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Comment & Response
September 2017

The Controversial Epidemiology of Left Ventricular Dysfunction in Patients With Myotonic Dystrophy Type 1

Author Affiliations
  • 1Chair of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy
JAMA Cardiol. 2017;2(9):1044. doi:10.1001/jamacardio.2017.0927

To the Editor In a recent issue of JAMA Cardiology, we read with great interest the report of Tanawuttiwat et al1 entitled “Left Ventricular Dysfunction and Conduction Disturbances in Patients With Myotonic Muscular Dystrophy Type I and II.” In their well-written research letter, the authors described the baseline prevalence and longitudinal incidence of conduction abnormalities and left ventricular dysfunction in a large single-center cohort of patients with myotonic muscular dystrophy type 1 and type 2 (DM1 and DM2). The authors defined left ventricular dysfunction (LVD) as an ejection fraction less than 55%, which differs from previous studies that used cutoffs of 50% or less. They reported a prevalence of left ventricular dysfunction at baseline in patients with DM1 of 11.8%, with an incidence of 2% during the follow-up period (mean, 5.76 years).