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Invited Commentary
October 2016

Random Plasma Glucose Levels and Cardiovascular Risk

Author Affiliations
  • 1Global Health Research Center, Duke Kunshan University, Kunshan, China
  • 2School of Public Health, Wuhan University, Wuhan, China
  • 3National Heart Centre and Duke-National University of Singapore, Singapore
JAMA Cardiol. 2016;1(7):823-824. doi:10.1001/jamacardio.2016.1802

The first global report on diabetes published by the World Health Organization in April 20161 spotlighted the increasing public health problem of diabetes. The global diabetic population quadrupled from 108 million in 1980 to 422 million in 2014. China has the largest population of people living with diabetes, estimated at nearly 100 million as of 2013 and projected to grow to more than 142 million by 2035.2 Cardiovascular disease is a well-known serious complication of diabetes.3 Data from 4 European cohorts showed that isolated increases in the fasting or 2-hour postload plasma glucose level, even at levels below traditional cutoffs for diabetes, had a significant effect on cardiovascular risk.4,5 However, important gaps in knowledge remain regarding the association of random plasma glucose (RPG) levels with cardiovascular risk and the validity of these observations in non-European cohorts.

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