Cardiovascular Risk Prediction in Patients With Human Immunodeficiency Virus

To the Editor We read with interest the article by Feinstein et al¹ in the February issue of JAMA Cardiology. Despite the well-known increased risk of cardiovascular disease in patients with human immunodeficiency virus (HIV), there do not seem to be good prediction models to accurately estimate risk. Feinstein et al¹ noted that the accuracy of the prediction models may be particularly low in women and Hispanic individuals and that the equations may work best in patients at moderate to high risk. Furthermore, there was no evidence that adding HIV-specific risk factors to algorithms based on traditional risk factors, such as the Pooled Equations, increased the performance of these models.