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Comment & Response
September 2018

Different Population and End Point Definitions in Reproduction Analysis Based on Shared Data

Author Affiliations
  • 1Texas Cardiac Arrhythmia Institute at St David’s Medical Center, Austin
  • 2Biosense Webster Inc, Irvine, California
JAMA Cardiol. 2018;3(9):893-894. doi:10.1001/jamacardio.2018.1788

To the Editor A December 2017 JAMA Cardiology article by Gay et al1 sought to replicate findings of the SMART-AF trial2 that assessed the safety and effectiveness of an irrigated, contact force–sensing catheter in patients with drug-refractory paroxysmal atrial fibrillation.2 While both analyses arrived at the same general conclusions, some results differed. As authors and researchers of the original SMART-AF trial, we wish to elucidate our methods and describe potential reasons for these differences. The reproduction analysis represents the forefront of a move to data sharing, and the complexities we discuss are widely applicable to other such efforts.

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