To the Editor A December 2017 JAMA Cardiology article by Gay et al1 sought to replicate findings of the SMART-AF trial2 that assessed the safety and effectiveness of an irrigated, contact force–sensing catheter in patients with drug-refractory paroxysmal atrial fibrillation.2 While both analyses arrived at the same general conclusions, some results differed. As authors and researchers of the original SMART-AF trial, we wish to elucidate our methods and describe potential reasons for these differences. The reproduction analysis represents the forefront of a move to data sharing, and the complexities we discuss are widely applicable to other such efforts.
Natale A, Stagg R, Zhang B. Different Population and End Point Definitions in Reproduction Analysis Based on Shared Data. JAMA Cardiol. 2018;3(9):893–894. doi:https://doi.org/10.1001/jamacardio.2018.1788
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