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Comment & Response
December 2017

Safety vs Efficacy of Lowering Blood Pressure—Reply

Author Affiliations
  • 1Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
  • 2Deputy Editor, JAMA Cardiology
  • 3Editor, JAMA Cardiology
JAMA Cardiol. 2017;2(12):1400. doi:10.1001/jamacardio.2017.3540

In Reply Given the importance of hypertension, we anticipated a high degree of interest in the network meta-analysis published by Bundy et al1 and our accompanying Editorial, “New Blood Pressure–Lowering Targets: Finding Clarity.”2 As new blood pressure–lowering targets are contemplated and eventually incorporated into clinical practice guidelines, major public health implications, including safety, emerge and are accompanied by new opportunities to significantly lower the global burden of cardiovascular disease. The letters by Bavishi et al and Gąsowski et al both echo the overall assessment that lower blood pressure targets will become a new standard of care and raise important concerns regarding safety. We concur.