To the Editor In the August issue of JAMA Cardiology, Khambaty et al1 reported that major depressive disorder may be independently associated with incident cardiovascular disease (CVD) in those with human immunodeficiency virus (HIV) infection. This study adds to the existing literature on an association between depression and CVD in other conditions. However, caution must be exercised before assuming causality or even when considering the directionality of such a relationship.
Ziegelstein RC. Association of Depression and Cardiovascular Disease. JAMA Cardiol. 2017;2(6):702. doi:10.1001/jamacardio.2016.5984
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