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Comment & Response
January 2018

Coronary Computed Tomography–Based Fractional Flow Reserve: A Rapidly Developing Field

Author Affiliations
  • 1Heart and Vascular Center, Medical University of South Carolina, Charleston
  • 2First Department of Medicine-Cardiology, University Medical Centre Mannheim, Mannheim, Germany
  • 3Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany
JAMA Cardiol. 2018;3(1):87. doi:10.1001/jamacardio.2017.4249

To the Editor Coronary computed tomography angiography (cCTA)–based fractional flow reserve (FFR-CT) is an evolving technology of disruptive potential to noninvasively determine the hemodynamic significance of a coronary artery stenosis. The systematic review by Cook et al1 provides an excellent overview on the status of this innovative method. In their Methods section, the authors mention the FFR-CT algorithm approved by the US Food and Drug Administration in late 2014.1 However, technology and evidence in this field are rapidly evolving, which adds new facets to their discussion.

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