January 24, 2022
A National Strategy for the “New Normal” of Life With COVID Emanuel EJ, Osterholm M, Gounder CR JAMA January 6, 2022
Winter of Omicron—The Evolving COVID-19 Pandemic del Rio C, Omer SB, Malani PN JAMA December 22, 2021
One Year of COVID-19 Vaccines: A Shot of Hope, a Dose of Reality Cohn AC, Mahon BE, Walensky RP JAMA December 21, 2021
Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barré Syndrome, February-July 2021 Woo EJ, Mba-Jonas A, Dimova RB, Alimchandani M, Zinderman CE, Nair N JAMA October 7, 2021
Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial Spyropoulos AC, Goldin M, Giannis D, et al. JAMA Internal Medicine October 7, 2021
Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial Writing Committee for the REMAP-CAP Investigators JAMA October 4, 2021
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group JAMA July 6, 2021
Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military Montgomery J, Ryan M, Engler R, et al. JAMA Cardiology June 29, 2021
US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021 See I, Su JR, Lale A, et al. JAMA April 30, 2021
SARS-CoV-2–Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women Perl SH, Uzan-Yulzari A, Klainer H, et al. JAMA April 12, 2021
Helping the Public Understand Adverse Events Associated With COVID-19 Vaccinations: Lessons Learned From Functional Neurological Disorder Kim DD, Kung CS, Perez DL JAMA Neurology April 9, 2021
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Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial INSPIRATION Investigators JAMA March 18, 2021
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Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial López-Medina E, López P, Hurtado IC, et al. JAMA March 4, 2021
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SARS-CoV-2 Vaccines Creech CB, Walker SC, Samuels RJ JAMA February 26, 2021
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Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19 Feldstein LR, Tenforde MW, Friedman KG, et al. JAMA February 24, 2021
Effectiveness of Mask Wearing to Control Community Spread of SARS-CoV-2 Brooks JT, Butler JC JAMA February 10, 2021
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Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children Ouldali N, Toubiana J, Antona D, et al. JAMA February 1, 2021
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SARS-CoV-2 Transmission From People Without COVID-19 Symptoms Johansson MA, Quandelacy TM, Kada S, et al. JAMA Network Open January 7, 2021
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Genetic Variants of SARS-CoV-2—What Do They Mean? Lauring AS, Hodcroft EB JAMA January 6, 2021
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Therapy for Early COVID-19: A Critical Need Kim PS, Read SW, Fauci AS JAMA November 11, 2020
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COVID-19 and the Path to Immunity Stephens DS, McElrath MJ JAMA September 11, 2020
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Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group JAMA September 2, 2020
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Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) Wiersinga WJ, Rhodes A, Cheng AC, et al. JAMA July 10, 2020
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Is the Prone Position Helpful During Spontaneous Breathing in Patients With COVID-19? Telias I, Katira BH, Brochard L JAMA May 15, 2020
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Public Health Measures and the Reproduction Number of SARS-CoV-2 Inglesby TV JAMA May 1, 2020
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China 中文 (chinese) Wu Z, McGoogan JM JAMA February 24, 2020
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Characteristics of Hospitalized Patients With 2019-nCoV Pneumonia in Wuhan, China 中文 (chinese) Wang D, Hu B, Hu C, et al. JAMA February 7, 2020
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Coronavirus Infections—More Than Just the Common Cold Paules CI, Marston HD, Fauci AS JAMA January 23, 2020

Patient Information

Easy-to-understand information on COVID-19 to share with patients and their families.

COVID-19 and Pregnancy Walter K JAMA December 10, 2021
Variants of SARS-CoV-2 Lauring AS, Malani PN JAMA August 13, 2021
Olfactory Loss and Olfactory Training Patel ZM JAMA Otolaryngology July 15, 2021
Return to Play After COVID-19 Infection in Children Thompson LA, Kelly MN JAMA Pediatrics June 28, 2021
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Children and COVID-19 Vaccines Thompson LA, Rasmussen SA JAMA Pediatrics June 4, 2021
Monoclonal Antibodies for COVID-19 Lloyd EC, Gandhi TN, Petty LA JAMA February 5, 2021
Necessity of 2 Doses of the Pfizer and Moderna COVID-19 Vaccines Livingston EH JAMA February 3, 2021
One Year Later, How Does COVID-19 Affect Children? Thompson LA, Rasmussen SA JAMA Pediatrics December 28, 2020
Best Practices for COVID-19–Positive or Exposed Mothers—Breastfeeding and Pumping Milk Sullivan SE, Thompson LA JAMA Pediatrics October 26, 2020
What Is Herd Immunity? Desai AN, Majumder MS JAMA October 19, 2020
See More Patient Information
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  Risk of COVID-19 During Air Travel Pombal R, Hosegood I, Powell D JAMA October 1, 2020
- Current and COVID-19 Challenges With Childhood and Adolescent Sleep Stern M, Wagner MH, Thompson LA JAMA Pediatrics September 28, 2020
- Prone Positioning for Acute Respiratory Distress Syndrome (ARDS) Hadaya J, Benharash P JAMA August 21, 2020
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  Caring for Someone With COVID-19 Mortenson LY, Malani PN, Ernst RD JAMA August 13, 2020
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  What Is COVID-19? Wiersinga WJ, Prescott HC JAMA July 10, 2020
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  Convalescent Plasma and COVID-19 Malani AN, Sherbeck JP, Malani PN JAMA June 15, 2020
- What Is Anosmia? Huynh PP, Ishii LE, Ishii M JAMA June 18, 2020
- Extracorporeal Membrane Oxygenation Hadaya J, Benharash P JAMA May 28, 2020
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  Masks and Coronavirus Disease 2019 (COVID-19) Desai AN, Aronoff DM JAMA April 17, 2020
- Food Safety and COVID-19 Desai AN, Aronoff DM JAMA April 9, 2020
- Testing Individuals for Coronavirus Disease 2019 (COVID-19) Hadaya J, Schumm M, Livingston EH JAMA April 1, 2020
- Stopping the Spread of COVID-19 Desai AN, Patel P JAMA March 20, 2020
- What Does the Coronavirus Disease 2019 (COVID-19) Mean for Families? Thompson LA, Rasmussen SA JAMA Pediatrics March 13, 2020
- Medical Masks Desai AN, Mehrotra P JAMA March 4, 2020
- Coronavirus Disease 2019 and Influenza Livingston E, Bucher K, Rekito A JAMA February 26, 2020
- What Is a Pandemic? Grennan, D JAMA March 5, 2019

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