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Comment & Response
September 2017

Ischemic Postconditioning During Primary Percutaneous Coronary Intervention: Is Smoker’s Paradox in Play?—Reply

Author Affiliations
  • 1Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • 2Department of Cardiology, Zealand University Hospital, Roskilde, Denmark
JAMA Cardiol. 2017;2(9):1050. doi:10.1001/jamacardio.2017.2481

In Reply We thank Olafiranye for his interest in our work evaluating the effect of ischemic postconditioning in patients with ST-segment elevation myocardial infarction who are admitted for primary percutaneous coronary intervention.1 Smoking is a well-established risk factor for the development of cardiovascular disease.2 In this context, smoker’s paradox is a true paradox. The concept, first described in 1977 by Kitchin et al,3 was based on observations that current or previous smokers had a lower mortality after an acute myocardial infarction than nonsmokers. Similar data were subsequently recorded by others.4

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