Every 42 seconds, approximately 1 American individual will have an acute myocardial infarction (AMI).1 Acute myocardial infarction is a frequent cause of hospital admission in the United States and is associated with significant mortality and morbidity. Survivors of AMI are at increased risk for recurrent cardiovascular events, and its cost burden on the health care system remains substantial. Gaps, disparities, and variability in AMI care exist. Performance measure sets can facilitate the translation of scientific evidence and guidelines into clinical practice.